Protein Alignment DMPK and aPKC

DIOPT Version :10

• Sequence 1: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 114/336 - (33%)
• Similarity: 178/336 - (52%)
• Gaps: 32/336 - (9%)

Human    73 PPASESRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRG 137
            ||..|...||...|    :...:|||:::|||||::::|.:|::::|.::||||::.|..:....
  Fly   596 PPPPEDPLEPGTQR----QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDE 656

Human   138 EVSCFREERDVLVNGDRR-WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 201
            ::...:.|:.|....... ::..||..||..:.|:.|:|:..||||:..:.: ..|:|.|.||||
  Fly   657 DIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQR-QRRLPEEHARFY 720

Human   202 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK-LRADGTVRSLVAVGTPDYLS 265
            .|||.:|::.:|..|.::||:|.||:|||..|||:|.|:|.|.: :|...|..:.  .|||:|::
  Fly   721 AAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTF--CGTPNYIA 783

Human   266 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF-------YADSTAETYGKIVHYKEHL 323
            ||||:.       ..||...|||||||..|||..|::||       ..|...|.|...|..::.:
  Fly   784 PEILRG-------EDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTI 841

Human   324 SLPLVDEGVPEEARDFIQRLLCP-PETRLG---RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTP 382
            .:|   ..:...|...::..|.. |..|||   .....|..:||||..:||:.|  :...|||.|
  Fly   842 RIP---RSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKP 903

Human   383 DFEGATDTCNF 393
            ..:...|..||
  Fly   904 RLDSDRDLANF 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	108/314 (34%)
		DMPK_coil	496..556	CDD:117396
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	105/308 (34%)