DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mug1 and Tep1

DIOPT Version :9

Sequence 1:	XP_006505761.1	Gene:	Mug1 / 17836	MGIID:	99837	Length:	1483	Species:	Mus musculus
Sequence 2:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	1551	Identity:	383/1551 - (24%)
Similarity:	667/1551 - (43%)	Gaps:	303/1551 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MWKSRRAQLCLFSVLLAFLHSASLLNGDSKYMVLVPSQLYTETPEKICLHLYQLNETVTVTASLV 65
            :|      |.|.|.:   ||...|.|.:..|.||.|..|.:.:...:.:.::....|..|:.||.
  Fly     2 LW------LILSSTI---LHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLT 57

Mouse    66 --SQSGRKNLFDELVLDKDLFQCVSFIIPRLSSSDEEDFLYVDIKGPTH-EFSKRKAVLVKNKES 127
              |.:.||.:..:.:..|.    |.|.||:|:..|.|    :.:.|... ||.....:......:
  Fly    58 GPSLNSRKYVDVQSMSSKS----VRFDIPKLTEGDYE----LKVMGSGGIEFQNSTKLSFAPDLN 114

Mouse   128 VVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELLPLAY-IEDPKKNRIMQWRDIKTENGLKQMS 191
            .:::|:||..||||..::|||:.:||..||.....|:.. |.|..:|.|..|:|||...|:....
  Fly   115 WLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGE 179

Mouse   192 FSLAAEPIQGPYKIVVHKESGEKEEHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTY 256
            ..|:..|:.|.:.:....:...|..:...|.::|:|:|.|.:.....::.:...:..|...:||:
  Fly   180 LQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTF 244

Mouse   257 GKPVPGHVKINVCRETETGCREVNSQLDNNGCSTQEVNI---TELQSKKRNYEVQLFHVNATVTE 318
            .|||.|||...:    |....|.:..:|.      |||:   ....:|:      |..:.|.|||
  Fly   245 KKPVKGHVVATI----EGSSTEQSLPIDG------EVNVEFPISATAKR------LLKITAIVTE 293

Mouse   319 EGTGLEFSRSGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEKVFIK-----A 378
            |.|.::.:.:....:.:..:||..|...:|:|.|:....|..:.::.|.|:.:....:.     .
  Fly   294 ELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCC 358

Mouse   379 QELSYTSATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYFYCMEERHASAKHVAYAVYS 443
            |.....||:..:........:..||               .||    .:.....:|:::...:|.
  Fly   359 QVSKNFSASLQNSIATEHIMLPETC---------------QSC----LVTSTFDTAENIERYIYK 404

Mouse   444 LSKS-YIYLDTETSSILPCNQIHTVQAHFILKGDLGVLKELIFYYLVMAQGSIIQTGNHTHQVEP 507
            |:|. .|.::|:..           |...:||  :.::.:....|.::   :::..||....:..
  Fly   405 LNKPLMIAINTKKP-----------QLRKLLK--INIISDTYLPYFIL---TVVARGNIVLSLFQ 453

Mouse   508 GEAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPA 572
            .....|....:|....|::||.|.:.::.|: ||.:::|....:||:...|.::: .:|:::||.
  Fly   454 EMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPR 516

Mouse   573 SQTRLQVTASPQSLCGLRAVDQSVLLLKPESELSPSWIYNLPGMQQNKFVPSSRLSEDQEDCILY 637
            .:..|:|..:|.|..||..||||||||:..::|:...|.|             .|:....|.::.
  Fly   517 DEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILN-------------NLATYSTDLVIL 568

Mouse   638 SSWLAEKHTNLVPHGTEKDVYR-----YVED---------MGLTAFTNLMIKLPIICFDYGMVPI 688
            :      :.|:       ::||     |...         :|.|.|.|...|      :.|.|||
  Fly   569 T------NANI-------NIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTK------NSGPVPI 614

Mouse   689 -SAPRVEFDLAFTPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPETWVWDIVT-VNST 751
             .:.|.:..|                    ||             :||.|||||::..:| |.:.
  Fly   615 VGSTRAQASL--------------------PP-------------VRKLFPETWLFSNITDVGAN 646

Mouse   752 GLAEVEMTVPDTITEWKAGALCLSNDTGLGLS-SVVPLQAFKPFFVEVSLPYSVVRGEAFMLKAT 815
            |...::.|||||:|.|......||..:||.:: :...::.|:|||:..:|||||.|||...:...
  Fly   647 GEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVI 711

Mouse   816 VMNYLPTSMQMSVQLEASPDFTAVPVGDDQDSYC---------------------LSANGRHTSS 859
            |.|||...::..|.::.|         |.|..:.                     :.||.....|
  Fly   712 VFNYLGMDVKAKVLMDNS---------DGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGIS 767

Mouse   860 WLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQEHTFSSLFCA 924
            :::.||.:|.....::|.::.:.                |.:.::|.||.:|:::....:.|.
  Fly   768 FMIRPKKVGLTTLKITAISKYAG----------------DRLHQILKVEADGVQKYVNKAVLI-- 814

Mouse   925 SDAEISEKMSLVLPP----------TVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQNM 979
             :.:...:.||. ||          .|::.|....|.|.|...:..:.:..:|:|:|.|||||||
  Fly   815 -NVQRLNRRSLA-PPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNM 877

Mouse   980 VLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLT 1044
            ..|.|:|..|.||....:..|:|:.||..::..|||.|||||..|||:||:|..  :..|:||||
  Fly   878 FNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQH--DALGSTWLT 940

Mouse  1045 AFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITM 1109
            |:|::||.||..:|.||::.:.....:|..:|..:|.|:..|.:.:|:.    ...:.|::::.:
  Fly   941 AYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLL 1001

Mouse  1110 ALLESS--LPATHPVVSKALSCLESSWKTIEQERNASFVYTKALMAYAFALAGNQNKRDEILKSL 1172
            ...|:.  :|....|:.:|:..:      :.:...::..|..|:.|.|.:||.|:|.. ::|..|
  Fly  1002 TFFENEEYMPKYKHVIDRAVEFV------VTEVHQSNEPYDLAIAALALSLARNRNAY-KVLDKL 1059

Mouse  1173 DEEAIKENNSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTAQPAPSPEDLTLSMSTI 1237
            |:.|.:..:...|....|.:            |:|||..:||:||.|....:..|:.:      :
  Fly  1060 DKLATRRGDHKWWTGSDKCK------------SSEVETTSYVLLALLEHNISDEPKPI------V 1106

Mouse  1238 MWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRSQKTTLVTIQSTGSFSQKF---------- 1292
            .||..::||||||.|:|||||.:.||:||           .|.:..||.:...:|
  Fly  1107 DWLISKRNSNGGFVSSQDTVVGIMALTKY-----------ELQSHASTEAIDIEFWHLNEDKKHV 1160

Mouse  1293 QVENSNRLLLQQVALPDIPGDYTISVSGEGCVYAQTMLRYNMHLEKQLSAFAIWVQTVPLTCNNP 1357
            :|...|...:|...||:...:..:...|:|....|...|||:..::...:|       .||....
  Fly  1161 RVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSF-------KLTTTVK 1218

Mouse  1358 KGHNSFQISLEI--SYT-----GSRPASNMVIADVKMLSGFI-PLKPTVKKLERLEHVSRTEVSN 1414
            |.|.. ::.|.|  :||     .....:||.:..|::.||:: .::| ...:|.:..|.|.|..|
  Fly  1219 KSHKG-RLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEP-FADIEAISDVKRVETKN 1281

Mouse  1415 NN--VLIYLDQVT---NQTLAFSFIIQQDIPVRNLQPAIVKVYDYYETDEMAFAEY 1465
            .:  |.||.::::   .:.|....|...  .|.||:|:.|::||||.|:..|...|
  Fly  1282 EDTEVHIYFEKLSPGDRKCLTLEAIYTH--AVANLKPSWVRLYDYYATERSATEFY 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mug1	XP_006505761.1	A2M_N	129..221	CDD:376626	28/92 (30%)
		MG3	223..299	CDD:375334	19/78 (24%)
		MG4	340..439	CDD:375332	16/103 (16%)
		A2M_N_2	449..599	CDD:377903	36/149 (24%)
		A2M	740..830	CDD:365945	33/91 (36%)
		A2M_2	960..1266	CDD:239227	99/307 (32%)
		A2M_recep	1378..1465	CDD:369460	27/92 (29%)
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	27/84 (32%)
		A2M_N_2	411..542	CDD:285005	35/148 (24%)
		A2M	634..726	CDD:278630	33/91 (36%)
		A2M_2	859..1135	CDD:239227	99/306 (32%)
		A2M_comp	910..1135	CDD:284982	79/255 (31%)
		A2M_recep	1245..1335	CDD:284981	27/92 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840035
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650