DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DNM2 and dnm1

DIOPT Version :10

Sequence 1:NP_001005360.1 Gene:DNM2 / 1785 HGNCID:2974 Length:870 Species:Homo sapiens
Sequence 2:NP_596014.1 Gene:dnm1 / 2540159 PomBaseID:SPBC12C2.08 Length:781 Species:Schizosaccharomyces pombe


Alignment Length:815 Identity:305/815 - (37%)
Similarity:440/815 - (53%) Gaps:116/815 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     6 MEELIPLVNKLQD-AFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPL 69
            ||:||||||:||| .:::|| |..||||.|.|||.||.||||||||.||:||||||:||||||||
pombe     1 MEQLIPLVNQLQDLVYNTIG-SDFLDLPSIVVVGSQSCGKSSVLENIVGKDFLPRGTGIVTRRPL 64

Human    70 ILQLIFSK---------------------------------------TEHAEFLHCKSKKFTDFD 95
            |||||..|                                       .::|||||....||||.:
pombe    65 ILQLINLKRKTKNNHDEESTSDNNSEETSAAGETGSLEGIEEDSDEIEDYAEFLHIPDTKFTDMN 129

Human    96 EVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMI 160
            :||.|||.||.||.|.||||:.:||||::||..|||||||||||:||:||||||.|||.|.:.:|
pombe   130 KVRAEIENETLRVAGANKGINKLPINLKIYSTRVLNLTLIDLPGLTKIPVGDQPTDIEAQTRSLI 194

Human   161 LQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLL 225
            :::|||.:|:||||:|||.|:.||:.||||:.|||:|.|||||:|||||||:||:|.|:|..::.
pombe   195 MEYISRPNSIILAVSPANFDIVNSEGLKLARSVDPKGKRTIGVLTKLDLMDQGTNAMDILSGRVY 259

Human   226 PLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIR 290
            ||:.|::..|||||.||...|.:|.||.:||.||..|||||.:.||.|||:|.|||:..|.:|||
pombe   260 PLKLGFVATVNRSQSDIVSHKSMRDALQSERSFFEHHPAYRTIKDRCGTPYLAKTLSNLLVSHIR 324

Human   291 ESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLE 355
            |.||.::::|.:.:...::::..|.:|:..|.:::...|||.:.:|...|...|:|:...:.|.|
pombe   325 ERLPDIKARLSTLISQTQQQLNNYGDFKLSDQSQRGIILLQAMNRFANTFIASIDGNSSNIPTKE 389

Human   356 LSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL 420
            ||||||:..||:..|...|..::..:.....:|..||.|..|.|..||..::||:.:||.|:..|
pombe   390 LSGGARLYSIFNNVFTTALNSIDPLQNLSTVDIRTAILNSTGSRATLFLSEMAFDILVKPQLNLL 454

Human   421 KEPCLKCVDLVIQELINTVRQC-TSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQS 484
            ..||.:||:||.:||:...... .|.:|.:|:|:......|:..:||....|...:..||.|:.:
pombe   455 AAPCHQCVELVYEELMKICHYSGDSDISHFPKLQTALVETVSDLLRENLTPTYSFVESLIAIQSA 519

Human   485 YINTNHEDFIGFANA--------QQRSTQLNKKRAIPNQGEILVIRRGWLTINNI-------SLM 534
            ||||||.||:|...|        :|....|:::...|....:..::...:.:.:.       |:.
pombe   520 YINTNHPDFLGVQGAMAVVLSRKEQNRLMLSQENDEPISSALDTVKPDGIELYSSDPDTSVKSIT 584

Human   535 KGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN--------KHVFAIFNT 591
            ...:.|   :.|.:|     |:..|    |.|||.|..:.....|.:.        .:||...|.
pombe   585 NKATNE---ITTLKS-----DDSAK----MQPLDVLASKRYNNAFSTETAERKTFLSYVFGANNA 637

Human   592 EQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQEN--------------T 642
            .::.:..|                      ::..||..|.....|...:|              |
pombe   638 TRKAMSID----------------------KSSSYPLNDSLSGGDTNHKNNHPLKMTDLSNEVET 680

Human   643 FSMDPQLER---QVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSAD 704
            .:::...||   :|:.|:.|:.||..:..|.|.|.:||.||||::|.:|..|.:.|::.||....
pombe   681 MALEDMSEREEVEVDLIKELITSYFNLTRKIIIDQVPKVIMHLLVNASKDAIQNRLVSKLYREDF 745

Human   705 QSSLMEESADQAQRRDDMLRMYHALKEALNIIGDI 739
            ..:|:.|..:....|:...|:.....:|..||..:
pombe   746 FDTLLIEDENVKSEREKCERLLSVYNQANKIISTV 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNM2NP_001005360.1 DYNc 6..245 CDD:197491 156/278 (56%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 38..45 4/6 (67%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 64..66 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 136..139 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 205..208 2/2 (100%)
Dynamin_M 215..502 CDD:460033 108/295 (37%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 235..238 2/2 (100%)
PH_dynamin 520..629 CDD:269958 18/123 (15%)
GED 649..739 CDD:460495 29/92 (32%)
PHA03247 <737..868 CDD:223021 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..870
dnm1NP_596014.1 DLP_1 24..328 CDD:206738 169/303 (56%)
Dynamin_M 249..536 CDD:460033 108/286 (38%)
GED 690..780 CDD:460495 27/89 (30%)
Blue background indicates that the domain is not in the aligned region.

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