Protein Alignment DMPK and S6kII

DIOPT Version :10

• Sequence 1: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Sequence 2: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Alignment Length: 624
• Identity: 185/624 - (29%)
• Similarity: 264/624 - (42%)
• Gaps: 144/624 - (23%)

Human    43 GRLRTGPGQVRGRLLAVGPKSRVFQSVVQEPPASESRAEPIVVRLKEVRLQRDD------FEILK 101
            |.:.||     ||  ..|...|....:....|..|:..|   ..||||..:..|      ||:|:
  Fly   149 GGVETG-----GR--REGATGRSAPDLEDTEPLYETENE---FELKEVIKEGHDKADPSQFELLR 203

Human   102 VIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFA 163
            |:|.|:|.:|.:|:.   |..|.:||||::.|..:..:..|.. ..||.:|.:....:|.:||:|
  Fly   204 VLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRS-TNERKILADVGHAFIVRLHYA 267

Human   164 FQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 225
            ||....|||::::..||||.|.|||   |.|    |..:|||||:.:|::.:|.||.::||:||:
  Fly   268 FQTPGKLYLILDFLRGGDLFTRLSKEVMFTE----EDVKFYLAELALAMNHLHTLGIIYRDLKPE 328

Human   226 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 290
            |||||..|||.|.||| ..|...||: ::....||.:|::|||:...|       :....|||:.
  Fly   329 NILLDEHGHIALTDFG-LSKQPLDGS-KTYSFCGTVEYMAPEIVNRKG-------HDFAADWWSF 384

Human   291 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRG 354
            ||..|||..|..||:..:..||..:|:..|  |.:|   |.:..||:..::.|. ..|:.|||.|
  Fly   385 GVLMYEMLTGNLPFHGQTRQETMNQILRSK--LGMP---ENLSPEAQSLLRALFKRNPQNRLGAG 444

Human   355 GAG--DFRTHPFFFGLDWDGL-RDSV-PPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIR 415
            ..|  |.:.|.||..:||..| |..| |||.|.. ...|...||:.....:...|.||
  Fly   445 AQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGG------- 501

Human   416 EGAPL--GVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQL--LEP----HVQAPSLEPSVSPQD 472
               |:  ..|..|.|:|:....|.:.:..|.......|..|  :.|    .|.||...|.|.|.:
  Fly   502 ---PISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGN 563

Human   473 ETAE------------------------------VAVPAAVPAAEA--------EAEVTLR---- 495
            ..||                              |...|||.||..        |.|:.||
  Fly   564 FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNH 628

Human   496 ----ELQEALEE--------------EVLTR-----QSLSREMEAIRTDNQNFASQLREAEARNR 537
                .|....|:              |:|.|     |....|..|:.....:..:.|.|....:|
  Fly   629 PNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHR 693

Human   538 DLE------AHVRQLQERMEL--------LQAEGATAVT 562
            ||:      |.:||..|.::|        |:|:....:|
  Fly   694 DLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMT 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	127/355 (36%)
		DMPK_coil	496..556	CDD:117396	19/92 (21%)
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	123/343 (36%)
		STKc_RSK_C	567..883	CDD:270993	32/166 (19%)