DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pef-1 and rdgC

DIOPT Version :9

Sequence 1:	NP_741091.1	Gene:	pef-1 / 175257	WormBaseID:	WBGene00003969	Length:	707	Species:	Caenorhabditis elegans
Sequence 2:	NP_536738.3	Gene:	rdgC / 40224	FlyBaseID:	FBgn0265959	Length:	746	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	282/707 - (39%)
Similarity:	410/707 - (57%)	Gaps:	51/707 - (7%)

- Green bases have known domain annotations that are detailed below.

Worm     9 RQNPSTELKKSTRATTTTTSSSQRNNYNDNNQNTSSSSGNKKESSSSSKQHSSKKSKKSNSKKNR 73
            |::.|.|...|.|::......:.......|.|..||::.....:||..:....:...|...|..|
  Fly    16 RRSSSVEDASSCRSSEIERVGASMQTLGPNGQPQSSAAQTSTRASSLLQLFQRRGWCKHFRKPLR 80

Worm    74 SPS-PQPQLTIKSAILIQKWYRRCEARLEARRRATWQIFTALEYAGEQDQLKLYDFFADVIRAMA 137
            ..| .:.:.||::||.|||||||.:||.|.:||..||||..||||.||||.:||.||.|:|:.|.
  Fly    81 GMSASRAEKTIRAAIFIQKWYRRHQARREMQRRCNWQIFQNLEYASEQDQAELYKFFNDLIKHMP 145

Worm   138 EENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDK 202
            :..|:.....|  |..:|.|..  |..|::..|:.|...:|                   ||:.|
  Fly   146 QAAGRKNQYQG--SAHVSVLDD--KDDLVEEFGDIVNAKIE-------------------LPIRK 187

Worm   203 PQVAKMIEAF--KVNKVLHPKYVLMILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLC 265
            ..:..:|:.|  |....||||||.:||.||.|..|.:|::|.:||::|.|||:|||||||.|||.
  Fly   188 NHIDLLIDVFRKKRGNRLHPKYVALILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLL 252

Worm   266 IILYKNGYPSVDNPYIFNGDFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFI 330
            ::|:|||.||..|||:|||||||||.:.:|||.:|.:|.:..|.:::||||||||.:||.|||||
  Fly   253 VVLHKNGLPSSSNPYVFNGDFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFI 317

Worm   331 KELSTKYKDLSTPITRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRP 395
            :|:.:||......|...:::|:.|||:.::::..:.:||||.||.|.:..:..|.|.::.|:|||
  Fly   318 REVESKYPRNHKRILAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRP 382

Worm   396 PVNKGMESEKENSAVNVDEWKQMLDIMWSDPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRL 460
            |:..|...:|       .||:|:.|||||||:...||.||..||.|.:||.|:|.:||::|....
  Fly   383 PLTDGEPLDK-------TEWQQIFDIMWSDPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSY 440

Worm   461 LVRSHECKFEGYEFSHNNTCLTVFSASNYYETGSNRGAYVKFIGKSKQPHFVQYM--ASKTHRKS 523
            ::||||||..|:||.|:|..:|:|||||||..|||:|||:: :.....||||||:  ||:|.|.|
  Fly   441 VIRSHECKPNGHEFMHDNKIITIFSASNYYAIGSNKGAYIR-LNNQLMPHFVQYISAASQTKRLS 504

Worm   524 TLRERLGVVEESAVKELKEKLSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIAL 588
             .::|:|:||.||:|||..::.....:|:.||...|.:.||.:.|..|...:|.:|.|.|||..|
  Fly   505 -FKQRMGIVESSALKELAVRMRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLL 568

Worm   589 APKVATLSEDGKYVMYKEDRRIAQVGGTHAQEKD---IVESLYRHKSTLETLFRFMDKDNSGQVS 650
            ..|:|. ..|.:.|.|.....:.........|.|   ::::||.:|::|..:|..:|.||||:::
  Fly   569 RDKLAP-GTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDALYANKASLVAIFNIIDADNSGEIT 632

Worm   651 MKEFIDACEVL-----GKYTKRPLQTDYISQIAESIDFNKDGFIDLNELLEAFRLVD 702
            :.||..|.::|     |.|:|..:     .:....:|.|.||.:||||.||||||.|
  Fly   633 LDEFETAIDLLVAHMPGAYSKAEM-----LEKCRMMDLNGDGKVDLNEFLEAFRLSD 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pef-1	NP_741091.1	MPP_RdgC	199..515	CDD:277364	152/317 (48%)
		PP2Ac	218..514	CDD:197547	146/295 (49%)
		EFh	634..699	CDD:238008	25/69 (36%)
		EF-hand_7	634..698	CDD:290234	24/68 (35%)
rdgC	NP_536738.3	IQ	89..111	CDD:197470	14/21 (67%)
		MPP_RdgC	184..494	CDD:277364	152/317 (48%)
		EFh	616..681	CDD:238008	25/69 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158871
Domainoid	1	1.000	242	1.000	Domainoid score	I1240
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I760
Isobase	1	0.950	-	0	Normalized mean entropy	S3051
OMA	1	1.010	-	-		QHG59402
OrthoDB	1	1.010	-	-		D215218at33208
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	1	1.000	-	-		oto20679
orthoMCL	1	0.900	-	-		OOG6_105509
Panther	1	1.100	-	-	LDO	PTHR45668
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3052
SonicParanoid	1	1.000	-	-		X2939
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.890