DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYNC1I1 and Dnai2

DIOPT Version :9

Sequence 1:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens
Sequence 2:	NP_001261723.1	Gene:	Dnai2 / 39318	FlyBaseID:	FBgn0036195	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	116/536 - (21%)
Similarity:	202/536 - (37%)	Gaps:	109/536 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   127 DTDPSVLQLQSDSELGRR-LHKLGVSKVTQVDFLPREVVSYSKET-----QTPLATHQSEEDEED 185
            |.|..|....|:.||.:. :.|..|.:|||          |:.:|     .|..||::|
  Fly    20 DKDEVVFTENSNPELVKSYILKNPVDRVTQ----------YAGQTSLSVANTERATYKS------ 68

Human   186 EEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILH---SEEFLIFFDRTIRVIERALAE 247
            ..:..::.|...::...|.:|.|:.....|..|....|:::   ..|..|..:..:.:.|... |
  Fly    69 TGITHNEGGWPKDINMHDPEQTVRYKRKIEKDENYITQVMNLTKPMEHYIHQNNAVNIYENYF-E 132

Human   248 DSD--------------IFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWS-----KHRVVTC- 292
            :.|              ::.|.:..::..|        :||         ||     |..|..|
  Fly   133 NLDPAPLPEPCKSRTVNVYRDPNPIKVPVK--------HLS---------WSPDGGIKMAVSHCD 180

Human   293 MDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVC--FARFHPNL 355
            |.:..........||....:.|:||          |....|:        |..||  :.:..|..
  Fly   181 MRFQGDKSNQKCNSYIWEVENPNEP----------FLTLEPK--------VPCVCLEYNQKDPTS 227

Human   356 VVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSL 420
            :|.|.|:||:..||.| |.:.||..:. ....|..||..|....:::.....:..:||::..|..
  Fly   228 LVSGMYNGQVAAWDTR-HGKLPVMISE-REVCHRDPVNSVLWNNSKSGTEFFSGGSDGQVLWWDT 290

Human   421 DMLSTPQESMELVYNK------SKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHG----SKAG 475
            ..|:.|.:.:.:...|      |:...::.:.:.|.....|:.|:|.|.:::..|.|    .|..
  Fly   291 RKLTEPLDRLLMDPVKSDDQDLSRSYGISVLEYETTIPTRFMAGTEMGMLFSCNRKGKTPTEKIQ 355

Human   476 IGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWT--TKHNKPLYSFEDNADYVYDV 538
            |..:.  |.|||..|..:.|     |...|:|.. ||..::|:  .:.:..::: :.::..:.|.
  Fly   356 IRMMC--HLGPVYAITRNPA-----FVKNFLTVG-DWCARIWSEDCRESSIIWT-KSSSSMLTDG 411

Human   539 MWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIW 603
            .||....:.|......|.||.|:|......|..:|.: ....|..||..:.||.|:.|...|..:
  Fly   412 AWSYTKVSQFFITRMDGVLDTWDLLQQQNEPVLTVKV-CDEPLYCVRTNENGKFVSCGSQLGATF 475

Human   604 VYDVGELAV--PHNDE 617
            :.:|.:..|  ..||:
  Fly   476 LVEVSDNMVMSAKNDK 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Interaction with DCTN1. /evidence=ECO:0000250	2..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125
		Dynein_IC2	147..173	CDD:371592	7/30 (23%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		11/56 (20%)
		WD40	283..606	CDD:392136	79/342 (23%)
		WD 1	285..334		11/54 (20%)
		WD40 repeat	291..337	CDD:293791	9/46 (20%)
		WD 2	338..378		13/41 (32%)
		WD40 repeat	346..385	CDD:293791	14/40 (35%)
		WD 3	387..428		9/40 (23%)
		WD40 repeat	393..434	CDD:293791	6/40 (15%)
		WD 4	437..477		9/43 (21%)
		WD40 repeat	442..481	CDD:293791	9/42 (21%)
		WD 5	482..527		12/46 (26%)
		WD40 repeat	488..529	CDD:293791	8/42 (19%)
		WD 6	530..570		9/39 (23%)
		WD40 repeat	535..573	CDD:293791	10/37 (27%)
		WD 7	576..615		10/40 (25%)
		WD40 repeat	581..607	CDD:293791	8/25 (32%)
Dnai2	NP_001261723.1	WD40	<160..482	CDD:225201	83/368 (23%)
		WD40 repeat	162..208	CDD:293791	15/72 (21%)
		WD40	212..469	CDD:295369	64/276 (23%)
		WD40 repeat	215..254	CDD:293791	14/40 (35%)
		WD40 repeat	262..304	CDD:293791	7/41 (17%)
		WD40 repeat	318..355	CDD:293791	8/36 (22%)
		WD40 repeat	365..401	CDD:293791	9/41 (22%)
		WD40 repeat	408..433	CDD:293791	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810