Protein Alignment DNM2 and dnm2

DIOPT Version :10

• Sequence 1: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Sequence 2: XP_031753735.1
• Gene: dnm2 / 496487
• XenbaseID: XB-GENE-959257
• Length: 881
• Species: Xenopus tropicalis
• Alignment Length: 883
• Identity: 799/883 - (90%)
• Similarity: 840/883 - (95%)
• Gaps: 15/883 - (1%)

Human     1 MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVT 65
            |||||||||||||||||||||||||:|:|||||||||||||||||||||||||||||||||||||
 Frog     1 MGNRGMEELIPLVNKLQDAFSSIGQACNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVT 65

Human    66 RRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVL 130
            ||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||:||
 Frog    66 RRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPNVL 130

Human   131 NLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDP 195
            |||||||||||||||||||.||||||||||||||||:|.|||||||.|.|||||||||:||||||
 Frog   131 NLTLIDLPGITKVPVGDQPHDIEYQIKDMILQFISRDSCLILAVTPGNTDLANSDALKMAKEVDP 195

Human   196 QGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFL 260
            |||||||||||||||||||||:|:|||||||||||||||||||||||:|||||:|||.|||||||
 Frog   196 QGLRTIGVITKLDLMDEGTDAKDILENKLLPLRRGYIGVVNRSQKDIDGKKDIKAALGAERKFFL 260

Human   261 SHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRK 325
            |||.|||:|:|||||||||||||||||||||:|||||:|||||||||||||||||||||||||||
 Frog   261 SHPGYRHIAERMGTPHLQKTLNQQLTNHIRETLPALRNKLQSQLLSLEKEVEEYKNFRPDDPTRK 325

Human   326 TKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISY 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   326 TKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISY 390

Human   391 AIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREE 455
            ||||||||||||||||:||||||||||||||||||||||:|||||||||||||:||.|||:||||
 Frog   391 AIKNIHGVRTGLFTPDMAFEAIVKKQVVKLKEPCLKCVDMVIQELINTVRQCTAKLLSYPKLREE 455

Human   456 TERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFAN----------AQQRSTQLNKKR 510
            ||||||||||||||:||||||||||||.|||||||||||||||          |||||:||||||
 Frog   456 TERIVTTYIREREGKTKDQILLLIDIELSYINTNHEDFIGFANAYYTEQIIPGAQQRSSQLNKKR 520

Human   511 AIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDV 575
            |:||||||||||||||||||||:||||||||||:||||||||||||||||||||||||||||||:
 Frog   521 AVPNQGEILVIRRGWLTINNISIMKGGSKEYWFILTAESLSWYKDEEEKEKKYMLPLDNLKIRDI 585

Human   576 EKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQE 640
            ||||||.||:||||||||||||||||||||||||||||||||||||||||||||||.|.|: .||
 Frog   586 EKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQREEEE-TQE 649

Human   641 NTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQ 705
            |||||||||||||||||||||||:.|:|||||||||||||||||||:|.|||.||||||||||||
 Frog   650 NTFSMDPQLERQVETIRNLVDSYICIVNKSIRDLMPKTIMHLMINNSKDFIHSELLAYLYSSADQ 714

Human   706 SSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS-HSPTPQR 769
            :|||||||||||||:|||||||||||||.|||||||||.:|||||||||||||:::| ||||.||
 Frog   715 NSLMEESADQAQRREDMLRMYHALKEALKIIGDISTSTATTPVPPPVDDTWLQNSNSGHSPTVQR 779

Human   770 RPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVF--ANSDLFPAPPQIP 832
            ||||::.||.||||||||||||||||||.|.:| |.|||||||||||..|  ||:|.|.||||||
 Frog   780 RPVSTVLPPSRPPAVRGPTPGPPLIPVPAGGSA-FIAPPIPSRPGPQGPFAAANNDPFSAPPQIP 843

Human   833 SRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD 870
            |||.|||||:|||||||||||||:||||||||||||||
 Frog   844 SRPARIPPGVPPGVPSRRPPAAPTRPTIIRPAEPSLLD 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	225/238 (95%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	269/296 (91%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	103/108 (95%)
		GED	649..739	CDD:460495	80/89 (90%)
		PHA03247	<737..868	CDD:223021	107/133 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870		105/131 (80%)
dnm2	XP_031753735.1	DYNc	6..245	CDD:197491	225/238 (95%)
		Dynamin_M	215..499	CDD:460033	266/283 (94%)
		PH_dynamin	530..639	CDD:269958	103/108 (95%)
		GED	658..748	CDD:460495	80/89 (90%)
		PHA03247	<748..877	CDD:223021	103/129 (80%)