Protein Alignment gei-1 and cv-c

DIOPT Version :9

• Sequence 1: NP_497694.3
• Gene: gei-1 / 175436
• WormBaseID: WBGene00001559
• Length: 1510
• Species: Caenorhabditis elegans
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1742
• Identity: 431/1742 - (24%)
• Similarity: 671/1742 - (38%)
• Gaps: 499/1742 - (28%)

 Worm    47 KQQRKSLVIEPD-------ISLILAAGQNQSSSSDDDDTKVQIDSNTLPQNRRKYAGRRNMKK-- 102
            :||:..||::|:       .|..|..|:|::|                |..:...|..|.:..
  Fly   831 QQQQNGLVLKPEKHATIPLQSFYLDCGRNEAS----------------PATKSNVAYMRTLSAPN 879

 Worm   103 -RFYSTSNLKGNEDENDENSSKQIGTKSLSVRDLNG--DNI----------DFNNRDSVKKWT-- 152
             .|.|.................|...|||:...|||  |.|          :|.:...:::..
  Fly   880 GGFASGGGGGAARGSGAPALPPQSQRKSLACPPLNGQADTITPTPATHKLTNFQSALKIEEMAAA 944

 Worm   153 ---------SQIFAELESIPSSRR-----GSMEVTRAMTNP---PPELMINLA-----PTLAPPS 195
                     ||:...:|.:.|.|:     |.|| |...:.|   |..:.||.|     ..:.||.
  Fly   945 KGTAMATGESQLATTIEDLKSRRQRQLSGGDME-TMLASQPMSMPKRVGINHAVLTSRNAITPPP 1008

 Worm   196 PMKRKRFPVFDEQEAGFQPIAPVPSPRRQQEDVVGPTFLRDLLTASCSRSPCSESNYS------- 253
            .          ...:..|..|.|.|.:........|.:|.| :|...|.|....|..|
  Fly  1009 A----------SASSASQSAASVHSAKGSSSAGTTPGYLVD-VTKKGSTSTIWTSEESILRSVGA 1062

 Worm   254 ---DRLATSDTATTQKAS--------------------------------RASSFEW----LENS 279
               |..:||.::..::|:                                :..|..|    |::.
  Fly  1063 VDEDNNSTSSSSACEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHH 1127

 Worm   280 GHGKYEQCSSDEADRE-VASIEMVK----------------------------------QTEVLQ 309
            .|..:.:|:....|.| |:|:|.::                                  |.::|.
  Fly  1128 HHHHHRKCTGSAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLEVLSQCGSGGEANESQDDMLD 1192

 Worm   310 RKKTIEDLEESVNEL-----------QSLGNGSWFPHP---------PPPPAEARDQIYES---- 350
            .:|......:..:|:           .:.|.|.....|         |||....|.|...|
  Fly  1193 EEKDKMSKSQDYDEIWDCDCTDGDASSASGGGGVTATPVILRRKYTAPPPILVPRTQRSHSLDHY 1257

 Worm   351 ------------LPASFRNRKSEN--------RKNAVGSVYDNAAISS----------KPSSSET 385
                        ||......||:.        |:....|:...:|.::          .|||:..
  Fly  1258 HSPQPLVHPRKVLPIHHHALKSKERGQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSASL 1322

 Worm   386 TSFSQQKPIIDRKPFSLENLPMVQRLTELSAAKKNADSKNEVAKRSNTFS-LQLAERDAVDACSW 449
            .|.......|........:.||:.:..|:|....|.::::...:.|.:.| ..|||.:||:||.|
  Fly  1323 HSGLGDSGGIQELCTKSNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKW 1387

 Worm   450 LRKAGFSKYADQFEEGKLPI---VASKDPTLLEAD-LRALNRRIDVLNRCHTMKVD-----SVPM 505
            ||.|||.:||..:|:.:.||   ..:||.|.||.| |::|.||:.|||||.||::|     ..|.
  Fly  1388 LRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQ 1452

 Worm   506 RRRINNEFPRLDPMKIDDNSGYSSDSWRYGSVGGSHHSNTWSRPSGSDHHVYGGSLARMPNSTSS 570
            ::.           :.||.:...|:.|.:     ..|...|||.         |.:..
  Fly  1453 QKE-----------ESDDENFALSEHWTF-----QPHIRRWSRI---------GEMGL------- 1485

 Worm   571 AWHHQMADPTRDSRKVLRTDWYDAQNTPPRGRNNDVLETASSAAC------VNELNS-------- 621
                ::..|...|..|.:|:....:::|.|...:....|..:..|      .|:.:|
  Fly  1486 ----ELPPPGLLSLNVEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSG 1546

 Worm   622 KLQRSQSERIKDRARAIMKKMDLRSTNKRPKETR----------------GRPAPMNIGDPVLVS 670
            :|:||.||||||:|:|::::::...:.:|.::.|                |:.:.:...|.|
  Fly  1547 RLRRSGSERIKDQAKALLRRVESIKSRRRKRQNRENVVISGPTVLDLSQFGQRSSLRKPDAV--- 1608

 Worm   671 YDTPKNSIRSHHIDRPSILPERGRQLYPTSPY-----QAPSRSKSIAQNNRRGGLVFITPTSPNS 730
            |.||.:         ||.|..  ...:|.:|:     :.||.|.:....||....  .|||:|.|
  Fly  1609 YSTPPS---------PSALSP--MHTFPKAPFFGNDLKVPSHSDNFLSPNRSSPK--RTPTTPRS 1660

 Worm   731 LDTS-------------FGYSDTNSSVVSSHRSNGESRRRELSMPPPSRHRVQMNGPSYPVMDGT 782
            :.||             .|.||.:||..|.  |...|...:||:..||:.|
  Fly  1661 MRTSPLHFFSSPMSQLKEGKSDDSSSYYSD--SQESSTGGKLSLRKPSKAR-------------- 1709

 Worm   783 LRRREIMPFDSYLYAGNPKMLERYDKTYESPRNLIPDRMYDDL---DDLPLPKSTKTTNSNSTSN 844
                              :.|:|..|.             ||:   .|....:..|....::.||
  Fly  1710 ------------------RFLQRTGKV-------------DDIGAHSDSECHQGRKLLIKDANSN 1743

 Worm   845 SNSLDNKKTDNISMFNDGYYTHEIKTALPRHHNILTTVKPENLKVNTEKIDIISSSDEPIGRTAL 909
            :..:..||                          ||.....||..:.:|.|...||
  Fly  1744 TTEVKVKK--------------------------LTRGGSLNLGKDPKKRDGFRSS--------- 1773

 Worm   910 TKRSDSGLGSSLSRSPSGPHTQRIRQSLLPYSNATSSSAS-AYSCCSWGSSTKLLDEQQP----- 968
                     |..|||.|....:....:    :.||::..| ......|.|...   |::|
  Fly  1774 ---------SFRSRSTSRKEAKNDEDT----AGATTNGGSKRQPVVRWHSFQM---EERPNMIFR 1822

 Worm   969 -FFTDMVE-----------LARSIDSLNLIEMTRLRKTAFLRLSSILERNIEGKGVGLVDPDQEE 1021
             .|:..:|           .|.|...|.:|     ||.|.:.|:..:||               .
  Fly  1823 KCFSKKIEPLQEDAGGMPFAAMSAGQLQII-----RKLALVTLTGHMER---------------Y 1867

 Worm  1022 LPSKHV---WSVQRLIKRMKINDGQKREKDVDGDGAVFGVGLDVIFNRTGYFLPRPILEVMKFLR 1083
            .||...   |.:.:.||::|:.|.:        |..||||.|.:|..|:|..||..:....::|:
  Fly  1868 CPSHRSGWNWELPKFIKKIKMPDYK--------DKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQ 1924

 Worm  1084 NIAPETVGIFRKNGVKSRIAELRSIIE---SYSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLP 1145
            ..|.:.||||||:|.||||.:||..||   |.:...|||      |..|.:||||:||||||:||
  Fly  1925 LNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVF------DLQQAYDVADMLKQYFRELP 1983

 Worm  1146 EPLMTVKMSEVFANICSVVPDVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQ 1210
            |.|:|.||||.|..|...:|...|:.|:|.|:|||||||||.|..||.||..|:.|||.|.||:.
  Fly  1984 ESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSN 2048

 Worm  1211 NLSVCFTPSLFQLGASRLDKVTPGNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMV 1275
            ||.||...|:|....|........:.|.|..| :|:|..||:.||:|...||:.:||:.:.::..
  Fly  2049 NLGVCLAQSIFHSSISTGSASVSASPRRKGKG-SGMPDMKELAEAKASHECLSFMIEHYKQIYTA 2112

 Worm  1276 PDGLDDSMD---AEDDNP-NLTELG----LKGPRSFLVDRVIDLIRDHSDQWKNWTIEGSFR--G 1330
            ........:   .|:..| .|..||    ....|.:|.:.....|::..::.:.|....|..  .
  Fly  2113 AKEKLSKCNFSYMEESKPLPLEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSS 2177

 Worm  1331 IEISSKRPSDSHPLKTFRVWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLEYVSAPDTDIHQYV 1395
            ::|:.|:..|.|||:.:|....:...||.|:..::|:|.:||::::..:.::.:. ..|:|:||.
  Fly  2178 VDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLD-DRTEIYQYA 2241

 Worm  1396 VNETIGHPTKDCHVARFHSSGLTEIRGACAIAERSVKCTEDQ-LLGGVSATIFDQRFLIEPVSGG 1459
            ::   |..|.|..|.|...:.|.  ||||.|.|.|:...:.: |.|.|...:...|:||||...|
  Fly  2242 LD---GQLTTDFCVLRSWQTDLP--RGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSG 2301

 Worm  1460 QSRVNYIARVDLKGRSLQWYNKSFGSIMCRHLDRLRESF-HLGDKGGPETNV 1510
            :|||.::||||:||::.:||||::|.|...:|.|:|.:| |:.|  |||:.|
  Fly  2302 RSRVMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHVAD--GPESKV 2351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gei-1	NP_497694.3	SAM_superfamily	444..499	CDD:387673	30/58 (52%)
		RhoGAP_DLC1	1052..1279	CDD:239840	102/229 (45%)
		SRPBCC	1302..1501	CDD:387369	64/202 (32%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	30/58 (52%)
		RhoGAP_DLC1	1893..2116	CDD:239840	102/229 (45%)
		SRPBCC	2148..2343	CDD:301327	63/200 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I3278
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4702
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		oto20818
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	LDO	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890