DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Y73F8A.35 and CG31933

DIOPT Version :9

Sequence 1:	NP_001255870.1	Gene:	Y73F8A.35 / 178438	WormBaseID:	WBGene00013539	Length:	654	Species:	Caenorhabditis elegans
Sequence 2:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	168/687 - (24%)
Similarity:	258/687 - (37%)	Gaps:	175/687 - (25%)

- Green bases have known domain annotations that are detailed below.

Worm    65 DRCDLPDYEIWNDDILKYLN---MDETPITKCNIAPPLTY----LINGSWN----------AVNA 112
            |.|.:...::.|..|.||.:   .|:....||   |..|:    :.||.|.          ...:
  Fly    46 DGCRIIAMDVMNPTIAKYTDWEWKDKRFYLKC---PHQTWFRTEVANGDWYLKLTRDIDRILQES 107

Worm   113 SAGYDCKTRCHWRKDDRTNFIGNWNS-----TPGPVDCEF----------LEAICLK--DNLKVY 160
            ...:|.:.:|:|   .|....|.|.:     |..|::..:          :...||.  .|..::
  Fly   108 DLTHDWQIKCYW---FRIKIKGRWRAKIYGPTMFPLEYPYALKVPKGLRHMRVKCLNTFTNKTLH 169

Worm   161 GYMHSQIIPTPPITPKVDVSKLQQYD-------------VTVILLDSLAHAQALRSLPRAISYMT 212
            ...|..|.|.|....|...:.|:.:|             |.::.|||::|...||.:||.:.||.
  Fly   170 DDAHFFIQPPPEKLLKKPPATLKYWDGEKHSSGATSPISVMILGLDSVSHLNLLRQMPRTVRYMR 234

Worm   213 SHMSAVVFPYVNKVGENSRSNGVPLWFGKSLEKLDKSLFDEEDVTVDWTHEYMCNEFKDNETSIF 277
            .:||.|.|...||:|.|:..|.:.|..|.|..:.:          ..|..:    :..||...|:
  Fly   235 QNMSQVEFWGFNKIGTNTYPNLIALLTGLSAAESE----------AYWVRQ----KCMDNLPLIW 285

Worm   278 NEFRDYGYKTLLAEDWAEGTLNFPNCKGFDNPPIDHYMRPFQNALERPHHGEFITRNHLSPGNLT 342
            .||:..||.|..|||.|..::.:....||..|..|:.:..|...|........::..|...   .
  Fly   286 KEFKRAGYNTSFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDTHCMG---E 347

Worm   343 REHHNTLLEYLSKFM---NAYPNEKKFSWIWASHLGHDSMNGFSHADNDFYNFLVKHREKLD--- 401
            |...:.|||...:.:   ..||   .||:.|.::..|:..|....||..|...|    ..||
  Fly   348 RAFMDILLEMNDRLLPHTQRYP---FFSFYWWANGFHEFFNSPRLADGRFERLL----RSLDDAG 405

Worm   402 ---NSFVILMGDHGPRFGANRKTVSGELEVHNPFLGISIPKALR-KTTEILSLMKGNAKKLQTHY 462
               |:.:..|.|||.|:|..|.:..|.:|...|||.:..||.:| |....:..:.|||..|.|.|
  Fly   406 ITNNTIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSLVGNAHSLVTTY 470

Worm   463 DTRATILDILKYQSTTNFLDT----EILKIPGEKGFSFIRKQPDTP------------RNCKTMP 511
            |...|:..||:..|..:...|    |:.|:.|.:          ||            |||.|..
  Fly   471 DLHETLKHILEPSSLEDTSITQKTEELWKLKGSQ----------TPRAVSLFLPIPPWRNCNTSH 525

Worm   512 IPIQYCLC-------KFNR-TTESIHSDLAHSMAKALTAAVNTELENGKLQSRCIKMEYSII--L 566
            ||.::|||       :.|| .|:|         |..:...||.           :.:||.:.  |
  Fly   526 IPSKFCLCHKQIPIPESNRVVTKS---------ASIIIDYVNQ-----------LMVEYPVCIPL 570

Worm   567 SLDRLDEKF-----RGSILY------------------------TIVVEMK-KPSNAWFKANIKM 601
            .||.::..:     |....|                        .|||.:| ||.||:|:...:.
  Fly   571 QLDSIESAYFAAPQRDDDFYIEKGHKNVYPEKGPFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRR 635

Worm   602 LSTGELKVLGIIERV-NEYGQTAHCIKSEYHRPYCFC 637
            ..: :|.::|.:.|| .|..:...||.:....|:|.|
  Fly   636 QGS-KLSLVGEVVRVGGEGNRNNDCIDNPLLEPFCHC 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Y73F8A.35	NP_001255870.1	DUF229	89..557	CDD:281053	135/545 (25%)
Y73F8A.35	NP_001255870.1	ALP_like	185..475	CDD:293745	88/312 (28%)
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	132/518 (25%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	87/298 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020