DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mstn and scw

DIOPT Version :9

Sequence 1:NP_034964.1 Gene:Mstn / 17700 MGIID:95691 Length:376 Species:Mus musculus
Sequence 2:NP_001286088.1 Gene:scw / 46000 FlyBaseID:FBgn0005590 Length:400 Species:Drosophila melanogaster


Alignment Length:361 Identity:90/361 - (24%)
Similarity:130/361 - (36%) Gaps:74/361 - (20%)


- Green bases have known domain annotations that are detailed below.


Mouse    63 SKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESD 127
            ||..||....||:|        ..|...|..::....||....|.||....|:..:|:|..:.. 
  Fly    65 SKFLLEVYNEISED--------QEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRL- 120

Mouse   128 FLMQADGKPKCCFFKFSSKIQYN--------KVVKAQLWIYLRP--VKTPTTVFVQILRLIKPMK 182
                   ||:....:....|.:|        .:|:|.|.||.:|  |.......|.:.|.:...:
  Fly   121 -------KPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQ 178

Mouse   183 DGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLK----QPESNLGIEIKALDENGHDLAVTF- 242
            |.: |..:.|:....|...  |...::...|:.||.    |..:.|.|.|      |.....|| 
  Fly   179 DFS-YRILGSVNTTSSQRG--WLEFNLTDTLRYWLHNKGLQRRNELRISI------GDSQLSTFA 234

Mouse   243 -----PGPGEDGLNPFL-------EVKVTDTPKRSRRDFGL--------------DCDEHSTESR 281
                 |......|.||:       |:.|.....|.:||...              ..|.:.....
  Fly   235 AGLVTPQASRTSLEPFIVGY
FNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQS 299

Mouse   282 CCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGP 339
            |.|...|||| |....:|:||||:::|.:|.|.|.|....|...|:      |:|...|. ...|
  Fly   300 CERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPH-LPKP 363

Mouse   340 CCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 375
            ||.||.:..|.:|.:..::.|...|....|...|||
  Fly   364 CCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MstnNP_034964.1 TGFb_propeptide 37..250 CDD:366248 46/206 (22%)
TGF_beta_GDF8 269..376 CDD:381658 36/128 (28%)
scwNP_001286088.1 TGFb_propeptide 39..254 CDD:279078 49/213 (23%)
TGFB 300..400 CDD:214556 35/101 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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