DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kvs-5 and Shawl

DIOPT Version :9

Sequence 1:	NP_001294321.1	Gene:	kvs-5 / 176899	WormBaseID:	WBGene00021948	Length:	600	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	138/516 - (26%)
Similarity:	225/516 - (43%)	Gaps:	103/516 - (19%)

- Green bases have known domain annotations that are detailed below.

Worm   141 LNIGGSSYRIRTRSIIKFGPKTLLGRFVRMNHEHRRQWADWYFEEQDEYFFERVPRYFDPIYDFY 205
            ||:.|..|.....::.|. |.|.|.|.......        |....:||||:|.|..|..|.::|
  Fly     9 LNVSGIRYETYKATLKKI-PATRLSRLTEALAN--------YDPVLNEYFFDRHPGVFTQILNYY 64

Worm   206 ATGKLHVPKDLCFDKFMAELRFWAVSKSRMDECCSPFTQYCVTMGGDPKCT---DEAAELQKEKD 267
            .|||||.|.|:|...|..||.||.:..::::.||  ::.|.:..  |.:.|   .:..:::.||.
  Fly    65 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCC--WSTYSIHR--DTQNTLAILDKLDIENEKP 125

Worm   268 ------HFIG---------VRC-ANIRRRLWLILEGHSQSKWWKAFEIISTAFVVLSISALILGS 316
                  ...|         :.| ..|:.::|.:.:..|.|...|....:|..|:.:|:.:..|.:
  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190

Worm   317 IPEFQV---------------------------PQKSE---------DGQL--VYATATYPTYPN 343
            .|.|:|                           ||..:         .|.:  .:....|.:|.:
  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255

Worm   344 G----GGMTIESRTVVREGSD------NSTGDLM---AEETV---PTPRNTGKIEM--TEHPVFT 390
            |    .|......|:  :|..      |..|.::   .||.:   ...|..|.||.  ..|..|.
  Fly   256 GNFTASGQATPIATI--KGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318

Worm   391 WVENVCVIYFSIEYAMRFIVAPRKLAFARQILNVIDLLSIAPFYFELLLWICGISGENVRKVRWA 455
            :||.||.::|.||..:|.||:|....|.:..:|:||..:...||.:::..:...:|
  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTG--------- 374

Worm   456 FLTVRLLRVLRVIRIAKLGRFSPGLANFALTIRKSKKQMQMVGVVMMTVIIFFSTLIYFLER--D 518
              .:....::|::|:.||.|.||||.....|.:.|.|::.::...::..|:||::|.|:.|:  |
  Fly   375 --LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQD 437

Worm   519 EPGTKFTSIPATFWWCVVTMATVGYGDLVPVTVAGKLVGSGAIVCGVMVLALPITIMVNNF 579
            .|..:|.|||...||.:|||.||||||:.|.|..|..||:...:.||:.:|||:.::|:||
  Fly   438 NPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNF 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kvs-5	NP_001294321.1	BTB_POZ_Kv	139..228	CDD:349626	30/86 (35%)
kvs-5	NP_001294321.1	Ion_trans	377..587	CDD:366146	71/207 (34%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	34/100 (34%)
		BTB_2	7..97	CDD:280393	32/96 (33%)
		Ion_trans	307..506	CDD:278921	70/203 (34%)
		Ion_trans_2	<449..499	CDD:285168	24/50 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920