DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYNC1I1 and Sdic2

DIOPT Version :9

Sequence 1:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens
Sequence 2:	NP_001285481.1	Gene:	Sdic2 / 2768883	FlyBaseID:	FBgn0053497	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	285/517 - (55%)
Similarity:	365/517 - (70%)	Gaps:	31/517 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   148 LGVSKVTQVDFLPREVVSYSKETQT--------PLATHQSEEDEEDEEMVESKVGQDSELE---- 200
            |.|..|...:..|:|.:.|:|:|||        .:....::.|:|:..:.....|..|:|.
  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90

Human   201 -----------------NQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAED 248
                             ...|:.|||: ...||:||:||.|:.||.|..|..|..|||||||:|:
  Fly    91 THGLPTVKDVAPAITPLEIKKETEVKK-EVNELSEEQKQMIILSENFQRFVVRAGRVIERALSEN 154

Human   249 SDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDA 313
            .||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||:|||::
  Fly   155 VDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEES 219

Human   314 PHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPV 378
            |:|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:
  Fly   220 PNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPI 284

Human   379 QRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVT 443
            ||||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|
  Fly   285 QRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAIT 349

Human   444 GMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTS 508
            .||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:||
  Fly   350 SMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTS 414

Human   509 SFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASV 573
            |.|||:|||:.|..|||||||||:|||.||.||||||||||.|||.|||||||||.||||||||:
  Fly   415 SIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASI 479

Human   574 AIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGE-LAVPHNDEWTRFARTLVEIRANRAD 634
            .:.||.|||||.|..:|..|.:||..|:::||||.| ||.|..|||:||...|.||:.|::|
  Fly   480 VVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Interaction with DCTN1. /evidence=ECO:0000250	2..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125
		Dynein_IC2	147..173	CDD:371592	10/32 (31%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		16/80 (20%)
		WD40	283..606	CDD:392136	213/322 (66%)
		WD 1	285..334		31/48 (65%)
		WD40 repeat	291..337	CDD:293791	30/45 (67%)
		WD 2	338..378		30/39 (77%)
		WD40 repeat	346..385	CDD:293791	29/38 (76%)
		WD 3	387..428		31/40 (78%)
		WD40 repeat	393..434	CDD:293791	28/40 (70%)
		WD 4	437..477		21/39 (54%)
		WD40 repeat	442..481	CDD:293791	20/38 (53%)
		WD 5	482..527		25/44 (57%)
		WD40 repeat	488..529	CDD:293791	24/40 (60%)
		WD 6	530..570		33/39 (85%)
		WD40 repeat	535..573	CDD:293791	32/37 (86%)
		WD 7	576..615		21/39 (54%)
		WD40 repeat	581..607	CDD:293791	12/25 (48%)
Sdic2	NP_001285481.1	Dynein_IC2	23..51	CDD:288403	9/24 (38%)
		NtpH	108..>178	CDD:225368	31/70 (44%)
		WD40	196..512	CDD:295369	209/315 (66%)
		WD40 repeat	196..245	CDD:293791	32/48 (67%)
		WD40	<224..523	CDD:225201	199/298 (67%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..435	CDD:293791	48/85 (56%)
		WD40 repeat	441..479	CDD:293791	32/37 (86%)
		WD40 repeat	487..513	CDD:293791	12/25 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140638
Domainoid	1	1.000	377	1.000	Domainoid score	I864
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	600	1.000	Inparanoid score	I957
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm8531
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R314
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800