DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lad-2 and Nrg

DIOPT Version :9

Sequence 1:	NP_001023496.1	Gene:	lad-2 / 177078	WormBaseID:	WBGene00002243	Length:	1187	Species:	Caenorhabditis elegans
Sequence 2:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	1227	Identity:	389/1227 - (31%)
Similarity:	594/1227 - (48%)	Gaps:	94/1227 - (7%)

- Green bases have known domain annotations that are detailed below.

Worm     9 LLITQVFAAQKNSIG--PPKLLEQ--SGEEVWYHLDDEDLLKNRLTLRCEADENTD-RYSWLKDG 68
            ||:..:.|....|.|  ||::.:|  .||.::..........|...:.||||...: .|||:|:|
  Fly    11 LLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNG 75

Worm    69 EPFVIDSEDVLWEKESQSGSIVFTKPHASHQGYYQCFASNIFGTALSNKMHLRLGSLEHFPKRDV 133
            :.|...:.|....::...|::|.|.|....:|:|||||||.||||.||.:::|...|..|.....
  Fly    76 KKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAA 140

Worm   134 KLLRVKEGESLTLNCTPPRGTPDPKIVWLYRSLDDSSVIETIRSRHITVDNEGHLHFSSVELSDG 198
            |.|...|||...|.|..|.|.|.|.:.|:.:...|.| |::|.:..:|:|.||:|.||:|...|.
  Fly   141 KTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGS-IKSINNSRMTLDPEGNLWFSNVTREDA 204

Worm   199 KATLVYECAATSPVLRGEYRSGDRIQLDIE-----PSQDKSHPVKKMSVSPSEVTVRAGGQLKLQ 258
            .:...|.|:||| |.|.||:.|:::.||::     .||:| ||..:..||..:.....|.:::|.
  Fly   205 SSDFYYACSATS-VFRSEYKIGNKVLLDVKQMGVSASQNK-HPPVRQYVSRRQSLALRGKRMELF 267

Worm   259 CIFGGRPLPTIFWSKIDGELPKSRIK--DLTSHESDFGRSLIVENVHPDDAGAYECR-----GRH 316
            ||:||.|||...||| ||:    ||:  |..: :..:|:||::...:.||||.|.|.     |..
  Fly   268 CIYGGTPLPQTVWSK-DGQ----RIQWSDRIT-QGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNA 326

Worm   317 LVHTVNVRVMAAPFWEFDPPRDISLPEESTGELECLAGGQPTPIITWSMNGKFLHELAEDSRRVL 381
            ...::.:.|.:.|::..:|....:..:|.. ..||.|.|.|.|.|:|..|||.:.:...:.||.:
  Fly   327 QSFSIILNVNSVPYFTKEPEIATAAEDEEV-VFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTV 390

Worm   382 LDHGRILRVRNLNHDLDTGVYQCNASNPLGYVFANAFVHVRAHAP-FFRMPAARHWKVVLHSTVV 445
            .|:  .:|:.||... |||.|.|||:|.||||:.:.:::|:|..| ....|||  ...|....|.
  Fly   391 TDN--TIRIINLVKG-DTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAA--VSTVDGRNVT 450

Worm   446 LDCDVDAAPEAMVRWVDADDRPLQVVEGKNKLFPNHTFMVYDVNSADEGLYYCNVSNKYGINRAT 510
            :.|.|:.:|:.:|:|:.|.:   .:..|:..:..|....:.||..:|.|.|.|...||:|..:|.
  Fly   451 IKCRVNGSPKPLVKWLRASN---WLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQAD 512

Worm   511 NRLQVFKPTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGKVL---TESQYYEIL 572
            ..|.|.:.|...:  .|:...:.||::|...|....|..|.|...|..:|:.:   .:.::.:..
  Fly   513 GSLVVKEHTRITQ--EPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTN 575

Worm   573 PDRLRFRSVRGRHSGIIDCAAITDVDVKLASMQLIVKDVPAHPVVETAHCSERKATVKWVAASDH 637
            .:.|.........||...|.|.|.:|...|...|||:|||..|.:....|...||.:.|....|:
  Fly   576 DNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDN 640

Worm   638 GDSIKKYIVEMFTDFKKNEWEVINEEVNVNKETFEVDITLTPWVNYTFRVVAVNSHGRSDMKIDG 702
            ...|..|.::..|.|....|:...|:|.....:|.|.  ::||.||||||:|.|..|.|
  Fly   641 RSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQ--MSPWANYTFRVIAFNKIGAS------ 697

Worm   703 QPKEDWLTCQTRPSFPYTNPTGVKGEGTEPDNLVISWKPLDRYYWNAPNMQYLVRYKLDEPIHGW 767
            .|.....:|.|:|..|:.||..|.|:||||:||||||.|:.....||||..|.|.:|.|.|...|
  Fly   698 PPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAW 762

Worm   768 TEFLVEDSLANFTIIRDQPTFRKYLIQVQSVNSVGPSIVEPEIHHGWSGEDVPDEAPRDFHIDTQ 832
            ....:.|...|..:|.|||||.||||:|.::|..|.|.|..|...|:||||.|.:||.:|.: .|
  Fly   763 ENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTM-RQ 826

Worm   833 INFTTINF-TWNPVDANTVNGHFVGYEIEYW---KAENTIRKYSIKIPANSTYKVINSFHAVTNY 893
            |..:|..: .|.||...:|.|||.||:|:.|   :.|..:|:..:|  .::...::..|...:..
  Fly   827 ITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVK--GDTHNALVTQFKPDSKN 889

Worm   894 SAHIRTRNKRLRSAPSDYVSFAMPEGPPGKVHNLRVYSVGSTAILLQWDAPLQPNGRIRGYFISF 958
            .|.|...|.|....||..:.|..|||.|..|..|..|.:||:|.:|.|..||.|||::.||.|.:
  Fly   890 YARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYY 954

Worm   959 QNEKNETEETYVIHRQKHYLHEKS-----------EPDTGYKVSVWAETRAGEG------PVTLR 1006
            :    |.:|:||..|:::..|...           :|::.|::|:.|.|:.|||      ..||:
  Fly   955 E----EVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLK 1015

Worm  1007 -PVRTWPARIPDAPIFRVKNISLDS----FVVEWQPNNHSVWKMPGAAFFVNYTAESSKTWF-QS 1065
             .|...||    .|.|..:.:..|:    |.:.|.|:...   .||..||..:..:....|. ::
  Fly  1016 DAVNVAPA----TPSFSWEQLPSDNGLAKFRINWLPSTEG---HPGTHFFTMHRIKGETQWIREN 1073

Worm  1066 EIIYLPYTEITIRNLKEDQKYFMQGIAKDGPRRSESVFLPIKTLNRDYANRLKEDSLRSAAWFIA 1130
            |.....|.|  :..|..:..|..:.::.||...:||....|.|...:....:..:::.:|.|||.
  Fly  1074 EEKNSDYQE--VGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANAGWFIG 1136

Worm  1131 VLGVLGIGLFTICLTFCCGNKNRQEKFAVRRKEIEIGHQQDNEEEKQFLEYQYGFKN 1187
            ::..|.. :..:.:..|...:||..|:.|..:|:..| ::|..||..|.||.....|
  Fly  1137 MMLALAF-IIILFIIICIIRRNRGGKYDVHDRELANG-RRDYPEEGGFHEYSQPLDN 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lad-2	NP_001023496.1	IG_like	48..116	CDD:214653	27/68 (40%)
		Ig	49..121	CDD:299845	29/72 (40%)
		Ig	124..214	CDD:299845	33/89 (37%)
		IG_like	244..325	CDD:214653	27/87 (31%)
		Ig	255..325	CDD:299845	26/76 (34%)
		I-set	335..421	CDD:254352	31/85 (36%)
		Ig4_L1-NrCAM_like	344..422	CDD:143179	30/77 (39%)
		IG_like	438..515	CDD:214653	21/76 (28%)
		Ig	443..516	CDD:299845	20/72 (28%)
		IG_like	527..608	CDD:214653	19/83 (23%)
		Ig	535..>593	CDD:299845	12/60 (20%)
		FN3	610..697	CDD:238020	29/86 (34%)
		FN3	721..804	CDD:238020	40/82 (49%)
		fn3	823..909	CDD:278470	25/89 (28%)
		FN3	921..1010	CDD:238020	34/106 (32%)
		FN3	1016..1108	CDD:238020	21/96 (22%)
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	29/72 (40%)
		IG_like	57..127	CDD:214653	29/69 (42%)
		Ig	135..214	CDD:299845	28/79 (35%)
		IG_like	141..216	CDD:214653	28/75 (37%)
		ig	251..332	CDD:278476	29/86 (34%)
		I-set	339..427	CDD:254352	32/91 (35%)
		Ig	354..427	CDD:299845	30/76 (39%)
		I-set	432..517	CDD:254352	25/89 (28%)
		Ig	446..517	CDD:299845	20/73 (27%)
		I-set	522..611	CDD:254352	19/90 (21%)
		ig	525..609	CDD:278476	18/85 (21%)
		FN3	613..707	CDD:238020	31/101 (31%)
		FN3	716..807	CDD:238020	43/90 (48%)
		fn3	817..905	CDD:278470	25/90 (28%)
		FN3	917..1004	CDD:238020	29/90 (32%)
		FN3	1041..1111	CDD:238020	17/74 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I4170
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21041
Inparanoid	1	1.050	550	1.000	Inparanoid score	I619
Isobase	1	0.950	-	1	Normalized mean entropy	S6160
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		oto17288
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	1	1.100	-	-	LDO	PTHR12231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16902
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.960