DRSC/TRiP Functional Genomics Resources

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Protein Alignment H10E21.5 and gol

DIOPT Version :9

Sequence 1:NP_497129.1 Gene:H10E21.5 / 175169 WormBaseID:WBGene00019185 Length:473 Species:Caenorhabditis elegans
Sequence 2:NP_001163300.1 Gene:gol / 38006 FlyBaseID:FBgn0004919 Length:601 Species:Drosophila melanogaster


Alignment Length:348 Identity:119/348 - (34%)
Similarity:161/348 - (46%) Gaps:86/348 - (24%)


- Green bases have known domain annotations that are detailed below.


 Worm   152 LRSFSKTSVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTIT 216
            :.|.::|||||||||||:||:|||.||:|||:|||||..|||:..|.|.:..:||:.:|||.|..
  Fly   227 ISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGK 291

 Worm   217 PGMTQELQSD-CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGY--- 277
            ....::|.|| ||:|::.|:..|.||:|||||.:||:||||||:|||||||||.|:||.:||   
  Fly   292 FSDEKDLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYGYVFL 356

 Worm   278 ------------------WNDIRNDIQMPTNSRGIADDFTIRLEL------GEQEHQAP------ 312
                              ..:.|::......||....||.....|      |.:|...|      
  Fly   357 GSEESILEYQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDSGCVVGAREMLFPCRIPER 421

 Worm   313 ---------SADVISPEANSDTSDSQGF-SFDNSE-------------HHHSESFG--YGT---- 348
                     :.|.:|..:|. ..:.||. |..|.|             |..|.|..  |.|    
  Fly   422 SQSSLSLRQARDWVSLMSNK-LEEQQGLRSMRNDEMQQQLLSARESARHRRSRSADGRYSTGCFG 485

 Worm   349 ----------SSTVPPQL-----VLNASNAKSFVMPLSSRGVSQGPQASRD-FRSARAPR----- 392
                      ||...|||     .:..||:...:..|:....:|..|..|: |..||..|     
  Fly   486 GRQRQPSVLVSSLGQPQLHSEVAQMQRSNSSQALKHLTDAAHAQSRQRQRESFDFARTRRRFMRR 550

 Worm   393 -DHRASLHELPRPQTSAASQGQI 414
             ....||..|||...::|:..|:
  Fly   551 ESDEISLRSLPRRGATSAAHRQL 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
H10E21.5NP_497129.1 HRD1 <150..325 CDD:227568 87/215 (40%)
RING-H2_GRAIL 226..273 CDD:319582 31/47 (66%)
golNP_001163300.1 PA_GRAIL_like 73..217 CDD:239037
UPF0233 226..>258 CDD:299753 21/30 (70%)
zf-RING_2 301..344 CDD:290367 28/42 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160158743
Domainoid 1 1.000 81 1.000 Domainoid score I5497
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3321
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000832
OrthoInspector 1 1.000 - - oto17963
orthoMCL 1 0.900 - - OOG6_107948
Panther 1 1.100 - - LDO PTHR22765
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3602
SonicParanoid 1 1.000 - - X295
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.780

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