Protein Alignment DNM2 and shi

DIOPT Version :10

• Sequence 1: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_001259588.1
• Gene: shi / 45928
• FlyBaseID: FBgn0003392
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 881
• Identity: 578/881 - (65%)
• Similarity: 684/881 - (77%)
• Gaps: 62/881 - (7%)

Human     6 MEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70
            |:.||.:||||||||:|:|....|||||||||||||||||||||||||:||||||||||||||||
  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65

Human    71 LQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLI 135
            ||||...||:.||||.|.|||:.|||:|:|||.|||||||:|||||.:|||||||||||||||||
  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130

Human   136 DLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRT 200
            ||||:|||.:||||.|||.|||.||.|||.:|:.|||||||||.||||||||||||||||||:||
  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195

Human   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAY 265
            ||||||||||||||||||:|||||||||||||||||||||||||:|||..|||||||||||||:|
  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260

Human   266 RHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALL 330
            ||||||:|||:||:.||||||||||::||.||.|||.|:|:|||||||:|:|:|.|.:.||||:|
  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325

Human   331 QMVQQFGVDFEKRIEGSGDQ-VDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKN 394
            ||:||...|||:.|||||.. |:|.||||||:||||||||..||:|||..|||:||||||:||:|
  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390

Human   395 IHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERI 459
            |||:|.||||||:|||||||:|:..||||.:||||||:|||...||.||:|:|.|||||||||||
  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455

Human   460 VTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNK--KRAIPNQGEILVIR 522
            :||::|:||...|:|||||||.|.:|:||||||||||||||.:|...||  .|.:.||    |||
  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516

Human   523 RGWLTINNISLMK-------------------GGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLD 568
            :|.:.|.|:.:||                   |||:.||||||:||:||||||:|||||:|||||
  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581

Human   569 NLKIRDVEKGF--MSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQ 631
            .||:||:|:||  ||.:..||:|:.:.||||||.:|:||:|::.|||:|||||||||||||||.:
  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQE 646

Human   632 A-ENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHEL 695
            . ||.|.:.....|.||||||||||||||||||:.|:.|:.||::||.||.|:|||.|.||:.||
  Fly   647 TQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGEL 711

Human   696 LAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSA 760
            ||:||:|.||:.:|||||:.|.||::|||||.|.|:||.||||:|.:|||:|:||||.:.||.|.
  Fly   712 LAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSG 776

Human   761 SSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSA--PPIPSRPGPQSVFANSD 823
            ..:   |:..|.|       |..||| .||||       |.:|...  ||:|...|.
  Fly   777 LDN---PRLSPPS-------PGGVRG-KPGPP-------AQSSLGGRNPPLPPSTGR-------- 815

Human   824 LFPAPPQIPSRPVRIPPGIPPGVP--SRRPPAAPSR 857
              || |.||:||....|.:|.|.|  |..||..|||
  Fly   816 --PA-PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSR 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	198/238 (83%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	214/287 (75%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	73/129 (57%)
		GED	649..739	CDD:460495	59/89 (66%)
		PHA03247	<737..868	CDD:223021	48/125 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870		45/121 (37%)
shi	NP_001259588.1	DYNc	1..240	CDD:197491	198/238 (83%)
		Dynamin_M	210..498	CDD:460033	214/287 (75%)
		PH_dynamin	512..644	CDD:269958	75/135 (56%)
		GED	664..755	CDD:128597	60/90 (67%)
		FAP	725..>855	CDD:429334	67/153 (44%)