Protein Alignment hlh-30 and Mitf

DIOPT Version :9

• Sequence 1: NP_001023411.1
• Gene: hlh-30 / 177157
• WormBaseID: WBGene00020930
• Length: 524
• Species: Caenorhabditis elegans
• Sequence 2: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 139/608 - (22%)
• Similarity: 212/608 - (34%)
• Gaps: 201/608 - (33%)

 Worm    28 QQQQQPQQAQQQFYDD--EPYQANASQFRFGAGKSMEQRR--ETGNLIPIAQRSMGSTSTPFGSA 88
            ::|||....|||..|.  :|    .....||:|:.:.:..  ::|:   .:....||:|....|.
  Fly   188 REQQQQMMIQQQTLDTAMDP----KMHLLFGSGQGLMESEFIDSGS---TSACGSGSSSLEQMSQ 245

 Worm    89 PTQ-SYFGGGSSGAALSSP-----------------------------RKMQQTHQMLFGNIQPP 123
            ..| ......||||.|..|                             ::..|..|.|..:.:|.
  Fly   246 LVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPS 310

 Worm   124 R-GSPPS------------------------DGSDKIHRFG-------------ESPTP-GGVGG 149
            . ||..|                        |..::.:|||             :...| ...||
  Fly   311 MWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGG 375

 Worm   150 VFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARP----IPGASSRAGSGHSGSPI 210
            .| ...||:           ..:.|...||.:.|..:..:..|.    :..|:|...|..|.|.|
  Fly   376 SF-VRCDDI-----------NPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGI 428

 Worm   211 TIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYY---------------- 259
            .....:|:....:.|:|||.|. .:..:..:||          :|:|.:
  Fly   429 VNSIRISSTSSSLQSTSAPISP-SVSSVATSVS----------EPDDIFDDILQNDSFNFDKNFN 482

 Worm   260 ---------------------RDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTS------ED 297
                                 :||:|||.|||||||||:||||||||||.:|||.:.      .|
  Fly   483 SELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRD 547

 Worm   298 MKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSH 362
            ::.|||||||:|.|||:.|:.:..:..:.:.:|:.:|....|...|:||||......|:.:..:|
  Fly   548 IRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENH 612

 Worm   363 LPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAP 427
            |..:                  ..||..::.|...              ||..||....:.:...
  Fly   613 LTSL------------------SAPTQPYLKSFSL--------------SPTASRSRRSLFDQPV 645

 Worm   428 SDSFFSVGSASPPDYRTSSGTASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQ 492
            ......:..|        .|..     |.|...:.|.|....:..|||::||     ..|..|:.
  Fly   646 EKKIQVIDGA--------DGNM-----GMNQVDEFMEDCKYAVQGGDPMLSS-----HSHMQSAP 692

 Worm   493 MSPDIHWDASGFSPDPINTQQSN 515
            .||......|| |.:|.|..:::
  Fly   693 QSPSSKTLNSG-SFEPKNFSEAD 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hlh-30	NP_001023411.1	bHLHzip_MITF_like	260..328	CDD:381403	40/73 (55%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	4/38 (11%)
		HLH	505..570	CDD:238036	40/64 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159723
Domainoid	1	1.000	73	1.000	Domainoid score	I6057
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		oto17593
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45776
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070