DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment thoc-2 and tho2

DIOPT Version :9

Sequence 1:	NP_498392.2	Gene:	thoc-2 / 175900	WormBaseID:	WBGene00015813	Length:	1437	Species:	Caenorhabditis elegans
Sequence 2:	NP_608646.3	Gene:	tho2 / 326153	FlyBaseID:	FBgn0031390	Length:	1642	Species:	Drosophila melanogaster

Alignment Length:	1611	Identity:	471/1611 - (29%)
Similarity:	765/1611 - (47%)	Gaps:	319/1611 - (19%)

- Green bases have known domain annotations that are detailed below.

Worm    30 TEKKD------------RDAISSELIDVLVLTEPESEFADNASTSKENFESFVNLL--TNTIIPE 80
            |.|||            .....|.::||:.:.:.|:....:.  .:|...:||.|:  .:.:|||
  Fly   118 THKKDIVLHLLLEVVALHADFPSLIVDVVNILDSETSLITDG--LQEERHAFVQLVKDLDRVIPE 180

Worm    81 EIL--RLELDCFK-------KDDHSKALIRLKTKVYFKQAKFNLFREESEGYSKLVTELMEAAES 136
            .:|  |||:|..:       |..:|| .|::|||:|:||.:||||||||||::||:|||.:..:.
  Fly   181 SLLKERLEIDTLQEAGIVKNKSFYSK-FIKVKTKLYYKQRRFNLFREESEGFAKLITELNQEFDE 244

Worm   137 SANENEHAKILKHRVLSLIGQFNLDPNRVTDVILEVFENFPRQKLLFIALLKEIDVVRDYLCALL 201
            :........|:|    ||||.||||||||.|:|:|.||..|.:..|||.||:........:|.:|
  Fly   245 NTTPESIMDIIK----SLIGCFNLDPNRVLDIIIESFETRPDRWNLFIPLLRSYMPTGAIICEVL 305

Worm   202 GFKFTFYQSDKKKKTPYSLYVLTASLIQHEMIDMMKILGYMIPKAEAIKEGHRSRMQNAQERASK 266
            |:||..:   |..:||.|||.:.|.|::|.:|.:..:..::.|...:||......:.:|:|...|
  Fly   306 GYKFCHF---KDSRTPRSLYHVCALLLKHGVIALNDVYVWLTPNDGSIKADWEEDLADAREMVRK 367

Worm   267 AETISTASMPIMDSRGFDENGIGGNATTQTISFTTVIQLQEDE-------DIKLSEGFNEEYVLS 324
            ...|.|                               ..:|||       .:|   .|||| ..:
  Fly   368 LNLIQT-------------------------------NKKEDEKDPPPPPSVK---KFNEE-KYN 397

Worm   325 SNQKLGLTCALLESGNWKQAQMLIDRLPEYYAVQASPRLCRALCKIIEKSINDFYKKNC------ 383
            :|||.||..|||:.|:|:.|..:|.:|||...|...| :.||:..:|..|:.:.|.|.|
  Fly   398 ANQKFGLCEALLKVGDWENAYKIIQKLPEQAVVLQEP-IARAIADLIHLSVENIYYKKCFKAPAG 461

Worm   384 ---SLNL---------------FGDLIKSTKPVLDDMGNGLRPIESWEDLGKLSSVLAYLGPRIA 430
               |.|.               ||||.|.|.|    |.|.|.|...::      :||.|
  Fly   462 RRPSRNRLYEDSKLVAKMQAKEFGDLRKYTWP----MANVLGPAMHYD------TVLMY------ 510

Worm   431 FRASTNIKIVRLLTAYYRKVDKDLL---PKDDKLNQNFVEVVSE---CLLPSLTLSETNVALSEE 489
                   |::|::......:..|.|   |.:.:..|::.:::|.   |:||||...:.|.::|||
  Fly   511 -------KLIRIMRKLVVDMGVDSLNGPPPNSEAEQHYYDIMSSLDACILPSLLYLDNNCSMSEE 568

Worm   490 IWQLLELFPYSWRYWMYSKWNLETSR-HPEMHIMKGKIHGRTKYVLKRLSKETVKMMGRQLGKLC 553
            ||.:|:.|||.:||.:|::|..::.: ||.:....|......|.::||:|||.||.:||.:||..
  Fly   569 IWAVLKYFPYHFRYSLYARWKNDSYQLHPNLIRRCGLAQRDIKALMKRVSKENVKQLGRLVGKYS 633

Worm   554 HIHPSTVLSYLLSQVQTFDNFIGPVVDSLRYLTSLEFDVLTYCIISQLADPSKQALKSTDATISP 618
            |..|..:..|:|.|:|.:||.||||.|.|:|||:|.||.|.||||..|....:...|....::|.
  Fly   634 HCAPGLLFDYILLQIQIYDNLIGPVCDLLKYLTALSFDCLGYCIIESLTLTGRLRFKDDGTSLSL 698

Worm   619 WLQALGTLVGSLYRRYPLELNGMLDYVLNQLKLCKSYDMLLLREIIQNMSWIESISGATKEQIEA 683
            |||:|.:..|::|::|.:||:|:|.||.||||..||.|:|:||||:..|:.:||....|.:|::|
  Fly   699 WLQSLASFCGTIYKKYSIELSGLLQYVANQLKSQKSLDLLILREIVHKMAGVESCEEMTNDQLQA 763

Worm   684 LGGGDLLKQEAGGYSTATKNRKAAQRLRDALLKGDLAVGLAISVAQQKEHIVYNESST-LPLKLV 747
            :.||:.|:.|||.:|.....:|::.||::||...||||.:.:.:||||..::|.|::. ..||||
  Fly   764 MCGGEQLRGEAGYFSQVRNTKKSSNRLKEALANNDLAVAICLLMAQQKHCVIYRETAAHSHLKLV 828

Worm   748 GKMVDQCSDTFQQLVSFLSVYLKNDDFSKRVPTVRELLSDYSLGMEATMCLARPIFFSRISDHYD 812
            |.:.|||.||..|..:||......|::.:|:|::..:|.:|.:..:....||||:|..:|:..||
  Fly   829 GNLYDQCQDTLVQFGTFLGSTYSVDEYVERLPSIITMLREYHINTDVAFFLARPMFTHQINQKYD 893

Worm   813 AAKKISKAAVEDGQKTRLDTQQKTEMFTSALESQVEMLMDELKASEPG-MEENIPVKFFAVFWML 876
            ..:|      :|....:|.|.||.:.:..|.:..:..:::.::..... :.|:|..:|...||.|
  Fly   894 QLRK------DDPNAKKLTTTQKLQKYLEATQLIMNPIVESVRPLHSSKVWEDISPQFLVTFWSL 952

Worm   877 TMYDIEVPTAAYERTLDALKKQSREDSHGKAKKTDKQ---------LESKLREEQKRQIEHVERC 932
            :|||:.||..:|:|.:..||:.:::.:.||.....|.         |..||.:|:|:|.|||::.
  Fly   953 SMYDLHVPNESYQREVAKLKQLAQQAAEGKDSNQSKNKKEQERYIALMEKLNDERKKQHEHVDKI 1017

Worm   933 KVWLLNKKDSLI----DEQFHNSVLEALIQQCLLPRAIFSELDAVFCGQFFMMLHEMRTPFFPSV 993
            ...|..:|||..    .:...|..:...:|.||.||..|:.|||::|.:|...:|.::|..|.::
  Fly  1018 SQRLQEQKDSWFLLRSGKSAKNDTITQFLQLCLFPRCTFTALDALYCAKFVHTIHNLKTSNFSTL 1082

Worm   994 LIIDRLFENIIPLIAGLTENEANSLACFFEILLCTVQRWHSEKEVFEKECAGFPGMITK------ 1052
            |..||:|.:|...:...||.||.....|...:|.||.|||:::.||.||||.:||.:||
  Fly  1083 LCYDRIFCDITYSVTSCTEGEATRYGRFLCAMLETVMRWHADQAVFNKECANYPGFVTKFRVSNQ 1147

Worm  1053 -----QAIEYQTFRKLCYRWQIRFTAMFKTVFTKDDADYVLIRNSLIMMTKLTSGFPVISHAVAT 1112
                 ..:.|:.:|.:|::|..:.|...  ||..|..|::.|||:||::.::...:||:|.....
  Fly  1148 FSEANDHVGYENYRHVCHKWHYKITKAI--VFCLDSKDFMQIRNALIILMRILPHYPVLSKLAQI 1210

Worm  1113 METAVTKLKDREKGKRDDLSLKAASYVGKLKMRTVKIYAQN--SDYAPVPNKK--VSVGAEKPKK 1173
            :|..|.|:::.||.||.||...|:||:|:||::|..:..::  ...|..|||:  .||||.....
  Fly  1211 IERKVDKVREEEKTKRPDLYAIASSYIGQLKLKTPHMLKESVFHQIAERPNKESPTSVGAPAAAT 1275

Worm  1174 KEKVVDEKDKADGEPVDKKIKVDSKKN--GT-----------TSSEKVVKDDEVHQNGSETEKKA 1225
            :.              ||........|  ||           :..:.|:|         |.:.||
  Fly  1276 RS--------------DKLSPTSPSGNTQGTRAPGGAAPFYNSEQKSVIK---------EPDAKA 1317

Worm  1226 TVDNKERKKRPGKSSHGSKESKKEPTTEDGEVKTPSPPPAKKTRIVDRLKRSDEPSKKDEKESPK 1290
            ....:|.|.:.|:.::.:..|....|..:.|.::               |:.|.|:.::.:...|
  Fly  1318 ASTTRESKSQRGEGNNVTLVSTATSTASNNERES---------------KQRDLPAPRESQSRSK 1367

Worm  1291 DTESEK---GEGKKRRERSKDKETGKEKRLEKDN---------------KEREKDKERKRENGEN 1337
            |.:.|:   |....|:..|::::..:::..::|.               |||.:.:..:|....:
  Fly  1368 DDQQEQANNGSNGSRQSESRNRDVERDRHDQQDQRSISSHRSSRDIVRVKERTEAELHQRSRERS 1432

Worm  1338 QKEQKILKDQKQKSKPS----DEKLEVA-GPALPDPVPKKDD----------------------- 1374
            |:.:::...|:::.|.|    :|::... |....|.|...|:
  Fly  1433 QRLEELEAQQRKREKTSRRGGEERIRHGDGVETVDLVGSTDNRHYEEFEGRMRDLSSVSNESNGS 1497

Worm  1375 ---KKGSRKAIEFDLEEPSK-----STSSS---------------------------------RK 1398
               ::.|.:.|||:..:..:     |||||                                 ||
  Fly  1498 LHHRQRSHETIEFEKVDSKRRKLESSTSSSKKVEELVDSVKKARALKTKERNKDKLSDEERDARK 1562

Worm  1399 DRK-------------DDRKEKKEELPKASRIAEPARDAGKSGRDRGHRTF 1436
            |||             ::.|.::|.......:.:..|...||.|:|.|..|
  Fly  1563 DRKLGRKRDRVDESNSNEHKRRREGQNGEEELRDRERHREKSPRERSHEKF 1613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc-2	NP_498392.2	THOC2_N	35..547	CDD:292752	174/560 (31%)
		Thoc2	549..623	CDD:288568	33/73 (45%)
		Tho2	863..1142	CDD:288156	102/302 (34%)
		RNA_polI_A34	1192..1342	CDD:285426	29/180 (16%)
		RSB_motif	1291..>1354	CDD:292910	13/80 (16%)
tho2	NP_608646.3	THOC2_N	133..627	CDD:292752	174/562 (31%)
		Thoc2	629..703	CDD:288568	33/73 (45%)
		Tho2	939..1240	CDD:288156	102/302 (34%)
		PRP38_assoc	1570..1639	CDD:289628	9/44 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167453
Domainoid	1	1.000	190	1.000	Domainoid score	I1924
eggNOG	1	0.900	-	-		E1_KOG1874
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69669
Inparanoid	1	1.050	658	1.000	Inparanoid score	I401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55273
OrthoDB	1	1.010	-	-		D979205at2759
OrthoFinder	1	1.000	-	-		FOG0003449
OrthoInspector	1	1.000	-	-		oto19448
orthoMCL	1	0.900	-	-		OOG6_102850
Panther	1	1.100	-	-	LDO	PTHR21597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3684
SonicParanoid	1	1.000	-	-		X2346
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840