Protein Alignment DNASE2 and DNaseII

DIOPT Version :10

• Sequence 1: NP_001366.1
• Gene: DNASE2 / 1777
• HGNCID: 2960
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_650672.1
• Gene: DNaseII / 48228
• FlyBaseID: FBgn0000477
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 349
• Identity: 116/349 - (33%)
• Similarity: 173/349 - (49%)
• Gaps: 27/349 - (7%)

Human    17 LTCYGDSGQPVDWFVVYKLPALRGSGEAAQ--RGLQYKYL-DESSGGWRDGRALINSPEGAVGRS 78
            ::|..::|..|||:.:||||......:..:  .||:|.|: .::...|:.....|:.|.....::
  Fly    23 VSCKDEAGNDVDWWHLYKLPKHYQHNDLGKDTSGLKYLYVTSQNYDTWQMSGKFISDPLSLPAQT 87

Human    79 LQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAA 143
            |.|| ..:.|......||||  ||:....|| .||.|||:..|.:...|:|||||.||   :...
  Fly    88 LNPL-NDDPSHTLLAAYNDQ--QPNGTVFSS-GGHAKGVVASDGETAIWIVHSVPKFP---TIPD 145

Human   144 YSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQE---FPDLENVVKGHH 205
            ||:|.|...|.|::|||:.......|:|:.|.|..|..| ||...:..:.   ||.||..:.|..
  Fly   146 YSYPTSGEQYAQSMLCVTLKGEDLEKVGQILVYNEPHFY-YQRNPLATRSDELFPSLERALHGQW 209

Human   206 VSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDI 270
            .::.|:...:.:.|..|..|:.|.|..:...:||:..:|..|..:|.|:.|....|.||::|...
  Fly   210 RTESPFQKDLEVRSLDGKKFRLFGKSGRANVELYADVVAPTLDVSLFVEAWRDGAGNLPNSCDKS 274

Human   271 WQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSPK------------GPWTCVGDMNRNQGEEQRGG 323
            .:||||..|:.| .....|.:|:|||||.||..            |.|.||||:||.:|:..|||
  Fly   275 DKVLNVESISNP-ELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGG 338

Human   324 GTLCAQLPALWKAFQPLVKNYQPC 347
            ||:|.:...:...::.||.||..|
  Fly   339 GTVCHKSARVSNLYRQLVTNYDKC 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNASE2	NP_001366.1	DNase_II	18..336	CDD:460868	111/335 (33%)
DNaseII	NP_650672.1	DNase_II	24..351	CDD:460868	111/335 (33%)