Protein Alignment DYNC1I1 and Sdic1

DIOPT Version :10

• Sequence 1: NP_004402.1
• Gene: DYNC1I1 / 1780
• HGNCID: 2963
• Length: 645
• Species: Homo sapiens
• Sequence 2: NP_524670.2
• Gene: Sdic1 / 43984
• FlyBaseID: FBgn0067861
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 251/521 - (48%)
• Similarity: 330/521 - (63%)
• Gaps: 65/521 - (12%)

Human   148 LGVSKVTQVDFLPREVVSYSKETQT--------PLATHQSEEDEEDEEMVESKVGQDSELE---- 200
            |.|..|...:..|:|.:.|:|:|||        .:....::.|:|:..:.....|..|:|.
  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90

Human   201 -----------------NQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAED 248
                             ...|:.|||: ...||:||:||.|:.||.|..|..|..|||||||:|:
  Fly    91 THGLPTVKDVAPAITPLEIKKETEVKK-EVNELSEEQKQMIILSENFQRFVVRAGRVIERALSEN 154

Human   249 SDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDA 313
            .||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||:|||::
  Fly   155 VDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEES 219

Human   314 PHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPV 378
            |:|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:
  Fly   220 PNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPI 284

Human   379 QRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVT 443
            ||||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|
  Fly   285 QRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAIT 349

Human   444 GMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTS 508
            .||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:||
  Fly   350 SMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTS 414

Human   509 SFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVH----PALFACVDGMGRLDLWNLNNDTEVP 569
            |.|||:|||:.|..|||||||..      :.||||.    |.                      |
  Fly   415 SIDWTIKLWSLKDTKPLYSFEQY------IAWSPVRRQRPPG----------------------P 451

Human   570 TASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGE-LAVPHNDEWTRFARTLVEIRANRA 633
            ..:....||.||.|..|..:|  :.:||..|:::||||.| ||.|..|||:||...|.||:.|:.
  Fly   452 DKTQPRHGAPALRRDSWTPSG--LCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQG 514

Human   634 D 634
            |
  Fly   515 D 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58
		Interaction with DCTN1. /evidence=ECO:0000250	2..123
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..125
		Dynein_IC2	143..173	CDD:463291	10/32 (31%)
		Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274	147..163		4/14 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..221		16/80 (20%)
		WD 1	285..334		31/48 (65%)
		WD40 repeat	291..337	CDD:293791	30/45 (67%)
		WD40	<318..607	CDD:441893	159/292 (54%)
		WD 2	338..378		30/39 (77%)
		WD40 repeat	346..385	CDD:293791	29/38 (76%)
		WD 3	387..428		31/40 (78%)
		WD40 repeat	393..434	CDD:293791	28/40 (70%)
		WD 4	437..477		21/39 (54%)
		WD40 repeat	442..481	CDD:293791	20/38 (53%)
		WD 5	482..527		25/44 (57%)
		WD40 repeat	488..529	CDD:293791	24/40 (60%)
		WD 6	530..570		5/43 (12%)
		WD40 repeat	535..573	CDD:293791	6/41 (15%)
		WD 7	576..615		18/39 (46%)
		WD40 repeat	581..607	CDD:293791	9/25 (36%)
Sdic1	NP_524670.2	Dynein_IC2	21..51	CDD:463291	9/24 (38%)
		WD40	196..>445	CDD:475233	162/254 (64%)
		WD40 repeat	196..245	CDD:293791	32/48 (67%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..386	CDD:293791	19/36 (53%)
		WD40 repeat	393..435	CDD:293791	24/41 (59%)