Protein Alignment DNM2 and dnm2a

DIOPT Version :10

• Sequence 1: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Sequence 2: XP_068073278.1
• Gene: dnm2a / 559334
• ZFINID: ZDB-GENE-050913-84
• Length: 903
• Species: Danio rerio
• Alignment Length: 916
• Identity: 749/916 - (81%)
• Similarity: 812/916 - (88%)
• Gaps: 59/916 - (6%)

Human     1 MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVT 65
            ||||||||||||:||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish     1 MGNRGMEELIPLINKLQDAFSSIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVT 65

Human    66 RRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVL 130
            ||||||||:.:|.|:|||||||.:||.|||||||||||||||:||:||||||:|||||||||:||
Zfish    66 RRPLILQLVNNKAEYAEFLHCKGRKFVDFDEVRQEIEAETDRITGSNKGISPIPINLRVYSPNVL 130

Human   131 NLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDP 195
            |||||||||:|||.|||||||||:||:|||:|||:|||.|||||||||||||||||||:||||||
Zfish   131 NLTLIDLPGMTKVAVGDQPPDIEHQIRDMIMQFITRESCLILAVTPANMDLANSDALKVAKEVDP 195

Human   196 QGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFL 260
            |||||||||||||||||||||||:|||||||||||||||||||||||:|:|||||||||||||||
Zfish   196 QGLRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGRKDIRAALAAERKFFL 260

Human   261 SHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRK 325
            |||:|||||:|||||||||.||||||||||::||.||||||||||||||||||||||||||||||
Zfish   261 SHPSYRHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEYKNFRPDDPTRK 325

Human   326 TKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISY 390
            |||||||||||||||||.||||||||||.||||||||||||||||||||||:.||||:||||||:
Zfish   326 TKALLQMVQQFGVDFEKCIEGSGDQVDTAELSGGARINRIFHERFPFELVKIVFDEKELRREISH 390

Human   391 AIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREE 455
            ||||:|||||||||||||||||||||::|||||||||:||||||||||.||||:|||||||||||
Zfish   391 AIKNVHGVRTGLFTPDLAFEAIVKKQIIKLKEPCLKCIDLVIQELINTFRQCTNKLSSYPRLREE 455

Human   456 TERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAN------------------AQQR 502
            ||||||||:|||||:||||:|||||.|.|||||||||||||||                  ||||
Zfish   456 TERIVTTYVREREGKTKDQVLLLIDTELSYINTNHEDFIGFANLDLRRLDDGTIPGYSNNSAQQR 520

Human   503 STQLNKKRAIPNQ------GEI-LVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEE--- 557
            :. :|||||||||      ||. .|||:||||: |||:||||||||||||||||||||||||
Zfish   521 NI-VNKKRAIPNQLGGLREGEAEKVIRKGWLTL-NISIMKGGSKEYWFVLTAESLSWYKDEEINK 583

Human   558 ---------------EKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELAC 607
                           ||||||||||||||:|||||||||.||:||||||||||||||||||||||
Zfish   584 NVHLTCFFNICKHITEKEKKYMLPLDNLKLRDVEKGFMSTKHIFAIFNTEQRNVYKDLRQIELAC 648

Human   608 DSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR 672
            |||||:||||||||||||||||||.|:|:.|..::|||||||||||||||||||||:.|:||:||
Zfish   649 DSQEDMDSWKASFLRAGVYPEKDQVESEEAAPADSFSMDPQLERQVETIRNLVDSYIGIVNKTIR 713

Human   673 DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIG 737
            |||||||||||||:.|.|||.|||||||||.||:||||||||||||||:|||||||:||||:|||
Zfish   714 DLMPKTIMHLMINSAKDFIHSELLAYLYSSGDQNSLMEESADQAQRRDEMLRMYHAIKEALSIIG 778

Human   738 DISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAA 802
            ||||||:||||||||:|:|:...   ||||||||.:|..||.|||||||||||||    |:....
Zfish   779 DISTSTISTPVPPPVNDSWIPET---SPTPQRRPPTSAPPPNRPPAVRGPTPGPP----PLNPTP 836

Human   803 SFSAPPIPSRPG-PQSVFANS--DLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPA 864
            ||:||||||||| |.:.|.||  |.|.|||||||||.|    |||||||||||.||:||||||||
Zfish   837 SFAAPPIPSRPGQPMNAFGNSSQDPFSAPPQIPSRPAR----IPPGVPSRRPPGAPNRPTIIRPA 897

Human   865 EPSLLD 870
            ||||||
Zfish   898 EPSLLD 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	214/238 (90%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	260/304 (86%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	100/126 (79%)
		GED	649..739	CDD:460495	76/89 (85%)
		PHA03247	<737..868	CDD:223021	92/133 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870		90/131 (69%)
dnm2a	XP_068073278.1	DYNc	6..245	CDD:197491	214/238 (90%)
		Dynamin_M	215..498	CDD:460033	256/282 (91%)
		PH_dynamin	544..670	CDD:269958	100/126 (79%)
		GED	690..780	CDD:460495	76/89 (85%)
		PHA03247	<782..900	CDD:223021	87/128 (68%)