DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spop-1 and rdx

DIOPT Version :9

Sequence 1:	NP_001022764.1	Gene:	spop-1 / 176422	WormBaseID:	WBGene00011815	Length:	451	Species:	Caenorhabditis elegans
Sequence 2:	NP_650326.3	Gene:	rdx / 41704	FlyBaseID:	FBgn0264493	Length:	829	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	272/452 - (60%)
Similarity:	335/452 - (74%)	Gaps:	38/452 - (8%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MILLAKFRNLYSKSRANDTISEGDKPEKATGDLEAGRNRLVSMEVGMGNDEVVSSGSGNSAHGRS 65
            ::||.|..|  ||...|...:..||             ||...|........|:|....|:...:
  Fly   408 LVLLVKCPN--SKEFCNAAANFCDK-------------RLPVNECQASQTARVTSNLHASSSTMA 457

Worm    66 IS--PSPSSASHGDPL----LPVAENWCHTQVKVVKFNYMWTINNFSFCREEMGEVLKSSTFSAG 124
            :|  |||       ||    .|||||||:||||||||:|||||||||||||||||||||||||||
  Fly   458 VSRVPSP-------PLPEVNTPVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAG 515

Worm   125 CNDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSILNAKREETKAMESQRAYRF 189
            .|||||||||:|||||||||:||||||||||.|||||||||||||||||||||||||||||||||
  Fly   516 ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRF 580

Worm   190 VQGKDWGFKKFIRRDFLLDEANGLLPGDRLSIFCEVSVVAETVNVTGQTNVSQLFKVPPCRLADD 254
            ||||||||||||||||||||||||||.|:|:|||||||||::||::||:|:.| ||||.|:|::|
  Fly   581 VQGKDWGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSVNISGQSNIVQ-FKVPECKLSED 644

Worm   255 MYGLFDNKQFSDFTLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEP 319
            :..||||::|||.||    .:|.  :.|..|||||||||.||:|||||.|:|...|...:.|::.
  Fly   645 LGNLFDNEKFSDVTL----SVGG--REFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDH 703

Worm   320 EVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNASLTLMLADMYS 384
            ||::|:|.::|||:...:|:||..|:||||||.|::||||||:|||..|:.:.|:.||:|||::|
  Fly   704 EVLKEMLRFIYTGKAPNLEKMADDLLAAADKYALEKLKVMCEEALCVNLSVETAAETLILADLHS 768

Worm   385 ASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRALATQQTPPVVLVQPPKKRPK 446
            |.||:|.:|:|||.:|.:||:|.||::::..|..|:.|.||||||||.||   :.||:||.|
  Fly   769 ADQLKAQTIDFINTHATDVMETSGWQNMITTHSHLIAEAFRALATQQIPP---IGPPRKRVK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spop-1	NP_001022764.1	MATH_SPOP	92..230	CDD:239743	129/137 (94%)
		BTB	255..365	CDD:279045	56/109 (51%)
		BTB	266..368	CDD:197585	52/101 (51%)
		SPOP_C	368..430	CDD:269807	30/61 (49%)
rdx	NP_650326.3	MATH_SPOP	483..621	CDD:239743	129/137 (94%)
		BTB	645..749	CDD:279045	56/109 (51%)
		BTB	656..752	CDD:197585	52/101 (51%)
		SPOP_C	752..814	CDD:269807	30/61 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I2377
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68354
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D864323at2759
OrthoFinder	1	1.000	-	-		FOG0000398
OrthoInspector	1	1.000	-	-		oto17627
orthoMCL	1	0.900	-	-		OOG6_101509
Panther	1	1.100	-	-	LDO	PTHR24413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2421
SonicParanoid	1	1.000	-	-		X131
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.950