Protein Alignment thoc-2 and tho2

DIOPT Version :10

• Sequence 1: NP_498392.2
• Gene: thoc-2 / 175900
• WormBaseID: WBGene00015813
• Length: 1437
• Species: Caenorhabditis elegans
• Sequence 2: NP_608646.3
• Gene: tho2 / 326153
• FlyBaseID: FBgn0031390
• Length: 1642
• Species: Drosophila melanogaster
• Alignment Length: 1611
• Identity: 471/1611 - (29%)
• Similarity: 765/1611 - (47%)
• Gaps: 319/1611 - (19%)

 Worm    30 TEKKD------------RDAISSELIDVLVLTEPESEFADNASTSKENFESFVNLL--TNTIIPE 80
            |.|||            .....|.::||:.:.:.|:....:.  .:|...:||.|:  .:.:|||
  Fly   118 THKKDIVLHLLLEVVALHADFPSLIVDVVNILDSETSLITDG--LQEERHAFVQLVKDLDRVIPE 180

 Worm    81 EIL--RLELDCFK-------KDDHSKALIRLKTKVYFKQAKFNLFREESEGYSKLVTELMEAAES 136
            .:|  |||:|..:       |..:|| .|::|||:|:||.:||||||||||::||:|||.:..:.
  Fly   181 SLLKERLEIDTLQEAGIVKNKSFYSK-FIKVKTKLYYKQRRFNLFREESEGFAKLITELNQEFDE 244

 Worm   137 SANENEHAKILKHRVLSLIGQFNLDPNRVTDVILEVFENFPRQKLLFIALLKEIDVVRDYLCALL 201
            :........|:|    ||||.||||||||.|:|:|.||..|.:..|||.||:........:|.:|
  Fly   245 NTTPESIMDIIK----SLIGCFNLDPNRVLDIIIESFETRPDRWNLFIPLLRSYMPTGAIICEVL 305

 Worm   202 GFKFTFYQSDKKKKTPYSLYVLTASLIQHEMIDMMKILGYMIPKAEAIKEGHRSRMQNAQERASK 266
            |:||..:   |..:||.|||.:.|.|::|.:|.:..:..::.|...:||......:.:|:|...|
  Fly   306 GYKFCHF---KDSRTPRSLYHVCALLLKHGVIALNDVYVWLTPNDGSIKADWEEDLADAREMVRK 367

 Worm   267 AETISTASMPIMDSRGFDENGIGGNATTQTISFTTVIQLQEDE-------DIKLSEGFNEEYVLS 324
            ...|.|                               ..:|||       .:|   .|||| ..:
  Fly   368 LNLIQT-------------------------------NKKEDEKDPPPPPSVK---KFNEE-KYN 397

 Worm   325 SNQKLGLTCALLESGNWKQAQMLIDRLPEYYAVQASPRLCRALCKIIEKSINDFYKKNC------ 383
            :|||.||..|||:.|:|:.|..:|.:|||...|...| :.||:..:|..|:.:.|.|.|
  Fly   398 ANQKFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEP-IARAIADLIHLSVENIYYKKCFKAPAG 461

 Worm   384 ---SLNL---------------FGDLIKSTKPVLDDMGNGLRPIESWEDLGKLSSVLAYLGPRIA 430
               |.|.               ||||.|.|.|    |.|.|.|...::      :||.|
  Fly   462 RRPSRNRLYEDSKLVAKMQAKEFGDLRKYTWP----MANVLGPAMHYD------TVLMY------ 510

 Worm   431 FRASTNIKIVRLLTAYYRKVDKDLL---PKDDKLNQNFVEVVSE---CLLPSLTLSETNVALSEE 489
                   |::|::......:..|.|   |.:.:..|::.:::|.   |:||||...:.|.::|||
  Fly   511 -------KLIRIMRKLVVDMGVDSLNGPPPNSEAEQHYYDIMSSLDACILPSLLYLDNNCSMSEE 568

 Worm   490 IWQLLELFPYSWRYWMYSKWNLETSR-HPEMHIMKGKIHGRTKYVLKRLSKETVKMMGRQLGKLC 553
            ||.:|:.|||.:||.:|::|..::.: ||.:....|......|.::||:|||.||.:||.:||..
  Fly   569 IWAVLKYFPYHFRYSLYARWKNDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLGRLVGKYS 633

 Worm   554 HIHPSTVLSYLLSQVQTFDNFIGPVVDSLRYLTSLEFDVLTYCIISQLADPSKQALKSTDATISP 618
            |..|..:..|:|.|:|.:||.||||.|.|:|||:|.||.|.||||..|....:...|....::|.
  Fly   634 HCAPGLLFDYILLQIQIYDNLIGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKDDGTSLSL 698

 Worm   619 WLQALGTLVGSLYRRYPLELNGMLDYVLNQLKLCKSYDMLLLREIIQNMSWIESISGATKEQIEA 683
            |||:|.:..|::|::|.:||:|:|.||.||||..||.|:|:||||:..|:.:||....|.:|::|
  Fly   699 WLQSLASFCGTIYKKYSIELSGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEMTNDQLQA 763

 Worm   684 LGGGDLLKQEAGGYSTATKNRKAAQRLRDALLKGDLAVGLAISVAQQKEHIVYNESST-LPLKLV 747
            :.||:.|:.|||.:|.....:|::.||::||...||||.:.:.:||||..::|.|::. ..||||
  Fly   764 MCGGEQLRGEAGYFSQVRNTKKSSNRLKEALANNDLAVAICLLMAQQKHCVIYRETAAHSHLKLV 828

 Worm   748 GKMVDQCSDTFQQLVSFLSVYLKNDDFSKRVPTVRELLSDYSLGMEATMCLARPIFFSRISDHYD 812
            |.:.|||.||..|..:||......|::.:|:|::..:|.:|.:..:....||||:|..:|:..||
  Fly   829 GNLYDQCQDTLVQFGTFLGSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTHQINQKYD 893

 Worm   813 AAKKISKAAVEDGQKTRLDTQQKTEMFTSALESQVEMLMDELKASEPG-MEENIPVKFFAVFWML 876
            ..:|      :|....:|.|.||.:.:..|.:..:..:::.::..... :.|:|..:|...||.|
  Fly   894 QLRK------DDPNAKKLTTTQKLQKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWSL 952

 Worm   877 TMYDIEVPTAAYERTLDALKKQSREDSHGKAKKTDKQ---------LESKLREEQKRQIEHVERC 932
            :|||:.||..:|:|.:..||:.:::.:.||.....|.         |..||.:|:|:|.|||::.
  Fly   953 SMYDLHVPNESYQREVAKLKQLAQQAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEHVDKI 1017

 Worm   933 KVWLLNKKDSLI----DEQFHNSVLEALIQQCLLPRAIFSELDAVFCGQFFMMLHEMRTPFFPSV 993
            ...|..:|||..    .:...|..:...:|.||.||..|:.|||::|.:|...:|.::|..|.::
  Fly  1018 SQRLQEQKDSWFLLRSGKSAKNDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFSTL 1082

 Worm   994 LIIDRLFENIIPLIAGLTENEANSLACFFEILLCTVQRWHSEKEVFEKECAGFPGMITK------ 1052
            |..||:|.:|...:...||.||.....|...:|.||.|||:::.||.||||.:||.:||
  Fly  1083 LCYDRIFCDITYSVTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSNQ 1147

 Worm  1053 -----QAIEYQTFRKLCYRWQIRFTAMFKTVFTKDDADYVLIRNSLIMMTKLTSGFPVISHAVAT 1112
                 ..:.|:.:|.:|::|..:.|...  ||..|..|::.|||:||::.::...:||:|.....
  Fly  1148 FSEANDHVGYENYRHVCHKWHYKITKAI--VFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQI 1210

 Worm  1113 METAVTKLKDREKGKRDDLSLKAASYVGKLKMRTVKIYAQN--SDYAPVPNKK--VSVGAEKPKK 1173
            :|..|.|:::.||.||.||...|:||:|:||::|..:..::  ...|..|||:  .||||.....
  Fly  1211 IERKVDKVREEEKTKRPDLYAIASSYIGQLKLKTPHMLKESVFHQIAERPNKESPTSVGAPAAAT 1275

 Worm  1174 KEKVVDEKDKADGEPVDKKIKVDSKKN--GT-----------TSSEKVVKDDEVHQNGSETEKKA 1225
            :.              ||........|  ||           :..:.|:|         |.:.||
  Fly  1276 RS--------------DKLSPTSPSGNTQGTRAPGGAAPFYNSEQKSVIK---------EPDAKA 1317

 Worm  1226 TVDNKERKKRPGKSSHGSKESKKEPTTEDGEVKTPSPPPAKKTRIVDRLKRSDEPSKKDEKESPK 1290
            ....:|.|.:.|:.::.:..|....|..:.|.::               |:.|.|:.::.:...|
  Fly  1318 ASTTRESKSQRGEGNNVTLVSTATSTASNNERES---------------KQRDLPAPRESQSRSK 1367

 Worm  1291 DTESEK---GEGKKRRERSKDKETGKEKRLEKDN---------------KEREKDKERKRENGEN 1337
            |.:.|:   |....|:..|::::..:::..::|.               |||.:.:..:|....:
  Fly  1368 DDQQEQANNGSNGSRQSESRNRDVERDRHDQQDQRSISSHRSSRDIVRVKERTEAELHQRSRERS 1432

 Worm  1338 QKEQKILKDQKQKSKPS----DEKLEVA-GPALPDPVPKKDD----------------------- 1374
            |:.:::...|:::.|.|    :|::... |....|.|...|:
  Fly  1433 QRLEELEAQQRKREKTSRRGGEERIRHGDGVETVDLVGSTDNRHYEEFEGRMRDLSSVSNESNGS 1497

 Worm  1375 ---KKGSRKAIEFDLEEPSK-----STSSS---------------------------------RK 1398
               ::.|.:.|||:..:..:     |||||                                 ||
  Fly  1498 LHHRQRSHETIEFEKVDSKRRKLESSTSSSKKVEELVDSVKKARALKTKERNKDKLSDEERDARK 1562

 Worm  1399 DRK-------------DDRKEKKEELPKASRIAEPARDAGKSGRDRGHRTF 1436
            |||             ::.|.::|.......:.:..|...||.|:|.|..|
  Fly  1563 DRKLGRKRDRVDESNSNEHKRRREGQNGEEELRDRERHREKSPRERSHEKF 1613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thoc-2	NP_498392.2	THOC2_N	36..547	CDD:465032	174/559 (31%)
		Thoc2	549..623	CDD:463334	33/73 (45%)
		Tho2	863..1142	CDD:463251	102/302 (34%)
		PTZ00121	<1190..>1424	CDD:173412	56/346 (16%)
tho2	NP_608646.3	THOC2_N	135..627	CDD:465032	174/560 (31%)
		Thoc2	629..703	CDD:463334	33/73 (45%)
		Tho2	939..1240	CDD:463251	102/302 (34%)
		DUF5401	<1348..>1617	CDD:375164	47/281 (17%)