DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mug2 and Tep1

DIOPT Version :9

Sequence 1:	XP_006505762.1	Gene:	Mug2 / 17837	MGIID:	99836	Length:	1490	Species:	Mus musculus
Sequence 2:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	1519	Identity:	381/1519 - (25%)
Similarity:	660/1519 - (43%)	Gaps:	258/1519 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 LFSVLLAFLPSASSLNGDSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLVSQT-GRRNLF 74
            |..|||:        |.:..|.||.|..|.:.:...:.:.:::...|..|:.||...: ..|...
  Fly    11 LHCVLLS--------NANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYV 67

Mouse    75 DELVVDKDLFQCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVLVKNKESVVFVQTDKPVYK 139
            |   |.....:.|.|.||.|...|.|  |.|...|.. ||.....:......:.:::|:||..||
  Fly    68 D---VQSMSSKSVRFDIPKLTEGDYE--LKVMGSGGI-EFQNSTKLSFAPDLNWLYIQSDKATYK 126

Mouse   140 PGQSVKFRVVSMDKTLRPLNELLPLAY-IEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPY 203
            ||..::|||:.:||..||.....|:.. |.|..:|.|..|:|||...|:......|:..|:.|.:
  Fly   127 PGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNW 191

Mouse   204 KIVVHKQSGVKEEHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGKPVPGQVKISI 268
            .:....|...|..:...|.::|:|:|.|.:.....::.:...::.|:..:||:.|||.|.|..:|
  Fly   192 TVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI 256

Mouse   269 CHETEAGCKEVNSKLDNNGCSTQEVNI---TELQSKKRNYEVQLFHVNATVTEEGTGLEFNGYGT 330
                |....|.:..:|.      |||:   ....:|:      |..:.|.||||.|.::.||...
  Fly   257 ----EGSSTEQSLPIDG------EVNVEFPISATAKR------LLKITAIVTEELTDIKHNGTAY 305

Mouse   331 TKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVL------GYTSATTT 389
            ..:.:..:||..|...:|:|.|:....|..:.::.|.|:.:....:...||      .::::.
  Fly   306 VTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASL-- 368

Mouse   390 DQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSCYFFYCM-EERYASAEHVAYAVYSLSKSYIYLVK 453
             |:.:|            :.||.:    .::|.  .|: ...:.:||::...:|.|:|..:..:.
  Fly   369 -QNSIA------------TEHIML----PETCQ--SCLVTSTFDTAENIERYIYKLNKPLMIAIN 414

Mouse   454 ETSSILPCNQIHTVQAHFILKGDLGVLKELVFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGNFDL 518
            ....          |...:||  :.::.:....|.::   :::..||....:.......|.:.::
  Fly   415 TKKP----------QLRKLLK--INIISDTYLPYFIL---TVVARGNIVLSLFQEMKEKKKSQEI 464

Mouse   519 EIPVEFSMAPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASP 583
            |....|::.|.|.:.::.|: ||.:::|....:||:...|.::: .:::::||..:..|:|..:|
  Fly   465 EFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNP 527

Mouse   584 QSLCGLRAVDQSVLLLKPEDELSPSWIYNLPGMQHNKFIPSSSLSEDREDCILYSSWVAEKHTDW 648
            .|..||..||||||||:..::|:...|.|                    :...||:
  Fly   528 HSFVGLLGVDQSVLLLRSGNDLNRDLILN--------------------NLATYST--------- 563

Mouse   649 VPHGREKDVYRYVEDMDLKAFTNLKIKLPKI---CFDSAPMSGPRGKF--DLAFSSEV---SGTL 705
                            ||...||..|.:.:.   |:.:...:...|..  ...|.:|.   ||.:
  Fly   564 ----------------DLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTKNSGPV 612

Mouse   706 QKGSSKRPQPEEPPREDPPPKDPLAETIRKYFPETWVWDIVT-VNSTGVAEVEMTVPDTITEWKA 769
            ....|.|.|...||             :||.|||||::..:| |.:.|...::.|||||:|.|..
  Fly   613 PIVGSTRAQASLPP-------------VRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVI 664

Mouse   770 GALCLSNDTGLGLS-SVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEAS 833
            ....||..:||.:: :...::.|||||:..:|||||.|||...:...|.|||...::..|.::.|
  Fly   665 TGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNS 729

Mouse   834 P-DFTAVPVGDDHDSYCLSANGRHTSSW-----------LVTPKSLGNVNFSVSVEAQQSSEPCG 886
            . .:..:...:.:.|..|....|..:.|           ::.||.:|.....::..::.:.
  Fly   730 DGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAG---- 790

Mouse   887 SEVATVPETGRKDTVVKVLIVEPEGIK-----------QEHTFNSLFCASDAEISEKMSLVLPPT 940
                        |.:.::|.||.:|::           |.....||.......|.||..     .
  Fly   791 ------------DRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKAD-----N 838

Mouse   941 VVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTK 1005
            |::.|....|.|.|...:..:::..:|:|:|.|||||||..|.|:|..|.||....:..|:|:.|
  Fly   839 VIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENK 903

Mouse  1006 ALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFT 1070
            |..::..|||.|||||..|||:||:|..  :..|:|||||:|::||.||..:|.||::.:.....
  Fly   904 AKRYVETGYQIELNYKRNDGSFSAWGQH--DALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLD 966

Mouse  1071 WLSQQQKDNGCFRSSGSLFHNDIKGGVDDEMTLSAYITMALLESS--LPARHPVVSKALSCLESS 1133
            :|..:|..:|.|:..|.:.||    .....:.|::::.:...|:.  :|....|:.:|:..:
  Fly   967 FLVSRQSTDGKFKELGMVIHN----SHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFV--- 1024

Mouse  1134 WKTIEQGRNANFVYTKALMAYAFALAGNQDKRN--EILKSLDEEAIKEDNSIHWERPQKPRKSEH 1196
               :.:...:|..|..|:.|.|.:||.|   ||  ::|..||:.|.:..:...|....|.:.|
  Fly  1025 ---VTEVHQSNEPYDLAIAALALSLARN---RNAYKVLDKLDKLATRRGDHKWWTGSDKCKSS-- 1081

Mouse  1197 NLYKPQASSVEVEMNAYVVLARLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALD 1261
                      |||..:||:||.|....:..|:.:      :.||..::||||||.|:|||||.:.
  Fly  1082 ----------EVETTSYVLLALLEHNISDEPKPI------VDWLISKRNSNGGFVSSQDTVVGIM 1130

Mouse  1262 ALSKYGAVTFSRRQKTSLVTIQ--STGSFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCV 1324
            ||:||   .......|..:.|:  ......:..:|...|...:|...||:...:..:...|:|..
  Fly  1131 ALTKY---ELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRA 1192

Mouse  1325 YAQTTLRYNMHLEKQQSAFALRVQTVPLTCNNPKGHNSFQISLEI--SYT-----GSRPASNMVI 1382
            ..|.|.|||:..::.:.:|       .||....|.|.. ::.|.|  :||     .....:||.:
  Fly  1193 QVQLTYRYNVATKEARPSF-------KLTTTVKKSHKG-RLILGICGTYTPIAASERNKTTNMAL 1249

Mouse  1383 ADVKMLSGFI-PLKPTVKKLERLEHISRTEVSNNN--VLLYLDQVT---NQTLAFSFIIQQDISV 1441
            ..|::.||:: .::| ...:|.:..:.|.|..|.:  |.:|.::::   .:.|....|...  :|
  Fly  1250 MQVQLPSGYVCDIEP-FADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTH--AV 1311

Mouse  1442 RNLQPAIVKVYDYYETDEVAYAEY 1465
            .||:|:.|::||||.|:..|...|
  Fly  1312 ANLKPSWVRLYDYYATERSATEFY 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mug2	XP_006505762.1	A2M_N	129..221	CDD:376626	29/92 (32%)
		MG3	223..299	CDD:375334	19/78 (24%)
		MG4	340..434	CDD:375332	16/100 (16%)
		A2M_N_2	459..599	CDD:377903	32/139 (23%)
		A2M	740..830	CDD:365945	34/91 (37%)
		A2M_2	960..1266	CDD:239227	102/309 (33%)
		A2M_recep	1378..1465	CDD:369460	25/92 (27%)
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	28/84 (33%)
		A2M_N_2	411..542	CDD:285005	31/147 (21%)
		A2M	634..726	CDD:278630	34/91 (37%)
		A2M_2	859..1135	CDD:239227	102/308 (33%)
		A2M_comp	910..1135	CDD:284982	82/257 (32%)
		A2M_recep	1245..1335	CDD:284981	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840031
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650