Protein Alignment DMPK and dmpk

DIOPT Version :10

• Sequence 1: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Sequence 2: XP_009303323.2
• Gene: dmpk / 101886625
• -ID: -
• Length: 600
• Species: Danio rerio
• Alignment Length: 656
• Identity: 301/656 - (45%)
• Similarity: 374/656 - (57%)
• Gaps: 98/656 - (14%)

Human    22 GPGLPGAGAPARPSPGRPPGAGRLRTGPGQVRGRL-LAVGPKSRVFQSVVQEPPASESR------ 79
            |||..||.    ....|.||||.|..||..::..| |.||    |:|.....|...|..
Zfish     4 GPGPSGAA----HLQDREPGAGGLAEGPVGLQTLLDLLVG----VYQEFCSSPLRREKHVQRFLQ 60

Human    80 -AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFR 143
             |||:|.::|:.|:.|:||.||||||||.|||||:.:|:.|.||||:|||||||||||||::|::
Zfish    61 WAEPLVRQVKKTRISREDFHILKVIGRGTFSEVALARMRNTQQVYAVKIMNKWDMLKRGEMACYQ 125

Human   144 EERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMA 208
            |||:||:.|||||||:||:||||::||||||.||||||||||||||.:.:|.|||:|||||:|||
Zfish   126 EEREVLLKGDRRWITELHYAFQDDDYLYLVMHYYVGGDLLTLLSKFNDGLPEEMAQFYLAEMVMA 190

Human   209 IDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 273
            |||||.|||||||||||||||...||.||.||||||:|..||.|.|.||||||||||||:|:||.
Zfish   191 IDSVHLLGYVHRDIKPDNILLTADGHARLGDFGSCLRLEDDGLVHSAVAVGTPDYLSPELLRAVE 255

Human   274 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARD 338
            .|   |.||.:||||||||.||||..|.|||||:|.:|||.||:|:|::...|.....|.|.||.
Zfish   256 AG---GGYGSDCDWWALGVCAYEMLLGTTPFYAESISETYAKIIHFKDYFGFPASGVQVSEPARA 317

Human   339 FIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAM 403
            .:..|||....|||.||:.|||:||||.||||..|....||:.||...||||.|||:::|.|:..
Zfish   318 LVCSLLCERSERLGSGGSADFRSHPFFSGLDWSSLHLHPPPYRPDVSNATDTSNFDVLDDCLSET 382

Human   404 VSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS-EVPGPTPMELEAEQLLEPHVQAPSLEPS 467
                 |||||:.|.||:||||.||||||:  |.|:: .:...:.:.:|.:||.:        ..|
Zfish   383 -----ETLSDVMERAPVGVHLAFVGYSYT--ATRETGALDRSSDIMMEIDQLQD--------TDS 432

Human   468 VSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLT------------RQSLSREMEAIRT 520
            :..||:..:|                 .:|:|.:..|||:            |...|.|.|...|
Zfish   433 LHLQDKLDQV-----------------WQLRETITAEVLSAPESPAEKNNPERVDRSTETEQSDT 480

Human   521 DNQNFASQLREAEARNRDLEAHVRQLQERM-----------ELLQAEGATAVTGVPSPRATD--- 571
            ..|.....|.:||.|||:||..:..|:|::           ||.....|.|:...|...|.|
Zfish   481 HVQELQRHLHKAERRNRELEQEMAGLREQILRLSAVRNTVTELCVCPPARALAVCPLDSAQDSSV 545

Human   572 -PPSHMAPRPWLWASARWWGQAPCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAALGWW 635
             ||:                   |.......|...|.|..|.|.|...|..:.||......|..|
Zfish   546 TPPA-------------------CHYPLVTPLHRHLLLFNRVRVPQVSSESYLLVCAVGQELQLW 591

Human   636 PTPANS 641
            ....|:
Zfish   592 ERHLNT 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	220/336 (65%)
		DMPK_coil	496..556	CDD:117396	23/82 (28%)
dmpk	XP_009303323.2	None