Protein Alignment DNM2 and dyn-1

DIOPT Version :10

• Sequence 1: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_001024332.1
• Gene: dyn-1 / 181644
• WormBaseID: WBGene00001130
• Length: 838
• Species: Caenorhabditis elegans
• Alignment Length: 881
• Identity: 544/881 - (61%)
• Similarity: 670/881 - (76%)
• Gaps: 65/881 - (7%)

Human     3 NRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRR 67
            |:||:.|||::|::|||||.:|.|...:|||||||||||||||||||||||:|||||||||||||
 Worm     5 NQGMQALIPVINRVQDAFSQLGTSVSFELPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRR 69

Human    68 PLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
            |||||||..:.|:|||||.|..:|.|||.||:|||.|||||||.||||||.||||||:||:||||
 Worm    70 PLILQLIQDRNEYAEFLHKKGHRFVDFDAVRKEIEDETDRVTGQNKGISPHPINLRVFSPNVLNL 134

Human   133 TLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQG 197
            |||||||:|||||||||.|||.||:||||.||:||:.|||||||||.|||.||||||||||||||
 Worm   135 TLIDLPGLTKVPVGDQPADIEQQIRDMILTFINRETCLILAVTPANSDLATSDALKLAKEVDPQG 199

Human   198 LRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSH 262
            ||||||:|||||||||||||::|||||..|||||:|||||.||||.|:|||||||.||||||:||
 Worm   200 LRTIGVLTKLDLMDEGTDAREILENKLFTLRRGYVGVVNRGQKDIVGRKDIRAALDAERKFFISH 264

Human   263 PAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTK 327
            |:|||||||:||.:||.|||||||||||::||.||..||.::.::||:|.||||::|:||.||||
 Worm   265 PSYRHMADRLGTSYLQHTLNQQLTNHIRDTLPTLRDSLQKKMFAMEKDVAEYKNYQPNDPGRKTK 329

Human   328 ALLQMVQQFGVDFEKRIEGSGDQ-VDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYA 391
            ||||||.||..|.|:.||||..: |.|.||||||||||:||||||||:||||.|||::|:||.||
 Worm   330 ALLQMVTQFNADIERSIEGSSAKLVSTNELSGGARINRLFHERFPFEIVKMEIDEKEMRKEIQYA 394

Human   392 IKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREET 456
            |:||||:|.||||||:|||||.|||:.:||||.|||||||:.||.|.:|||...::.|||||:|.
 Worm   395 IRNIHGIRVGLFTPDMAFEAIAKKQITRLKEPSLKCVDLVVNELANVIRQCADTMARYPRLRDEL 459

Human   457 ERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQ-LNKKRAIPNQGEILV 520
            ||||.:::||||...|.||.|::|.|.:|:||||||||||:||:.:::| .:.|:.:.||    |
 Worm   460 ERIVVSHMREREQIAKQQIGLIVDYELAYMNTNHEDFIGFSNAEAKASQGQSAKKNLGNQ----V 520

Human   521 IRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHV 585
            ||:|||:::|:|.:: |||:.||||.::|||||||:||||||||||||.:|::|:|.||||..|.
 Worm   521 IRKGWLSLSNVSFVR-GSKDNWFVLMSDSLSWYKDDEEKEKKYMLPLDGVKLKDIEGGFMSRNHK 584

Human   586 FAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQE-NTFSMDPQL 649
            ||:|..:.:|:|||.:|:||.|.:.:::|:||||||||||||||.:|:.::..|| ...|:||||
 Worm   585 FALFYPDGKNIYKDYKQLELGCTNLDEIDAWKASFLRAGVYPEKQKAQEDESQQEMEDTSIDPQL 649

Human   650 ERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAD 714
            ||||||||||||||:.||.|:|:||:||.:|||::|.|..|:..||||:||...|..:|||||..
 Worm   650 ERQVETIRNLVDSYMRIITKTIKDLVPKAVMHLIVNQTGEFMKDELLAHLYQCGDTDALMEESQI 714

Human   715 QAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG 779
            :||:|::|||||||.||||.||.:::.||:... |||:            |....||    ||.|
 Worm   715 EAQKREEMLRMYHACKEALRIISEVNMSTLGDQ-PPPL------------PMSDYRP----HPSG 762

Human   780 RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP 844
            ..|..| |.|.||      |...:    |:|.|.||          .|||....||   |||.|.
 Worm   763 PSPVPR-PAPAPP------GGRQA----PMPPRGGP----------GAPPPPGMRP---PPGAPG 803

Human   845 G--------VPSRRP------PAAPSRPTIIRPAEP 866
            |        :|:|.|      |..|:||.:  |..|
 Worm   804 GGGGMYPPLIPTRVPTPSNGAPEIPARPQV--PKRP 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	189/238 (79%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	197/287 (69%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	66/108 (61%)
		GED	649..739	CDD:460495	57/89 (64%)
		PHA03247	<737..868	CDD:223021	42/144 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870		42/140 (30%)
dyn-1	NP_001024332.1	DLP_1	31..296	CDD:206738	216/264 (82%)
		Dynamin_M	217..502	CDD:460033	195/284 (69%)
		PH_dynamin	518..628	CDD:269958	68/114 (60%)
		GED	648..739	CDD:128597	58/90 (64%)