DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mpo and cysu

DIOPT Version :9

Sequence 1:	NP_034954.2	Gene:	Mpo / 17523	MGIID:	97137	Length:	718	Species:	Mus musculus
Sequence 2:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	258/800 - (32%)
Similarity:	380/800 - (47%)	Gaps:	163/800 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 LLLALAGLLAPL-----AMLQTSNGATPALL--GEVENSVVLSCMEEAKQLVDRAYKERRESIKR 60
            |||:||.:....     ..|||::|:..|||  |...:||               |.......:.
  Fly     6 LLLSLAAVAHAQYHQFGEQLQTAHGSDCALLLAGPGRSSV---------------YDYNVNLFRG 55

Mouse    61 SLQSGSASPTELLFYFKQPVAGTRTAVRAADYL------HVALDLLKRKLQPL--WPRPFNVTDV 117
            :|...:..|...:.|         .|:.|| ||      |||        ||.  | :|   .::
  Fly    56 TLNPYNNGPGTCITY---------DAINAA-YLDARKRIHVA--------QPKSDW-KP---EEL 98

Mouse   118 LTPAQLNLLSVS------SGCAYQD--------------VRVTCPP--------NDKYRTITGHC 154
            .|..:| ||.:|      .|.:|::              :|..|||        ..|||...|.|
  Fly    99 ATVGEL-LLDISIQLARTYGLSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLC 162

Mouse   155 NNRRSPTLGASNRAFVRWLPAEYEDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTKD 219
            ||...||.||:|..|.|.:...|.||::     .|.::..|..:|.:|.||..:  .|:|.. .|
  Fly   163 NNIEHPTWGAANAPFQRLIGPLYSDGIN-----APRISVTGRDLPFSRVVSRTM--HPDDGF-HD 219

Mouse   220 QERALMFMQWGQFLDHDITLTPEPATRFSFFTGLNCETSC------LQQPPCFPLKIPPND--PR 276
            ....:|.:.||||:|||.|||..|....:    .|....|      |:.|.|..::||.:|  .|
  Fly   220 HAGTVMVIAWGQFMDHDFTLTGTPLDPIN----RNDPEECCKRPLHLKHPYCNEIRIPDDDYFYR 280

Mouse   277 IKNQKDCIPFFRSCPA----CTRNNITIRNQINALTSFVDASGVYGSEDPLARKLRNLTNQLGLL 337
            :.|.| ||.|.|..|:    |   .:..|.|.|.||..:||:.|||.::..|||||  |...||:
  Fly   281 LFNVK-CIDFVRGFPSPRPGC---KLGSRQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLM 339

Mouse   338 AINTRFQDNG-RALMPFD-SLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRL 400
            .:|..||:.| :.|:|.. .:.|:.|...|:|  :.||..|::|.:|...||.||||..||||||
  Fly   340 RMNPVFQEYGLKDLLPLKLDIPDEGCTRPNKS--MYCFEGGEIRVNEQLVLTCMHTLMAREHNRL 402

Mouse   401 ATQLKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKY---LPQ---YRSYNDS 459
            ||.|.::|..|:.|.|:||||:|..|:||.:|:.::||::||...|:|:   |.:   :..|:.:
  Fly   403 ATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDST 467

Mouse   460 VDPRIANVFTN-AFRYGHTLIQPFMFRLNNQYRPTGPNPRVPLSKVFFASWR----------VVL 513
            |:|.|.:.|.. |||:||:|:...:.|.:..::             |.||.|          :..
  Fly   468 VNPGIIDSFAGAAFRFGHSLLPTAVERWSKAHK-------------FIASKRLSDLIRRPYDLYR 519

Mouse   514 EGGIDPILRGLMATPAKLNRQNQIVVDEIRERLF-EQVMRIGLDLPALNMQRSRDHGLPGYNAWR 577
            .|.:|....|||...|:  ..:..:..|:...|| ::..|.|:||.:.||||.|:.|:|||..:|
  Fly   520 AGVLDEYFMGLMNQVAQ--AMDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFR 582

Mouse   578 RFCGLPQPSTVGELGTVLKNLELARKLMAQYGT----PNNIDIWMGGVSEPLEPNGRVGQLLACL 638
            :|||||..:|..|:...:.|     :.:.:||:    |.:||:|.|||||...|...:|...||:
  Fly   583 KFCGLPTSNTWDEMYGSMPN-----ETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACV 642

Mouse   639 IGTQFRKLRDGDRFWWE---NPGVFSKQQRQALASISLPRIICDNTG-ITTVSKNNIFMSNTYPR 699
            |.||...||.|||||:|   .|..|:.:|.|.:....|.|:|||||. |.||....:.:.:....
  Fly   643 IATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEIN 707

Mouse   700 DFVSCNT--LPKLNLTSWKE 717
            ..|.|.:  :|.::||.|.:
  Fly   708 PRVPCKSGIIPSIDLTKWAD 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mpo	NP_034954.2	An_peroxidase	147..685	CDD:281139	207/577 (36%)
Mpo	NP_034954.2	myeloperoxidase_like	289..702	CDD:188656	157/444 (35%)
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	206/576 (36%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	149/405 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.800