DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-3 and Dredd

DIOPT Version :9

Sequence 1:	NP_001255708.1	Gene:	ced-3 / 178272	WormBaseID:	WBGene00000417	Length:	503	Species:	Caenorhabditis elegans
Sequence 2:	NP_477249.3	Gene:	Dredd / 31011	FlyBaseID:	FBgn0020381	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	73/286 - (25%)
Similarity:	114/286 - (39%)	Gaps:	84/286 - (29%)

- Green bases have known domain annotations that are detailed below.

Worm   243 GMCLIINNEHF--------------EQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLL 293
            |:.||||.:.|              :.:..|:||..||:.|..:|..|||.|...||:...|::.
  Fly   259 GIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIE 323

Worm   294 TIRDFAKHESHGDSAILVILSHGEENVIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQAC 358
            .||.........||.::.|||||.|..:...:.|.:...:|.|||  .:...|..|||::.:|||
  Fly   324 RIRSACDRSLVRDSLVVFILSHGFEEAVYASNSIAMKITDIEDLL--CSYDTLYYKPKLLIIQAC 386

Worm   359 RGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQVWRKKPSQ----------- 412
                                                      |.:.|.:|||::
  Fly   387 ------------------------------------------QEKLVHKKKPNELFRIDVTTVSP 409

Worm   413 ---ADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLT----EVNKKVACGFQ 470
               .|:|.|.:|...|.:.|::..|||||.::|:.....:....:.::||    ||:||
  Fly   410 DQHIDMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKK------ 468

Worm   471 TSQGSNILKQMPEMTSRLLKKFYFWP 496
              :|||....:|.:.|...:..||.|
  Fly   469 --RGSNDESMVPNVKSTFRQHVYFPP 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-3	NP_001255708.1	CARD	2..90	CDD:128424
ced-3	NP_001255708.1	CASc	235..496	CDD:214521	72/284 (25%)
Dredd	NP_477249.3	CASc	252..492	CDD:294037	72/284 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840