DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGER and igcm-1

DIOPT Version :9

Sequence 1:	NP_001193858.1	Gene:	AGER / 177	HGNCID:	320	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	88/381 - (23%)
Similarity:	141/381 - (37%)	Gaps:	87/381 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    23 AQNITAR----IGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 83
            ||.::||    :||.:.|.|:.         |...|...:..|  .||..||.:......  ..|
Worm   428 AQIVSARQNVDVGETIKLMCQA---------EDAGNPSASYTW--ASPSSGGIFGLEGHT--EKS 479

Human    84 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS-ASE--LTAGVPNKVVEES 145
            ..:....:.|.|::.|:|.|..|:.......:.|.:   |..|... |:|  .|:|...|::|
Worm   480 FEVRNAQLSDNGVYSCKAYNDLGEGKIGTVMITVIE---KARISSPLATERIFTSGEQGKILE-- 539

Human   146 RRSRKRPCEQEVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLF---TLQSE 207
                          |.::| ||:..:.|..||:|:..:....|...:::..||.  |   |:.|.
Worm   540 --------------CEAQG-YPSPVIKWLKDGRPVKQSIYASSATSESKCLPED--FCTQTVAST 587

Human   208 L-MVTPARGGDPRPTFSCSFSPGLPR-HRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAP--G 268
            | :..|.:..| :..|:|....|..: .:...:..|...:.:||.|..    ..||....|.  |
Worm   588 LTLAGPLKWSD-KGNFTCVADNGSDKTDKDSSSWTIVRVLHKPVFLNR----KFPEKSLAAADIG 647

Human   269 GTVTLTCEVPAQPSPQIHWM-KD--------------GVP-LPLPPSPVLILPEIGPQDQGTYSC 317
            ....:.|:|.|:|.|:.||| :|              |:. .|.....:|.:..:...|.|.|.|
Worm   648 SQAIIRCKVSARPEPEFHWMFRDSEISENERHSFHTVGITGKPDEYEQLLQIESVQESDYGEYVC 712

Human   318 VATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALL 373
            .||:.:.|..       .:||..:..|.|          |.|.|..|.....:.||
Worm   713 RATNGNGGDH-------VVIELRKTSPPA----------LPLDLQKLSATSNSVLL 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGER	NP_001193858.1	IG_like	24..117	CDD:214653	21/96 (22%)
		C2-set_2	124..235	CDD:369750	27/118 (23%)
		Ig_3	257..320	CDD:372822	20/80 (25%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845
		Ig	146..226	CDD:299845
		Ig_3	245..316	CDD:290638
		IG_like	258..329	CDD:214653
		IG_like	338..398	CDD:214653
		IGc2	347..398	CDD:197706
		Ig_2	429..513	CDD:290606	21/96 (22%)
		IG_like	437..513	CDD:214653	18/88 (20%)
		Ig	537..615	CDD:143165	21/97 (22%)
		IG_like	644..728	CDD:214653	22/90 (24%)
		IGc2	646..719	CDD:197706	19/72 (26%)
		FN3	733..843	CDD:238020	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910