Protein Alignment DMPK and wts

DIOPT Version :10

• Sequence 1: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_733403.1
• Gene: wts / 43651
• FlyBaseID: FBgn0011739
• Length: 1105
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 138/363 - (38%)
• Similarity: 207/363 - (57%)
• Gaps: 53/363 - (14%)

Human    78 SRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVV-KMKQTGQVYAMKIMNKWDMLKRGEVSC 141
            ::.|...:|||..::.:..|..||.||.|||.||.:| |:..:..:||||.:.|.|:|||.:|:.
  Fly   700 NQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLVSKIDTSNHLYAMKTLRKADVLKRNQVAH 764

Human   142 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 206
            .:.|||:|...|..|:.:|:::|||::.||.||:|..||||::||.|.| ....|:||||:||:.
  Fly   765 VKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIKLG-IFEEELARFYIAEVT 828

Human   207 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL--------------------------- 244
            .|:||||::|::||||||||||:||.|||:|.|||.|.
  Fly   829 CAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEPWE 893

Human   245 ---------------KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFA 294
                           ::|....|.:...||||:|::||:|:..|       |...||:|::||..
  Fly   894 EYSENGPKPTVLERRRMRDHQRVLAHSLVGTPNYIAPEVLERSG-------YTQLCDYWSVGVIL 951

Human   295 YEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDF 359
            |||..||.||.|:|..||..|::::::.|.:|...| :..||.|.|:||....:.|||: ...:.
  Fly   952 YEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAE-LSREATDLIRRLCASADKRLGK-SVDEV 1014

Human   360 RTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVE 397
            ::|.||.|:|:..:|....|:.|:.:..|||.|||.|:
  Fly  1015 KSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVD 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	134/346 (39%)
		DMPK_coil	496..556	CDD:117396
wts	NP_733403.1	MobB_LATS1	644..718	CDD:439273	4/17 (24%)
		STKc_LATS	717..1078	CDD:270749	134/346 (39%)