DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNM2 and vps1

DIOPT Version :10

Sequence 1:NP_001005360.1 Gene:DNM2 / 1785 HGNCID:2974 Length:870 Species:Homo sapiens
Sequence 2:NP_001342849.1 Gene:vps1 / 2542724 PomBaseID:SPAC767.01C Length:678 Species:Schizosaccharomyces pombe


Alignment Length:764 Identity:294/764 - (38%)
Similarity:417/764 - (54%) Gaps:123/764 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     9 LIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQL 73
            ||.:||:||:|||::|....:|||||.||..||:||||||||.|||||||||:||||||||:|||
pombe     5 LIKVVNQLQEAFSTVGVQNLIDLPQITVVRSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQL 69

Human    74 I---------------------FSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISP 117
            |                     .:.:|..||||...:||.:|:::|:||..||:..||.|.|||.
pombe    70 INRPSASGKNEETTTDSDGKDQNNSSEWGEFLHLPGQKFFEFEKIREEIVRETEEKTGKNVGISS 134

Human   118 VPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLA 182
            |||.||:||||||.|||:||||:|||||||||.|||.||::|:|::||:.:::||||..||.|||
pombe   135 VPIYLRIYSPHVLTLTLVDLPGLTKVPVGDQPRDIEKQIREMVLKYISKNNAIILAVNAANTDLA 199

Human   183 NSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKD 247
            |||.||||:||||:|||||||:||:||||:|||..|:|..:::|||.||:.|:||.||||||||.
pombe   200 NSDGLKLAREVDPEGLRTIGVLTKVDLMDKGTDVVDILAGRVIPLRLGYVPVINRGQKDIEGKKS 264

Human   248 IRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVE 312
            ||.||.|||.||.:||:|...|...|||.|.:.||..|.:|||.:||.::.::.:.|...:.|:.
pombe   265 IRIALEAERNFFETHPSYGSKAQYCGTPFLARKLNMILMHHIRNTLPEIKVRINAALAKYQAELH 329

Human   313 EYKNFRPDDPTRKTKAL-LQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERF------ 370
            ..    .|.|.....:: |.::..|..::...::|..:::...||||||||..:|||.|      
pombe   330 SL----GDTPVGDNSSIVLNLITDFCNEYRTVVDGRSEELSATELSGGARIAFVFHEIFSNGIQA 390

Human   371 --PFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQ 433
              ||:.||    :.|: |.|.|   |..|....||....|||.|||:|:.:|::|.||||.|:..
pombe   391 IDPFDEVK----DSDI-RTILY---NSSGPSPSLFMGTAAFEVIVKQQIKRLEDPSLKCVSLIYD 447

Human   434 ELINTVRQCTSK--LSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGF 496
            ||:..:.|...:  ...||.|::|..::|..:.|:....|...::.::.:|.|||||.|.||:. 
pombe   448 ELVRILNQLLQRPIFKRYPLLKDEFYKVVIGFFRKCMQPTNTLVMDMVAMEGSYINTVHPDFLS- 511

Human   497 ANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEK 561
            .:......|....:.||                                             .:.
pombe   512 GHQAMAIVQSQNSKPIP---------------------------------------------VDP 531

Human   562 KYMLPLDNLKIRDVEKGFMSNKHVF-AIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGV 625
            |....|.|..:..||....|.::.| :.|.::.:   |.|..:|.           ....|||..
pombe   532 KTGKALTNNPVPPVETSSSSGQNFFGSFFGSKNK---KRLAAMEP-----------PPPVLRAST 582

Human   626 YPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAF 690
                              ::..:.:...|.|:.|:.||..|:.:::.|::||:|...||..:|..
pombe   583 ------------------TLSDREKTDTEVIKLLIMSYFNIVKRTLADMVPKSISLKMIKYSKEH 629

Human   691 IHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDI 739
            |.||||..||.|.....|::||....|||.:..:|..:|.:|..|:.::
pombe   630 IQHELLEQLYKSQAFDKLLQESEVTVQRRKECEQMVESLLQASEIVSNV 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNM2NP_001005360.1 DYNc 6..245 CDD:197491 154/256 (60%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 38..45 3/6 (50%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 64..66 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 136..139 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 205..208 2/2 (100%)
Dynamin_M 215..502 CDD:460033 108/297 (36%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 235..238 1/2 (50%)
PH_dynamin 520..629 CDD:269958 14/109 (13%)
GED 649..739 CDD:460495 31/89 (35%)
PHA03247 <737..868 CDD:223021 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..870
vps1NP_001342849.1 DLP_1 25..311 CDD:206738 170/285 (60%)
Dynamin_M 232..517 CDD:460033 108/297 (36%)
GED 588..678 CDD:460495 31/89 (35%)
Blue background indicates that the domain is not in the aligned region.

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