DRSC/TRiP Functional Genomics Resources

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Protein Alignment gei-8 and Smr

DIOPT Version :9

Sequence 1:NP_498773.3 Gene:gei-8 / 176145 WormBaseID:WBGene00001565 Length:1778 Species:Caenorhabditis elegans
Sequence 2:NP_001259491.1 Gene:Smr / 32225 FlyBaseID:FBgn0265523 Length:3607 Species:Drosophila melanogaster


Alignment Length:2486 Identity:437/2486 - (17%)
Similarity:709/2486 - (28%) Gaps:1000/2486 - (40%)


- Green bases have known domain annotations that are detailed below.


 Worm    13 EKFKAFQDDLQ----KWEETSERKEYAEFHRVQAESEFPELKREREDRERWAR-AERIRGEDEKS 72
            ||:...|.|.|    :.|.:::||.....:|...|..|.||:::|||:||:.| ..||:.|.:..
  Fly   886 EKYTKDQADWQRRCERMEASAKRKAREAKNREFFEKVFTELRKQREDKERFNRVGSRIKSEADLE 950

 Worm    73 ML---AKEHA--DKKIRLGVAKIPRLLTESERKMDEFVERPGSILKDMKKEHRQSVLDRLEEWSP 132
            .:   .:|.|  |||:| ..|.||.|:.::.::...:....| :::||...|:|.  ..|..|:.
  Fly   951 EIMDGLQEQALEDKKMR-SYAVIPPLMHDARQRRCAYHNENG-LIEDMVAVHQQR--KALNMWTA 1011

 Worm   133 EERSLFKSRQADHVKIFHGLTEFFVDKTASDLVLFYYMNKKTEDYKKDFKPKKRVTKYKVGAFPS 197
            .|:..||.:...|.|.|..:......|:..|.|.:||::||||:||:..:..::.|:       |
  Fly  1012 GEKETFKEKYLQHPKNFGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTR-------S 1069

 Worm   198 VEELAYFRMMPPLDFSSFPKNSLMCYFCCRTVNGIDLNGTFMPKEAYEIFAICPDEDRVVCSGCR 262
            ....|..:...|           .|.....|...:    |.:.:|..:            .||.|
  Fly  1070 SRNPAKAQAAQP-----------QCIIDSMTTGVM----TRLQREQQQ------------KSGGR 1107

 Worm   263 EEAAKLYKDNRCFGNRCSNQKKRANRVNRNIPLDFADFPVRTRAFIMDKLGSTRV-AVKFCTPCK 326
            ..|..              :::||.|             ...|..:.:|..:... |.:......
  Fly  1108 SSAVA--------------ERERAER-------------AAERERVAEKAAADAAKAAESAAEKA 1145

 Worm   327 NALTRWINDVNNKEETIMAELLNYEGQVGWTDDEKTKLVTLINSSPTLDWVSISEGMNRRPNECK 391
            :|.|:.:......|:...|.    ...........|...|..:||.:....|.|.......:...
  Fly  1146 SAATKAVEATAAGEKVAKAA----AAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSSTAS 1206

 Worm   392 ------MQYDAMNGVKTQPMIEEVDEEDGNGQEEGGDALVNTPTTSSAAARRS----------GL 440
                  :..|..:..||      ....|.|....||.....|||.::..|..:          ..
  Fly  1207 PATLAGIAADKTDAGKT------ASASDKNAATAGGPTATGTPTAATTPATATAPPEISAGGEAK 1265

 Worm   441 ARNAKK---------PVRTPRAPRSAGGRRTGG---------AVTRAQAVPKPVEDLGEEIDEME 487
            ::||::         .|.|...|.:.....:.|         |...|:.|.||            
  Fly  1266 SKNAEEEAAATAGAATVATAGTPATGASAASAGEATTATGATATAAAKGVGKP------------ 1318

 Worm   488 IEDNDEDASRGSRGKDSKA----PSDRDGSPA-DMEGDSPEGQDQDADQDQDQDQDVDEEEEEVI 547
             |...|.|...::|.||:.    |..:..|.| :.||.:..|.:..:....              
  Fly  1319 -ETATEPAGTAAKGADSRPDANDPLAKTASKAINAEGYNAIGGNSSSSSSN-------------- 1368

 Worm   548 VRDIDSPVKTLLSPKILSGGHKPDFPPV------------------------------------- 575
            .....:||:     .:...|.||.:..|                                     
  Fly  1369 ATGASAPVQ-----GVTLNGFKPGYQTVVMANVKASTGGDDSGANAGGAAPGSLAATNASIATSG 1428

 Worm   576 PRIQKPSTSSQPPPPEPMDTKENESDDGEEDN----------------------------DILEI 612
            .:|.|.:.||: .|.....|..|||..|...|                            :.|..
  Fly  1429 DKIVKTTPSSR-APNSTSSTAANESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHS 1492

 Worm   613 DVDEPPAKRPTPTS-----SSSHLIGSSSVGGSERELGGRGLVQQQQQQQPQAQ------SAAPP 666
            ||.|...||....|     :::..:.:||..||.......||....:.....|:      |:|..
  Fly  1493 DVSESKRKRFELNSGEAGGNATSAMTNSSTSGSMNISNSHGLKANAKDGSMMAKTSMASTSSASV 1557

 Worm   667 VTVSTAAA-------ATAERLVNATSPSPSVASQHLVPTETSTSVPPVTIVPPAIQQP------- 717
            |..||.:|       |::..|::|.|...:.|.      .||:|....|....||..|       
  Fly  1558 VVTSTPSASSSSLSSASSMLLISAASVMSTAAG------ATSSSTATTTATASAISLPLLADGSG 1616

 Worm   718 --------VVVISG-------------AAPQFT-------QQ-----QTTHSPALIAQ------- 742
                    ::.:.|             |.|:..       ||     :|..:.|.:..       
  Fly  1617 NSMVNANEILALDGKDKLASCFVCKAEACPRTRPLKKGRGQQYGIPDETIPAGARVCNSCQCKSV 1681

 Worm   743 -------PIP---------QQL--IPQR-------VSTPAQI---LTPTPVR------------- 766
                   |:|         |:|  ||.|       |..|...   :.|...|             
  Fly  1682 RSRYPNCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEFQIPPHATRCCSACLMRIRRKL 1746

 Worm   767 ---------------------PTAASTPSMDQ---------------------FLGLFKQQQQQQ 789
                                 .|..||.|.|:                     .|.:.|||||||
  Fly  1747 DPQLNLTDGSSGGAGSGSGGDETDVSTSSCDEREPGGSDTASVESPENLQRHKSLTMVKQQQQQQ 1811

 Worm   790 QQQPQQSNLMQQLGNINPQFLALLLQQQQQQQQVQQAQVQ-----AAQTQGSL----TSGTPF-- 843
            |||.||.                  ||||||||.|.:|.|     ..|.:||.    ..|||.  
  Fly  1812 QQQQQQQ------------------QQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGTPLII 1858

 Worm   844 ------------QAQQRPD----------EALQKLFSSPEMLGTLLNAKYQFPQFPQAIQQNPLL 886
                        .||...|          :|.:|..:|.|...:......:..:...|.:|:|.:
  Fly  1859 TPTRMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPANRQSPKV 1923

 Worm   887 M----------NAQHQLILQQ------------------QQL---------AMQHAQ-------- 906
            :          :|.:...||.                  ||:         |:.:.|        
  Fly  1924 LFHGHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAGQQVNGPISMRREAVNNVQDCVFSVIE 1988

 Worm   907 ----AQAAQAAQAQAAQAAQAQAQAQAEAKLKTQAAQAKAQADAQARVQTQQQAH---------- 957
                .:..|....|..|..|.|.|.|.:.:   ...|:::.:..|.:.|.||.|:          
  Fly  1989 RSLKHKGPQPKGGQGQQQGQGQGQGQGQGQ---TPGQSQSPSQQQQQQQQQQSANNLERKELTIV 2050

 Worm   958 ---------LKAQAQAQYQMNRPQLIPASV--QMPIGINTAYHQKSLTPSETSASATPPAHRPRA 1011
                     ||.|.|.|.....|   |.|.  .:|.|.:.    :.||....:.:..|||| |..
  Fly  2051 REYRQDPGILKQQQQQQQAGGAP---PTSAAGSLPHGTSV----QKLTTRPAAVAPPPPAH-PLT 2107

 Worm  1012 ATTVGSKMPAGRSNVQEAELRTLK----------------------------------------- 1035
            .|:.|.   ||.:|.....|.||.                                         
  Fly  2108 PTSTGC---AGSNNGTSDSLATLSVVNSHMGMVGIGHPGPMAHASSAGGIGVDKATITPVVKSSS 2169

 Worm  1036 -------------------EELIKRIRLFRDRIAEDAHLKR-----EEENI-------VTYTAQI 1069
                               |.:|..:.:        ||.:|     .:.::       ..:.|..
  Fly  2170 GSSKSGGGSASSHSTATPPETIIYNVPV--------AHPQRGIPPPSQHSVHPAHPSHTQHPAHP 2226

 Worm  1070 QASRVQYNTEILGQMKQRYEQAAARRIE------------------------------------- 1097
            |.|....:|::  |:.:...|.....|:                                     
  Fly  2227 QHSSHGQHTQL--QVPEPEPQTLDLSIKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPP 2289

 Worm  1098 --------------------IVKELDEPAKF---------------INGVQNKFNDFSVF----- 1122
                                .|..|..|:.:               :.||.......:::     
  Fly  2290 PTMSMKHIVRSGGMYRGDTVTVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLPGVPGSALYLQPVP 2354

 Worm  1123 ------------------------------------KLDEIDRQTLHEILQRYAAEQKPDQLQQQ 1151
                                                ||.......||.......::|:..|.|||
  Fly  2355 VPVPISISGQGQLPPRAGQPPPAQPPSGRGVAKVPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQ 2419

 Worm  1152 QND--------------------------------------------------FHNLLRQ----- 1161
            |..                                                  |..|:||     
  Fly  2420 QQQQQQAAAAQQQLLVKSGSITHGTPANSAQQQIIVHAPATAAAAPSSLLSPKFDGLVRQTTPEG 2484

 Worm  1162 -NNIGIRQA----------QYPALQASPHQAAIIQHQQQQEAFKKLQQQHQDAQK----RKLEAP 1211
             .::|...|          |...|...||.   ::.::..|::.|..|:|..||:    ::|..|
  Fly  2485 VGSVGPGGASGSGKHGSITQGTPLHMPPHH---LESKRPYESYYKSSQRHSPAQQPGGNQQLPPP 2546

 Worm  1212 VSSATPQV---KRIALSQSSPVQRFSQHPNGTLPHNLAVVYQNKMPQDREKLLQEQQLNQYLFAA 1273
            ...::||.   :...:..|||   :::.|..      .||.|.::...|:.::.:...:|.:...
  Fly  2547 PQQSSPQAPPPQGYGVGVSSP---YARSPFA------GVVEQPQVLSTRQIVMHDYITSQQMQGQ 2602

 Worm  1274 QQQHLQQQQQHH---------------GTQPEQKSKRKS---------GIESITSMQGAPHRHIQ 1314
            |||..|||||..               |:..|..|.|.|         |.:..::.:|.|.    
  Fly  2603 QQQQQQQQQQQRNMSRGSSASGGGGGGGSDKESPSPRNSVGSASGFAYGGDKESAPRGRPE---- 2663

 Worm  1315 LAGPSSSRIQSGRGVSPALSASRSVAPTISGAAGRSITA---------------------GTSGH 1358
                .|||......|:...|..|:..|...|...|..|.                     ..|||
  Fly  2664 ----YSSRASPADHVNSTPSPHRTPPPQRQGVIQRHNTGSKPPSPAAPPPSRMHMPPYQYAPSGH 2724

 Worm  1359 SSTSDYNKELAERMNEVFKPTHPQLLQTKASAMNSNAVSPANTNNSDEIECVYQGPPKTPASIKR 1423
            .:.:.:.....::         |||              |..:...|:    ..||...|..:..
  Fly  2725 DALASFVDVAVQQ---------PQL--------------PVPSQKDDK----SPGPSTAPGQVPG 2762

 Worm  1424 LQPTEGPRTLSGQRMKSILSVPAHQRRSSIPPVKTEDEAMECLSMMMYEEAKAPPSDRIVTKLIS 1488
            ..|..||..|....:..:...|        ||....|:....|::..:...       :|.:.|:
  Fly  2763 SGPPLGPSPLPPHAVVGVAQPP--------PPTAHHDQRYRDLTLHHHHHT-------LVQQQIA 2812

 Worm  1489 SSEAAAAANPSAKFSYLDIFNDVVKRDEERCQRMLQSTSVLQPSRELDAFLQQLQQNPQQYANLS 1553
            ..:...:.|.:|:..        ::|..::.:|::         |.....:||.||..||..:..
  Fly  2813 QQQHYRSLNVAAQVD--------MQRQMDQAKRVM---------RHQQHQVQQQQQQQQQQQHNH 2860

 Worm  1554 AAEKLALQQYQIHSAHQKSQQQAQLQAAQQLQQQQQARPDHYEKFHLLRPNAEIVRPIPTTFSH- 1617
            |.|:....|.::....::.:::.:.:..::.:::::.|....|:    |......|.:.....| 
  Fly  2861 ALERDREMQERMRERDREREREREREQRERERERERERERERER----REQDRARRVVAEEREHD 2921

 Worm  1618 -------FLNKATTSTVSSSASAP---QFLQ-------PPAA-----------ASIAAPTPISTP 1654
                   |.....|.:..:....|   |||:       ||.:           .:...|.|..||
  Fly  2922 SRRMERMFAGNVVTGSGGAGGGGPSPGQFLRASVPETGPPRSIPDRERESYYRQAHGGPAPEDTP 2986

 Worm  1655 HAMPSPSV-----------------GVQTAPPTPQAVHHPVMPIIPGKPSSVNSNVSDVSSDDDD 1702
            ..:.:.|:                 |.....|.|..||.|:.|...|......:..|        
  Fly  2987 GQLSAQSLIDAIIKHEINRSNDATAGPGREFPRPSFVHAPLPPRGSGSGGGTGTRSS-------- 3043

 Worm  1703 VRNPEKLPANRLPPLPGDKTAFRSVIDLRATGHVAVTKKIPVKYPL------VVQAQNGIQPIKD 1761
                   |||.|.|:        .:.|||              .||      ::.|:|..:|...
  Fly  3044 -------PANVLHPM--------YLRDLR--------------QPLDGGAGSMLTAENNGKPSSS 3079

 Worm  1762 YGPPCKNLVYEDLSDD 1777
            ..|...|:   ||..:
  Fly  3080 GSPSVINI---DLDQE 3092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gei-8NP_498773.3 SANT 356..394 CDD:238096 6/43 (14%)
SANT 356..394 CDD:197842 6/43 (14%)
KAAG1 1308..1371 CDD:259486 14/83 (17%)
SmrNP_001259491.1 GPS2_interact 710..798 CDD:292412
TPH <725..1006 CDD:290579 37/123 (30%)
SANT 1009..1048 CDD:238096 10/38 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001675
OrthoInspector 1 1.000 - - oto20041
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2297
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.030

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