DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D2096.11 and Msp300

DIOPT Version :9

Sequence 1:	NP_001379846.1	Gene:	D2096.11 / 177638	WormBaseID:	WBGene00017078	Length:	727	Species:	Caenorhabditis elegans
Sequence 2:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	169/840 - (20%)
Similarity:	294/840 - (35%)	Gaps:	230/840 - (27%)

- Green bases have known domain annotations that are detailed below.

Worm    25 HIFEALAVISKDEALQESPSLLLVSKQVSKKIEQLKVLLKLVEEKKDTFISKCKLVMRTAGPESD 89
            |:..|..|..||.:...:.:.::   .|...:|.:..:..|....|.|.|...:.|...|.|.:.
  Fly 10235 HVPTADVVEPKDSSPTSTTAAVV---DVEAVVEDINEIWPLEHHLKPTNIDFSQHVEELAAPAAV 10296

Worm    90 AKELDSLMKHVEDAYSD-------------VFELISDKEGLIDRFNASNINSDSVPNTESLNLAF 141
            ..|.::.|. ||:.:..             .||..|..|        .:..||.|...|:.....
  Fly 10297 TAETEASMP-VEEIWPTSPETGNSLTLEQYEFEPQSPHE--------ESTKSDLVKPQETEPQVV 10352

Worm   142 AAADPE-FGAGRLLDAEDVDTNNNPDEKPVITYVSSLNNAPQDPEMSRLAASGGKGFEEEIGKLQ 205
            |...|| ...|.:...:...|..:..|.|..|.|   .|.|.|.:            :....|::
  Fly 10353 AETKPEGITTGSITITKTTTTITSSTEVPEETLV---QNVPADEQ------------QPPANKIK 10402

Worm   206 ADADHIFEA---LAVMSKD-----------EALQESP-SLLLYSKQIRFNKIQKLKELLKP--VE 253
            .|.....||   ||...|:           |.:|..| .::|..:.:..:.|:..:...:|  ||
  Fly 10403 TDIQSFLEAEQTLAAALKEQSSTPTGASVAEDVQTQPEEIVLEERTVEISTIKTEENQQEPVIVE 10467

Worm   254 EKKDTFISECKLVMKTAGPEADTKELD----SLLKQVEDAYSDVFELISDKE---GLIDRCNASN 311
            |.|...:.          ||....||:    ::::|.|:...   |.:.:|:   |.||...|:.
  Fly 10468 EVKSLPVE----------PEPVEPELEEVAIAIVEQTEEKPE---EPVIEKQPASGPIDLRAATQ 10519

Worm   312 --INSDSVSNT-ERLNIALAAADAE-FGAGRLLDAEDVDTNNNPDEKSIITYVSSLNNAFPLEPE 372
              |:.::.::| .:....::|...| .|||.|......::.|..|..:..|...|:...     |
  Fly 10520 LFISGEAAASTAPQKTFQISAPSLEDNGAGVLKVVLGKESTNEEDTAAPTTGKVSMTII-----E 10579

Worm   373 MSKYVASGGKRLEEEIGKLQADADHIFKALEEISKDEALQESPSLLLDSKQVSKKIEQLKVLLKP 437
            .:...|:..||..::  |.:.|..|    .||:.:::..:..|...:...:||..:.     :.|
  Fly 10580 TAAAPAADAKRRRKK--KKRRDTKH----EEELEQEQETEPEPVAAVKEPEVSSDVP-----VSP 10633

Worm   438 VEEKKDTFISESKLVMKTVGPESDAK--ELDSLMKHVEDAY------------------SDVVE- 481
            .:..:||...||   :..:.|:||..  |:|:.:|.||||.                  ::|||
  Fly 10634 EDSPRDTVRHES---IVEISPDSDLSSIEIDTKVKIVEDAVVSSPSESPRTPMVELVIPTEVVEL 10695

Worm   482 -LISDKEGLIDRCNASNRIAHPQTETEKITNEIE----------LLKETCSCCTPYQIE------ 529
             |:.|:|.     ..:.||..| ||..::..:|:          .|.|| :..|..:::
  Fly 10696 ALVEDEEQ-----QTTPRIPSP-TEKSEVEQDIKSVQTSPQHQPKLDET-AVQTSLEVQPDNQEN 10753

Worm   530 -------KISENYYRFGDTHIKRMVRILRSTVMVRVGGGWEP---------------LEESLQ-- 570
                   :|:|...:......::.|.:..||..::.....:|               :|:.||
  Fly 10754 ESQTLIVEITETEAQTTPRSEEQSVAVEISTTEIQTDVSGQPAETVEISSQTTVTTTIEKELQTT 10818

Worm   571 -KHDPCRTKGRLNINMFPEARPIHALD-LMQSFTKNRHAKQMPI-AGTPGPIMKIREKTERSVPM 632
             |..|          ..|||.....:: |:|...|:. ...:|: ......:.:....||..|
  Fly 10819 PKDSP----------RAPEAGSSDVVESLVQDLVKDM-TTDLPVRTSEQSTVTETTTTTETHV-- 10870

Worm   633 SGGLGGTAGYTVTTESPRKTPQRPFRIPRTPSDKT-----------------PGRQSRVGC-VSN 679
                      ..||..||:  |.....|.|..::|                 ||.|..... .|:
  Fly 10871 ----------QTTTPEPRE--QTEVIKPETAHEETSTVELVQFADGEMQTTPPGDQQPASLDDSS 10923

Worm   680 LKNSIVEPSSPSQSE-------------SRASPEVADRQKRVSLSLKE-KGKRFKKNAER 725
            |..:.:..|.|.:.|             |.|.|.|.:..:.:.|..:| |.|:.||..::
  Fly 10924 LTATSISVSEPYELEVKTTVAIPADSDTSVAEPTVYEYTQTMQLPKQEKKSKKDKKKKQK 10983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D2096.11	NP_001379846.1	CH_SF	<117..180	CDD:412120	13/63 (21%)
		CH_SF	<315..368	CDD:412120	11/54 (20%)
		GAS2	507..579	CDD:128539	16/112 (14%)
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910