Protein Alignment DMPK and Pka-C1

DIOPT Version :10

• Sequence 1: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 313
• Identity: 108/313 - (34%)
• Similarity: 167/313 - (53%)
• Gaps: 30/313 - (9%)

Human    95 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQ 159
            ||||.:|.:|.|:|..|.:|:.|.|...|||||::|..::|..:|.....|:.:|......::..
  Fly    44 DDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVS 108

Human   160 LHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKP 224
            |.:.|:|.:.||:|:||..||::.:.|.|.| |.....:|||.|:||:|.:.:|.|..::||:||
  Fly   109 LRYHFKDNSNLYMVLEYVPGGEMFSHLRKVG-RFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKP 172

Human   225 DNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWA 289
            :|:|:|..|::::.|||...:::.    |:....|||:||:|||:.:.|       |....||||
  Fly   173 ENLLIDSQGYLKVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG-------YNKAVDWWA 226

Human   290 LGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET- 349
            |||..|||..|..||:||...:.|.||    |.:..|..         .:.:|.::.||....|
  Fly   227 LGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFG---------SDLKDLLRNLLQVDLTK 282

Human   350 RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 398
            |.|  :.|..|.:...:|...||..:  :....||.|..:|..||.|||..|:
  Fly   283 RYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEE 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	108/313 (35%)
		DMPK_coil	496..556	CDD:117396
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	107/309 (35%)