DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment H10E21.5 and rnf150a

DIOPT Version :9

Sequence 1:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans
Sequence 2:	NP_001139044.1	Gene:	rnf150a / 559804	ZFINID:	ZDB-GENE-060213-1	Length:	418	Species:	Danio rerio

Alignment Length:	396	Identity:	120/396 - (30%)
Similarity:	174/396 - (43%)	Gaps:	114/396 - (28%)

- Green bases have known domain annotations that are detailed below.

Worm    30 VKLQCIDSEEVYGTLQTELTFSNKDGGGSTFLP-AYTDLCAPDMKFDDSQRVFFCKNCIQNCLSR 93
            |.|.|:|           .|.:.|:...:.|:. .|.|....::|.|.|:           |...
Zfish    24 VHLLCLD-----------FTVAEKEEWYTAFVNITYLDPVTSEIKTDRSE-----------CGRY 66

Worm    94 VETAPKN-----ILIVADVKA---------PNNRVSWFH-VQTPVSNIRESGKQC---------- 133
            .|.:||.     :.:..|.:|         |:..:.|.. :.......||..:..
Zfish    67 GEHSPKRDARGFVFMPQDRQACDGNTRFPLPHPSIPWIALIAKGNCTFREKIRHAAALNASAVVI 131

Worm   134 -NVENSN----------------AMQSPEETSTDAL---------------------RSFSKTSV 160
             ||.:||                |:..||....:.:                     :..|:|||
Zfish   132 FNVGSSNSNDTITMPHHGTGDVVAIMIPEPKGREIMALLEKNITVAMHISIGTRNLQKYVSRTSV 196

Worm   161 LFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQELQS 225
            :|||||||:||:||||||||||:||||||:|:||.||||.:||:||::::...||..| .:|..|
Zfish   197 VFVSISFIVLMIISLAWLVFYYIQRFRYANARDRSQRRLGDAAKKAISKLQVRTIRKG-DKETDS 260

Worm   226 D---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGY------WNDI 281
            |   ||||::.|:..||:|:|||:|::|::|:||||.:||||||||.:|||..|.      .:|.
Zfish   261 DFDNCAVCIEDYKPNDVVRILPCRHVFHRNCVDPWLQDHRTCPMCKMNILKALGIPPNTDCSDDA 325

Worm   282 RNDIQMPTNSRGIADDFTIRLELGE------------------QEHQAPSADVISPEANSDTSDS 328
            ..|.:..:....||......:.:||                  ||..:..||..||...|.....
Zfish   326 PPDYETSSGQPSIAVTGASEVSVGESSLVLDQPLRITGLSHDYQEMNSVPADAESPHIASSEQHQ 390

Worm   329 QGFSFD 334
            ...|.|
Zfish   391 PSMSND 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	89/222 (40%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	28/49 (57%)
rnf150a	NP_001139044.1	PA_GRAIL_like	45..180	CDD:239037	22/145 (15%)
		UPF0233	<194..>219	CDD:299753	21/24 (88%)
		zf-RING_2	263..306	CDD:290367	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161007950
Domainoid	1	1.000	82	1.000	Domainoid score	I5903
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm12529
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730