Protein Alignment Y75B8A.24 and Pi4KIIIalpha

DIOPT Version :9

• Sequence 1: NP_499596.2
• Gene: Y75B8A.24 / 176653
• WormBaseID: WBGene00013557
• Length: 2106
• Species: Caenorhabditis elegans
• Sequence 2: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Alignment Length: 2258
• Identity: 807/2258 - (35%)
• Similarity: 1225/2258 - (54%)
• Gaps: 285/2258 - (12%)

 Worm    14 CLAICIAQNENTKLSQIFNLLALDDKEEQFEAQPLSHNVRCSLIAIANYLLHSHGQHADELVPML 78
            |||..:|..:.|...::..|.....:|.......|....:.::||:..|.|....||..::||.|
  Fly    17 CLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEGQIVPYL 81

 Worm    79 LRALIALPHMKWIDDGLLNKSD--KIPIQEQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACA 141
            ||....||...||||...||.:  :||..|:||||.||.|||:||..|..|::|:..|.:.|: |
  Fly    82 LRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQVETLS-A 145

 Worm   142 VSSIYDVLEDQESLEHNYSHVIKLMCYA-----LGLLRSIGRFSADYDTPLISLIFP---LPVDE 198
            :::|.....|..|.....     ::|.|     .||.||:||:::: |.||:..|||   ||:.
  Fly   146 LANIVKSSRDSSSAPPPI-----ILCKATVPLLFGLARSMGRYASN-DPPLLCRIFPPELLPIQ- 203

 Worm   199 TKKCKGAGGADIKHRISSDEFTFDTSCDASSSDPLLLTD--------SKSSRLIRMYN------- 248
                || ||.|.....||...|...|  .|||:.|..|.        |.|..|.:..|
  Fly   204 ----KG-GGRDGTGSSSSASGTCGGS--FSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGR 261

 Worm   249 -----------------------------KLGASFLLNNYTGGLKLTMSS--------------- 269
                                         :.|:||   |....:::..|.
  Fly   262 QRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSSF---NQFPNMRVCESPTKGGPRPLYRVPPFP 323

 Worm   270 -EDLEKLFDSVQRLMDSKFLESLDEISGEIFSGGSGVKRNPYKSMSEITNLCCLTLLKDVLGPYS 333
             :.|:.:|...::|:....||.|||.:.:|||... :|...|||.||..||..:|||:::|
  Fly   324 IQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQ-IKGYCYKSFSETLNLVLVTLLRELL---- 383

 Worm   334 VKNSDKNQENCGNSLQEASPSSPISEKFAKEISIFSKTALSKLDAELSSLQHSSESSLSTE---- 394
                 ::|.:             :...|.|::..|.|........||.:.|...|.....|
  Fly   384 -----QHQVD-------------LPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIA 430

 Worm   395 -VSRQKLNIQSATVCLQLIAWAAID---DMD-----------------ADAICTEIIVRLFANQT 438
             |::.|:|:.:...|:.|:.||..|   |:|                 ||.:|..:..:|....:
  Fly   431 VVNKYKVNVMANAACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELS 495

 Worm   439 QKTIISQLPLYLKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAPMLTKLASDS--TLERGKSA 501
            .|.::..:||.:..:..:..||.|||.:|.|: |..|:.||:.|:|:|.||...:  :|.:.|..
  Fly   496 HKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTS-ISYLRDFLVAPSPILGKLHDHAMQSLAQQKKE 559

 Worm   502 GDV------IQHSKSSNNLIDAITKRK-----------LSLDALRNSAIKAICRALKSSIRMESD 549
            .::      :|||.|...::.....:|           .:.::||::||:.:..||:::..::..
  Fly   560 KELTPFKIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQF 624

 Worm   550 SVQQCLAGLSTKLFV-----------CSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVEVPEMV 603
            .|...:|.:|.:||.           |..:|     ||..|.|..||.:.|.|.|::  :..:.:
  Fly   625 CVPALVANVSNRLFTAEKSGSESQGECHKSN-----LVSLNIIVMLGHVAVALKDTS--KTTQNI 682

 Worm   604 VQIYLQRFANPPSQLDVTMIRCLAEMWIAGARS-IYENVWKLFTQICIESSNRVYSQGNNESNDQ 667
            :|.::|||...||:.:..::..|..|.|:...: :::.:.|:|:::.::|::..|:  ::..:.:
  Fly   683 LQFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYT--SDPEHRK 745

 Worm   668 RYTHVSLAVDVAMSRMAAGVANEDDKMTLLVRLLELFVQLGIEGRRVGEKVSKSTVKMSTSAGNL 732
            ::.|||.||..|:..:||.:..:.:.:.||.:|||||||:|::|.|..:. :....|.|:.||||
  Fly   746 QFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDN-TPGAQKASSRAGNL 809

 Worm   733 GVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCTVLGFDVESSSLWPEEWYNAVCETATKTPV 797
            |:|:|.||.|:||:.||..|..:|..||:|||.||.|:||  .::.|||.:||..|.:.|.|:|:
  Fly   810 GMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMGF--TNARLWPADWYQGVQQIAAKSPL 872

 Worm   798 LIATENLRS---ELIDNAAIRSDSISPQELQEMRNTVLAELSHQAEAV-PLINRFDFANCTYLLS 858
            ||:....:|   ||....||:|||::     |:|:.:|..|.|.::.| ..||:..||.||||||
  Fly   873 LISQTAHKSDMRELNYTLAIKSDSVN-----ELRSQILVLLEHSSDNVATAINKLSFAQCTYLLS 932

 Worm   859 VHRMETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWTCMLAAAPRIFLEWCEKMMKRRDNDEP 923
            |:.:|.:|:.:|:. .:......|:.|..:::||:|:|.|:...|.::|.::...:..   :||.
  Fly   933 VYWLEMLRVENADE-PSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYA---HDEI 993

 Worm   924 TEEALVWHAQFLLFKFNHHLREVRKVADACLSQLVKAFPYLLWNTKVLTTILRLLQELEDNLQKD 988
            .|:.|...|..||..|||..:.::.|||..||.||..||:||||.:||..:|.:||.|..:|..|
  Fly   994 REKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLD 1058

 Worm   989 PTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFSMRVKQILKEALRWAPASTHSNLLEYVSKFG 1053
            |....|...:.. ..:|:||.||:..|...:|||:.|.:.|:.||::|||.||.|:|.||.::..
  Fly  1059 PNEETPTLRVVS-TPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIP 1122

 Worm  1054 S---ERDAAMQLAIDATSEGSGK-SGS--------------YLTSLYKRSNYLGQVKGMLATTLS 1100
            :   ...:.:.||.|:....|.: :|:              :::.|..||.|.|::.|:|:....
  Fly  1123 TPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSE 1187

 Worm  1101 GDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLNERILSLLVRTPLLNF 1165
            .|      :..|.|||..|...||....|.....|:...||..:....::.::|..:..:.|..|
  Fly  1188 KD------KAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELF 1246

 Worm  1166 TESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGLFEKEVVGGSPL-----CQKLE 1225
            |||.:......|.|:|:||.:....|:.|...|:..:....:|||..|.....||     |:.:.
  Fly  1247 TESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVS 1311

 Worm  1226 RPPPSANFRPHREWIEFIGERCDVASYSSREQLDVLEMMFSQTLSAHIGTGHLHGSTACSNPASL 1290
            :|...|   ||..|::.:.|..|.|.|.:|:::::..::..:.|
  Fly  1312 KPILIA---PHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCL--------------------- 1352

 Worm  1291 AGPSRKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQG 1355
              |..|.  ::..|.:..||.||:||.|.|.::|.:......:..::|:|:||.|..||...|..
  Fly  1353 --PVLKS--SKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTC 1413

 Worm  1356 PTQPEERLREDIRLLTRFFEHLKNDKHYMQKEALAKTD-KNLVMSST-MSQMQTNFEKSLLISG- 1417
            |.|..|:|.|||.:|.:|::.::::|.::....:...| .|..:||| |..::.|.|.:.||||
  Fly  1414 PNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGG 1478

 Worm  1418 ---TPVTATAAGTPNTSLM------LPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEE 1473
               ...|.:.:.:.|...|      ...|:.:.||:..|:      ::.|.||.:|  .:|..::
  Fly  1479 GLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHST------STLSKRSNRS--KRLQYQK 1535

 Worm  1474 DRRIKTWMKQRNMLMLLVANEIERLSAWLHPLALAQEDCALDSEEFLRGAFTQAKATGGEKNIWR 1538
            |...|.:||:||:::.|:|.|:|.|..|.:|.:|  .|..:..||    ..|:.:....:..:||
  Fly  1536 DSYDKDYMKKRNLILELLAVELEFLITWYNPNSL--PDLIVPGEE----QITEWRNRPYKSTVWR 1594

 Worm  1539 EQAQLAWDISPELAIQLPSRFRGSPELVKYVDVLVRGQPEPVAHIPEALPLFLGNGSTVFETSDM 1603
            :.|:|||..:|.||:.||.|.:.:..:.:.|..||...|..|.||||||.......:.:.|:.|:
  Fly  1595 DYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDL 1659

 Worm  1604 SHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYIS 1668
            .::|:|:..:|:.||:..: |.||.||::.||||:.|.||.|:.:|.||||:|||:|:|||||:.
  Fly  1660 VYILSWSPVTPIQALAYFS-RQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVV 1723

 Worm  1669 ELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIMQKILSQLEGAARRFHEAEF 1733
            |.|..::..||:::|||||||||||:.||:.:.|||.|:|||:.:.|.|::...|||:||:|.||
  Fly  1724 EFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREF 1788

 Worm  1734 KLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSGTPMQSAAK 1798
            ..|.::||:||.|:.|.||..||.|||.||:.:|::...||||||||::||:|||||||||||||
  Fly  1789 DFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAK 1853

 Worm  1799 APFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRQDM 1863
            ||:||||||.|||:.|||   .:|........::.|.:....|:.    ||||||||||||||||
  Fly  1854 APYLARFRVYRCGITELE---TRAMEVSNNPNSQEDAKMTLGVES----WQAAIFKVGDDVRQDM 1911

 Worm  1864 LALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQLGRQTDFGLYEYFKTQY 1928
            ||||::.:.||::..:||.:.:||||||||:|||||||||||:|||||||||||.||.|||:.||
  Fly  1912 LALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQY 1976

 Worm  1929 GDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLG 1993
            |||||:.||.||.|||:||||||:..:|||||||||||||||.||||||||||||||||||||:|
  Fly  1977 GDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIG 2041

 Worm  1994 FEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRGKTI 2058
            ||||.||::|||.||||||::..|:.|..|||.|:||||||..:.||||||||||.||||||:||
  Fly  2042 FEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTI 2106

 Worm  2059 NQLRARFAPEMNEKDAAKYMYSVITNCFLNIRSKMYDQLQYFQNEIPY 2106
            |.|:.||....|.|:||.:|.:||.|.:.|.|::.||.:||:||:|||
  Fly  2107 NLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY 2154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	79/175 (45%)
		PI4Kc_III_alpha	1781..2105	CDD:270711	212/323 (66%)
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	79/175 (45%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	212/323 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157584
Domainoid	1	1.000	592	1.000	Domainoid score	I100
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11171
Inparanoid	1	1.050	1217	1.000	Inparanoid score	I92
Isobase	1	0.950	-	0	Normalized mean entropy	S2354
OMA	1	1.010	-	-		QHG60094
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	1	1.000	-	-		FOG0002854
OrthoInspector	1	1.000	-	-		oto19596
orthoMCL	1	0.900	-	-		OOG6_101741
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4430
SonicParanoid	1	1.000	-	-		X2686
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750