DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYNC1I1 and Dic61B

DIOPT Version :9

Sequence 1:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens
Sequence 2:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	147/739 - (19%)
Similarity:	274/739 - (37%)	Gaps:	193/739 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     5 SDLKAELERKKQRLAQIREEKKRKEEERKKKE----------ADMQQKKE--------------- 44
            |:|..||::|...:.|.:.|    |.:.|||:          ||:|.:.:
  Fly    22 SNLDNELKKKSVVVNQTQAE----ESKAKKKDTTHYYSVETLADLQYRSQIKVLEKIYGEEVDMT 82

Human    45 --PVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLV--------PTPMSPS 99
              .:|||:.:::                         |:.::....|.:.        .|..|.:
  Fly    83 PKSIQDDTYVEQ-------------------------FMKYNLNVMHQMTNFTTMVAKSTTRSRT 122

Human   100 SKSVSTPSEAGSQDSGDL--GPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVT--QVDFLP 160
            ..||........|...||  |.|..|:.|:...:|..|:...|  .:.:.....|:|  :.||.
  Fly   123 RSSVRAGIGGNKQSIDDLMNGILYETINWEPYSTVEALEEAYE--PKPYTKSFLKITLRKSDFF- 184

Human   161 REVVSYSKETQTPLAT-----HQSEEDEEDEEMVESKVGQDSELENQDKKQE------------- 207
             |:.|   :|||.:|.     ..:|.|..:.|.:....|:.....:.|.:.:
  Fly   185 -EIHS---QTQTTVAKGSPEGDDAERDNRNYEYLTIGKGKIRRRSDNDAQTDTLLFTTRAVNTIL 245

Human   208 -VKEAPPRELTEEEKQQILH--SEEFLIFFDRTIRVIERALA--EDSDIFFDYSG---------- 257
             .|......::..|....|:  ::||......:::.:..|||  ||:|.|.|...
  Fly   246 ITKATVSSYVSNFEMYDTLNNITKEFATATMSSVKDLTSALAQTEDADTFEDDEAVAEKDKVSSQ 310

Human   258 -----RELEEKDGDVQAGANLSFN------RQF--YD--EHWS---------------------- 285
                 |..|.::..:..|..||.|      |:|  :|  |.|:
  Fly   311 IERLFRSPEFRNAIMYMGRTLSSNTNEAGLRRFRNFDQVERWNAEAEYVYSMNLLFRLVPEPSKD 375

Human   286 KHRVVTCMDWSLQYPELMVASYN-NNEDAPHEP-DGVALVWNMKFKKTTPEYVFHCQSSVMSVCF 348
            :.:.|:.:|:.....:::..:|. .:..:.|.| .|...:|::| ....||..::....|.::.|
  Fly   376 ERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIK-NPGEPERAYYYDVPVTAINF 439

Human   349 ARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVG--TQNAHN-----L 406
            :.|.|:|:..|.|.|.:.:.|..|.:.|||..:..|.:..:.||..:..:.  :.:.|.     .
  Fly   440 SPFLPSLLAIGLYDGSVEVRDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPF 504

Human   407 ITVSTDGKMCSW----SLDMLSTPQESMELVYNKSKPVAV--------------TGMAFPTGDVN 453
            :::|.||.:..:    |..:|...|..:|.|....:.:.|              .|::..|..::
  Fly   505 LSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNRHPQGLSITTHPLH 569

Human   454 N--FVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFS----HLFVTSSFDW 512
            .  :.|.::||.:: .|....:....||...|.|.||         .::||    .||:|...||
  Fly   570 KDIYYVLTDEGCIH-KCSINYQHQYLEVLRCHDGGVT---------VMEFSPWSPKLFLTCGNDW 624

Human   513 TVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG 577
            .|::|.....:||....|....|:...|||.|..:...|: ....::|:...:...|.:...::
  Fly   625 FVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTIIVTVN-RETANVWDFRRNLLRPMSKHKMD- 687

Human   578 ASALNRV-RWAQAGKEVAVGDSEG 600
             |:.|.| |::..|:.:.:|:..|
  Fly   688 -SSFNTVARFSHCGRTLVIGNERG 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		17/79 (22%)
		Interaction with DCTN1. /evidence=ECO:0000250	2..123		28/154 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125		9/31 (29%)
		Dynein_IC2	147..173	CDD:371592	8/27 (30%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		10/70 (14%)
		WD40	283..606	CDD:392136	76/374 (20%)
		WD 1	285..334		8/72 (11%)
		WD40 repeat	291..337	CDD:293791	9/47 (19%)
		WD 2	338..378		11/39 (28%)
		WD40 repeat	346..385	CDD:293791	12/38 (32%)
		WD 3	387..428		8/51 (16%)
		WD40 repeat	393..434	CDD:293791	8/51 (16%)
		WD 4	437..477		7/55 (13%)
		WD40 repeat	442..481	CDD:293791	9/54 (17%)
		WD 5	482..527		15/48 (31%)
		WD40 repeat	488..529	CDD:293791	12/44 (27%)
		WD 6	530..570		8/39 (21%)
		WD40 repeat	535..573	CDD:293791	8/37 (22%)
		WD 7	576..615		7/26 (27%)
		WD40 repeat	581..607	CDD:293791	6/21 (29%)
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	75/367 (20%)
		WD40 repeat	381..429	CDD:293791	9/48 (19%)
		WD40	433..711	CDD:295369	65/291 (22%)
		WD40 repeat	434..473	CDD:293791	13/38 (34%)
		WD40 repeat	552..599	CDD:293791	8/47 (17%)
		WD40 repeat	604..637	CDD:293791	11/41 (27%)
		WD40 repeat	645..682	CDD:293791	8/37 (22%)
		WD40 repeat	691..727	CDD:293791	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810