DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-3 and Drice

DIOPT Version :9

Sequence 1:	NP_001255708.1	Gene:	ced-3 / 178272	WormBaseID:	WBGene00000417	Length:	503	Species:	Caenorhabditis elegans
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	113/375 - (30%)
Similarity:	167/375 - (44%)	Gaps:	81/375 - (21%)

- Green bases have known domain annotations that are detailed below.

Worm   129 HRDSVSSVSSFTSYQDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGY 193
            |.|::.||.|            ..:.|..|.:...|.|.|..:...      ||         ||
  Fly    26 HTDALGSVGS------------GGAGSSGLVAGSSHPYGSGAIGQL------AN---------GY 63

Worm   194 SSSRNRSFSKASGPTQYIFHEEDMNFVDAPTISRVFDEKTMYRNFSSPRGMCLIINNEHFEQMPT 258
            ||. :.|:.|              |.....|.....:....::|    |||.||.|:|||| :||
  Fly    64 SSP-SSSYRK--------------NVAKMVTDRHAAEYNMRHKN----RGMALIFNHEHFE-VPT 108

Worm   259 ---RNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFAKHESHGDS-AILV-ILSHGEE 318
               |.||..|.:|||.:.:.:.:.|....:...:.:|.|| ::|..::|.|| .||| ||||||.
  Fly   109 LKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTI-EYAASQNHSDSDCILVAILSHGEM 172

Worm   319 NVIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRG 383
            ..|. ..|.......|:....|.:.|.||.|||:.|:|||:|:|.|.|           ..::|.
  Fly   173 GYIY-AKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGG-----------VTMQRS 225

Worm   384 WDNRDGPLFNFLGCVRPQVQQVWRKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTH 448
            ....||.            ..:..|.|..||.||||:|...:.||||:.|||||:|::|...:.:
  Fly   226 QTETDGD------------SSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAAN 278

Worm   449 AKDMDVVELLTEVNKKVACGFQT----SQGSNILKQMPEMTSRLLKKFYF 494
            .|.:|::.|||.|.::||..|::    :...:..||:|.:|:.|.:...|
  Fly   279 GKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-3	NP_001255708.1	CARD	2..90	CDD:128424
ced-3	NP_001255708.1	CASc	235..496	CDD:214521	93/269 (35%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	93/273 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162595
Domainoid	1	1.000	130	1.000	Domainoid score	I3239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I3180
Isobase	1	0.950	-	0	Normalized mean entropy	S5027
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000242
OrthoInspector	1	1.000	-	-		mtm4766
orthoMCL	1	0.900	-	-		OOG6_103710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3066
SonicParanoid	1	1.000	-	-		X460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770