DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DMP1 and CG1647

DIOPT Version :9

Sequence 1:	XP_011530007.1	Gene:	DMP1 / 1758	HGNCID:	2932	Length:	542	Species:	Homo sapiens
Sequence 2:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	122/556 - (21%)
Similarity:	203/556 - (36%)	Gaps:	123/556 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    46 LPVTRYQN--NESEDSEEWKGHL--AQAPTPP--LESSESSEGSKVSSEEQANEDPSDSTQSEEG 104
            :|:|::::  ||||.|||....:  :|....|  :|.....:.|.|:|.....|:.....::||.
  Fly   622 IPMTQFESSLNESERSEEVDEAMIQSQEDVKPNRMELDRMMQISNVTSGVDMAEEAMALERAEEA 686

Human   105 LGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDD-----------SGDDTFGDDDSGPGPKDRQEG 158
            ...|....:..:.....:||| |.:.|......           ||:..|......|.|::...|
  Fly   687 CPEDSLHKVKSVKSTARKSTG-GAERKTYSPPRTNTLPQIVAVVSGESAFNMISIKPEPRNLGYG 750

Human   159 GNSRLGSDEDSDDTIQASEESAPQGQ-----------DSAQDTTSESRELDNEDRVDSKPEGGDS 212
                   ||:.:|..:.:||......           |.:..:..:.||||..: :|:....|..
  Fly   751 -------DEEPEDQRETTEEINHNDMMEEEKEYIGSLDLSDVSVKQERELDICE-IDAVHRNGLE 807

Human   213 TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ 277
            ..:.:.::     |::..:|..|.:|   |.|:.|..|.|..|.....:......|::..| ||:
  Fly   808 KSDEDDDD-----GNEDSASSADEAE---EAMERDTEERIYREIELPPLELQNESSRKDLE-SER 863

Human   278 ANTQDSGGSQLLEHPS--RKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRR 340
            .:|:.|......|.||  |.:....: ||....|.:..|...:.|...|...||..:..:
  Fly   864 MDTEVSTALPASETPSQTRDVLGVEK-SEASAFSLVITNICSQAVPQPSAACSNDIECSI----- 922

Human   341 DSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE-----SQEEVVSESRGDNPD-- 398
               |.|...:.|..| ...:||..|:::....|.::....|..     ||....|||:.|..|
  Fly   923 ---GPSPSTTNEPHS-HTVENVQSPANDLQTSAQVAIAAQSQPDPCIVSQPAASSESQADTKDLP 983

Human   399 PTTS------------YVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP 451
            |..|            :|..:.:.:|.|.|:|:.      ||| .|.|.:|:     ..|:|...
  Fly   984 PAASQIQTFNTESLPIHVHSETEDNSIENDASYL------ESR-AQVDCQSA-----GTENPSVV 1036

Human   452 EDENSSSQEG-----LQSHSSSAESQSEESHSEEDDSD-------------SQDSSRSKE----- 493
            .::|.|...|     :..:.|...|..:...||..|..             |.|:.:..|
  Fly  1037 LEQNESLPSGSCVSPIPENPSPGNSPPQHDESESLDKPEMAAGSAYCLATVSLDAPKDTEALALP 1101

Human   494 -------DSNSTESKSSSEEDGQLKNIEIESRKLTV 522
                   |||.|    |.||...:.|.|:..::|.:
  Fly  1102 PCDAAIIDSNYT----SDEEQQNVLNHELSEQQLAI 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DMP1	XP_011530007.1	DMP1	30..542	CDD:284637	122/556 (22%)
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071
		C2H2 Zn finger	203..224	CDD:275368
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	297..314	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900