DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tesmin and mip120

DIOPT Version :9

Sequence 1:	NP_001034746.1	Gene:	Tesmin / 17771	MGIID:	1340029	Length:	475	Species:	Mus musculus
Sequence 2:	NP_001163143.1	Gene:	mip120 / 36499	FlyBaseID:	FBgn0033846	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	145/528 - (27%)
Similarity:	225/528 - (42%)	Gaps:	143/528 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 ALSPAGGAADRDELPVLADAYLGATEPGEPLLRALSPPPGAEVPAALLGDFPGLPELRSPDDAAP 96
            |.|||  ||.:      |:..:|.|  .:.::|::.   |:.||...:........|.:..:|:.
  Fly   453 AASPA--AASK------ANLAMGNT--NKIVMRSMG---GSIVPLPSVQTLVSKRALGAISNASK 504

Mouse    97 PPAYSVHVLSSLLPGARGPALLPLSAGVRVIPVEIKEAGGSVPGGSPEDAAFQAPLAQESCCKFP 161
            |.:.:   .||..|.|...  ||....:..:.|::|:: .|| .....|::...|.|::......
  Fly   505 PASAA---SSSATPSASQE--LPRKHRLTDLNVQLKQS-ASV-SSEASDSSDAGPEAKKPRYVIT 562

Mouse   162 SSQEAEEASSCPRKK--------------DSSPMVICQLK-----------GGAQMLC------- 194
            ..|.:::|:|.|.:|              .:||......|           |...|:|
  Fly   563 MQQGSQKAASQPVQKLINRTANVQRVVSSSTSPSSNSTKKIYNYVQPTGSNGAKYMICNSGVPQS 627

Mouse   195 ------------IDNCGAR----------------ELKALHLLPQYDDQSSFPQSELPKPMTTLV 231
                        ::|...|                :.::.|...|...:....|.:||...:|
  Fly   628 STSAMRRGYTGYVENKTRRPPPISPQQHRFKQMGPQQQSKHQQLQAQAKQRIRQQQLPTEQST-- 690

Mouse   232 GRLLPVPAKLNLITQVDNGALPSAV--NGAAFPSGPALQGPPKITLSG----------------- 277
                |:..:..|.|      ||..|  |..|.|....|:.|.....:|
  Fly   691 ----PIKVEPKLPT------LPPGVKANVPAKPLFEVLKPPATAAAAGAVDPLGGMTSRRKHCNC 745

Mouse   278 --------YCDCFSSGDFCNSCSC----NNLRHELERFKAIKACLDRNPEAFQPKMGKGRLGAAK 330
                    |||||::|:||..|:|    |||.:|:||.:||::||||||.||:||:.....|..:
  Fly   746 SKSQCLKLYCDCFANGEFCQDCTCKDCFNNLDYEVERERAIRSCLDRNPSAFKPKITAPNSGDMR 810

Mouse   331 LRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIACKNYEESPERKMLMSTPHYMEPGDFESSH 395
            | |:||||||||||||||||||||||.|||||||:.|:|.|:.|:             .|.:|..
  Fly   811 L-HNKGCNCKRSGCLKNYCECYEAKIPCSSICKCVGCRNMEDRPD-------------VDMDSLD 861

Mouse   396 YLSPAKFSGPPKLRKNRQ-----AFSCISWEVVEATCACLLAQGEEAEQEHCSPSLAEQMILEEF 455
            .|...:.....| .||:|     |....:.:|:|||..|::::....|:::.:....|:.::||.
  Fly   862 GLMGVEGQKKDK-AKNKQLNENRANIYFTDDVIEATIMCMISRIVMHEKQNVAVEDMEREVMEEM 925

Mouse   456 GRCLSQIL 463
            |..|:||:
  Fly   926 GESLTQII 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tesmin	NP_001034746.1	TCR	334..371	CDD:281618	31/36 (86%)
mip120	NP_001163143.1	TCR	740..775	CDD:281618	10/34 (29%)
mip120	NP_001163143.1	TCR	813..850	CDD:281618	31/36 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846075
Domainoid	1	1.000	82	1.000	Domainoid score	I8412
eggNOG	1	0.900	-	-		E1_KOG1171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12446
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2613
SonicParanoid	1	1.000	-	-		X1765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830