DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gly-11 and Pgant9

DIOPT Version :9

Sequence 1:	NP_001022948.1	Gene:	gly-11 / 176647	WormBaseID:	WBGene00001636	Length:	605	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	225/680 - (33%)
Similarity:	337/680 - (49%)	Gaps:	121/680 - (17%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MLLLWRRKTVGLICLFSILLTIYLYVS--MYPEDNER--------VWNSGNA------------- 42
            |..:|||::..::.|.:..|.|:..::  :|.:|..|        ...:|:|
  Fly     1 MAFIWRRRSTTIVKLVAFALAIWFCIAFLVYTDDTRRRAAQEGAGASGAGSAPGVGGGAGGLGDP 65

Worm    43 ------------DIQRKHEKLNNGGQ-------------GRHDFD----------DDEGAEKDEE 72
                        |.......:..|||             |:|..|          .::..:|.:|
  Fly    66 IALALRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQPKKKPQE 130

Worm    73 DAVEKQNIAAPPLPKSFTTFP-DRSKEIEIDTDLLGKINGKAEDDLQVEGYKKYQFNGLLSDRIG 136
            |:   :.:..|  |.:|...| :..|.:.:..::..::. ||.||    |:.|..||..:||.|.
  Fly   131 DS---KKVIDP--PANFEENPGELGKPVRLPKEMSDEMK-KAVDD----GWTKNAFNQYVSDLIS 185

Worm   137 SRRKIKDSRNARC-SSLTYSDSLPAASIVVCYFNESPSVLIRMVNSIFDRTKPEHL-HEILLVDD 199
            ..|.:.|.|:|.| ....|..:||...:::|:.||:.:||:|.|:|:.||: |||| .:|:||||
  Fly   186 VHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRS-PEHLIGKIILVDD 249

Worm   200 SSEWSNATDEAIKYREKHIIQWEKVKFLKTDKNEGLIRAKIFGARRANGEVLVFLDSHCEVNEEW 264
            .|:..:..    :..|.:...:.||:.::..|.||||||:|.||..|...||.:||||||..|.|
  Fly   250 YSDMPHLK----RQLEDYFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGW 310

Worm   265 LPPLLDQIKQNRRRVVCPIIDIIDAITMKY---VESPVCTGGVNWAMTFKWDYP--------HRS 318
            |.||||:|.:|...||||:||:|...|::|   ....|..||.:|.:.|.| :|        |.|
  Fly   311 LEPLLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSW-HPVPERERKRHNS 374

Worm   319 YFEDPMNYVNPLKSPTMAGGLFAIDKEYFFEIGSYDEGMDVWGAENVEISVRIWTCGGELLIMPC 383
            ..|       |:.|||||||||:||:|:|..:|:||.|.|:||.||:|:|.:.|.|||.|.|:||
  Fly   375 TAE-------PVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPC 432

Worm   384 SRVGHIFRRQRPY----GIKTDSMGKNSVRLARVWLDEYLENFFEARPNYRTFTDYGDLTSRISL 444
            |.||||||::.||    |:..  :.|||||||.||:|||.:.::....|.:  .|:||::.|..|
  Fly   433 SHVGHIFRKRSPYKWRSGVNV--LKKNSVRLAEVWMDEYSQYYYHRIGNDK--GDWGDVSDRRKL 493

Worm   445 RRNLQCKPFKWYLENIYPEL-LPDNTPNQLNNQILVAGKKYLIKMANGTHCLSAENSQGRIANGN 508
            |.:|:||.|||||:|||||| :|.:  :..:.:|...|       ..|..||.|  ..|:.....
  Fly   494 RNDLKCKSFKWYLDNIYPELFIPGD--SVAHGEIRNLG-------YGGRTCLDA--PAGKKHQKK 547

Worm   509 RVEMRKCNHMERMQQWKYSSTNELRPMGSSRMCLD-SLRGISVILCHNQGAHQMWQV-SNAGKLY 571
            .|....|:.....|.|..|...|:|...|   ||| :.:.:::..||....:|.|.. .|..:|:
  Fly   548 AVGTYPCHRQGGNQYWMLSKAGEIRRDDS---CLDYAGKDVTLFGCHGGKGNQFWTYRENTKQLH 609

Worm   572 SRSVNKCATGSNDVSALSTLKFCSLANSFQ 601
            ..:..||...|.....| .::.||.:.|.|
  Fly   610 HGTSGKCLAISESKDKL-LMEECSASLSRQ 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gly-11	NP_001022948.1	pp-GalNAc-T	162..461	CDD:133004	141/314 (45%)
		Glyco_tranf_2_3	162..392	CDD:290369	109/241 (45%)
		RICIN	484..599	CDD:238092	28/116 (24%)
		Ricin_B_lectin	486..602	CDD:279046	30/118 (25%)
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	127/285 (45%)
		pp-GalNAc-T	213..510	CDD:133004	141/313 (45%)
		Ricin_B_lectin	521..640	CDD:279046	32/131 (24%)
		RICIN	523..642	CDD:238092	32/129 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920