DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mpk-1 and rl

DIOPT Version :9

Sequence 1:	NP_001022584.1	Gene:	mpk-1 / 175545	WormBaseID:	WBGene00003401	Length:	444	Species:	Caenorhabditis elegans
Sequence 2:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	342	Identity:	268/342 - (78%)
Similarity:	304/342 - (88%)	Gaps:	0/342 - (0%)

- Green bases have known domain annotations that are detailed below.

Worm    80 NNVEEVHGQLFEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIK 144
            :|.|.:.||:|||.|||:.|:||||||||||.||.||:|..||||||||||||||:||||||||.
  Fly    22 SNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREIT 86

Worm   145 ILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGLK 209
            ||.||||||||:|::|:|.:::|.::|:||||||||||||||||||:|||||:||||||||||||
  Fly    87 ILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLK 151

Worm   210 YIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSK 274
            ||||||||||||||||||||.|||||||||||||:.||:.|||||||||||||||||||||||||
  Fly   152 YIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 216

Worm   275 GYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLP 339
            |||||||:|||||||||||||||:|||||||||||.||.|:||||..||:||||:|||:||.|||
  Fly   217 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLP 281

Worm   340 HKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEM 404
            .||..|||:|:|.||..|||||.||||||||.||.:|:||||||||||||||||||.|.||.:.|
  Fly   282 FKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINM 346

Worm   405 EFDDLPKEKLKELIWEE 421
            |.||:.::.||.||:||
  Fly   347 ENDDISRDALKSLIFEE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mpk-1	NP_001022584.1	STKc_ERK1_2_like	90..422	CDD:270839	264/332 (80%)
mpk-1	NP_001022584.1	S_TKc	96..384	CDD:214567	233/287 (81%)
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	264/332 (80%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	233/287 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161685
Domainoid	1	1.000	497	1.000	Domainoid score	I177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37670
Inparanoid	1	1.050	572	1.000	Inparanoid score	I571
Isobase	1	0.950	-	0	Normalized mean entropy	S246
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309855at33208
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		oto20787
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1382
SonicParanoid	1	1.000	-	-		X259
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880