DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYNC1I1 and CG14838

DIOPT Version :9

Sequence 1:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	133/675 - (19%)
Similarity:	231/675 - (34%)	Gaps:	243/675 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   129 DPSVLQLQSDSELGRRLHKLGVSKVTQ------VDFLPREVVSY-------------------SK 168
            :|..:::||...:....|.....::|:      ::.||.|.:.:                   .:
  Fly   217 EPIDVEIQSVYPIQMPRHVAFDYRMTRDVRDGVLELLPNENIKWENVTKKRVNVSVQSAPPKIER 281

Human   169 ETQT-------PLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEK----- 221
            |.||       ..:.:..|.|:||.|:.|:.|.     |.::||:  .:|.|....|.||
  Fly   282 EQQTNPTFPSNAWSQYLYEIDDEDLELDETDVD-----EEEEKKK--AQAKPGTYVEPEKKPPEM 339

Human   222 ----QQILHSEEFL---IFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQF 279
                :.:|::.||.   .:.|....:..|.:.:       |:...|:|    ....||:|
  Fly   340 SAQIEMLLNTLEFNQIDSYRDDYSLISSRQVVQ-------YTNPYLQE----FLCFANIS----- 388

Human   280 YDEHWSKHRVVTCMDWSLQYPE---LMVASY-----------NNNED----APHEPDGVALVW-- 324
                .|..|.|...||   ||:   |:..||           .|..|    |..||:.| |:|
  Fly   389 ----KSNKRFVAGYDW---YPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPV-LLWSF 445

Human   325 --NMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAA 387
              |:.:|     ..|.......::.|..|:.::::||:.:||:||||.:.......:...|:||.
  Fly   446 SDNLNYK-----LEFEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQ 505

Human   388 HTHPVY-------------------------C------------------------VNVVGTQNA 403
            ..:.:.                         |                        .|....:|.
  Fly   506 AKYRIMIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNH 570

Human   404 HN-LITVSTDGKMCSWSLD--------------MLS---TPQES------MELVYNKSKPVAVTG 444
            |. .:|.:.||.:..|.||              ||.   |..||      ::..||...|..:||
  Fly   571 HKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITG 635

Human   445 MAFPT--------------GDVNNFVVGS---------EEGTVYTACRHGSKAG-IGEVFEG--- 482
            :...|              .:.:|:.:.:         :...|.|...|.|:.. .|...||
  Fly   636 IIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEAT 700

Human   483 ------------HQGPVTGINCHMAVGPIDFSHLFVTSSFDWTV-KLWTTKHN-KPLYSFEDNAD 533
                        |.|||..:.    ..|. :..||  :|...|: .:|...:| .|:: :...|.
  Fly   701 EVINSSIPFAMVHDGPVVMVK----KNPF-YPELF--ASIGRTILAIWKEDYNYSPIF-WRKRAC 757

Human   534 YVYDVMWSPVHPAL--FACVDGMGRLDLWNL---NND---TEVPTASVAIEGASALNRVRWAQAG 590
            .:..|.||...||:  ...:||:  |:.|::   ::|   ||:....:    .:|:...|.:...
  Fly   758 DLTAVAWSETRPAVLYLTRIDGI--LEAWDILARDDDACLTEILGGGI----ITAITEHRPSLPH 816

Human   591 KEVAVGDSEGRIWVYDVGELAVPHN 615
            |.:.:||....|.:     :.:||:
  Fly   817 KILGIGDYNSSIRM-----VKLPHS 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Interaction with DCTN1. /evidence=ECO:0000250	2..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125
		Dynein_IC2	147..173	CDD:371592	7/57 (12%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		16/58 (28%)
		WD40	283..606	CDD:392136	94/466 (20%)
		WD 1	285..334		20/70 (29%)
		WD40 repeat	291..337	CDD:293791	17/67 (25%)
		WD 2	338..378		10/39 (26%)
		WD40 repeat	346..385	CDD:293791	11/38 (29%)
		WD 3	387..428		13/107 (12%)
		WD40 repeat	393..434	CDD:293791	15/113 (13%)
		WD 4	437..477		9/63 (14%)
		WD40 repeat	442..481	CDD:293791	9/62 (15%)
		WD 5	482..527		13/61 (21%)
		WD40 repeat	488..529	CDD:293791	8/42 (19%)
		WD 6	530..570		13/47 (28%)
		WD40 repeat	535..573	CDD:293791	12/45 (27%)
		WD 7	576..615		7/38 (18%)
		WD40 repeat	581..607	CDD:293791	5/25 (20%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	58/299 (19%)
		WD40 repeat	462..505	CDD:293791	12/42 (29%)
		WD40 repeat	510..547	CDD:293791	1/36 (3%)
		RE_R_Pab1	807..>863	CDD:286594	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810