Protein Alignment DLX3 and HHEX

DIOPT Version :10

• Sequence 1: NP_005211.1
• Gene: DLX3 / 1747
• HGNCID: 2916
• Length: 287
• Species: Homo sapiens
• Sequence 2: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 1252
• Identity: 223/1252 - (17%)
• Similarity: 380/1252 - (30%)
• Gaps: 418/1252 - (33%)

Human    31 PGKKKPQNKEMKKKPSDIKKSSASALKKETDASKTMETVSSSSSAKSGQIKSSTVKVNKCAAKSG 95
            ||...|...||.:|..  ::.:|..|.:|       .......:||:.|......|..:...|..
  Fly    11 PGGNNPWEAEMARKQR--REQTARELSQE-------RREQERRAAKARQRAEKEAKRQQKKKKKK 66

Human    96 KKSLEAKKSGNIKNKDSNKPVTVPANSEIKASSEDKATGKSAEESPSGTLEATEKEPVNKESEEM 160
            |:.||.|.|                      :|..|......:|     |..||..|:.::|:
  Fly    67 KQQLERKAS----------------------ASRSKQRRSKLDE-----LRDTEPPPIVRKSK-- 102

Human   161 SVVFISNLPNKGYSTEEIYNLAKPFGALKDILVL------------------------------- 194
                 :.|....|.:|....:........||.||
  Fly   103 -----AKLEESDYDSEAKRRMQHQLAFNSDIFVLNQLVLGVQFYGNFEREMWEAVERNRNEENRR 162

Human   195 ----SSHKKAYIEINK--KSADSMVKFY----------------TCFPI--------SMDGNQLS 229
                |.|.|..|..::  ::.|..||||                ||:.:        ..|.:..|
  Fly   163 NGKTSRHCKTVILPDRLLEAVDKRVKFYAKHGPNKNRLLPLHTQTCYVVHDNIEITNPGDSSVYS 227

Human   230 ISMAPEHVDLKDEEALFTTLIQENDPEANIDK----IYNRFVHL-------DNLPEDGLQCVLCV 283
            |........|:.|:||...|.|.......:.|    .::.::.|       .|.|...|..:|..
  Fly   228 ILTDAPIYKLEIEDALEDKLKQSGADAGAVRKRRTHCHHGYIKLKSVEYIKPNNPAPALDRILAF 292

Human   284 GHQFGKVDRYMFMSNKNKVILQLESPESALSMYNFLKQNPQNIGEHVLTCTLSPKTDSE-----V 343
            |.:.|.......:.|             .::..|.|.::.          ||..:.|.|     .
  Fly   293 GAEPGPSGLGPKLPN-------------GMAKVNSLSESD----------TLEDEDDDEEEEDDA 334

Human   344 QRKNDLELGKGSTFSPDLKNSPVDESEVQT---------------------AADSSSVKPSEVEE 387
            :..:|...|:|:.....||..  |...|:|                     :..:||..|...|.
  Fly   335 EEDDDTGAGRGANRFAKLKYR--DSIMVKTSNGVYGKRPQSQLLLANAGVPSTSTSSTSPPSSEY 397

Human   388 E----TTSNIGTETSVHQEELGKEEPKQALCESDFAIQTL--------------ELEAQGAEVSI 434
            :    |..|.....||.:...|.|.|.......|:.|.|:              |.|....::|:
  Fly   398 DYAYITAINTHQPLSVMRSAGGDEAPVSTTVLPDYCITTICCPIEVHEGYYSDDESEGTDHKLSM 462

Human   435 EIPLVASTPANIELFSENIDESALNQQMYTS--DFEKEEAEVTNPETELAVSDSVFIEERNIKGI 497
            ........|..         ...|..|.:.|  ::..|..:..|.:..||...::|
  Fly   463 YRGQGGGGPGG---------SGKLRHQQHHSNAEYTTERRQYLNSKGFLAYFVNLF--------- 509

Human   498 IEDSPSETEDIFSGIVQPMVDAIAEVDKHETVS----EVLPSACNVTQAPGSYIEDEKVVSKKDI 558
             :|:.:...||      |..|..:...|...|.    |::|:.  ::..|...|  |.|..|:|:
  Fly   510 -QDTLAAELDI------PAEDLRSATWKGAVVYSGQWEIVPAI--LSPWPREAI--EWVHRKRDV 563

Human   559 AEKVILDEKEEDEFNVKETRMDLQVKT-----------EKAEKNEAIIFKEKLE-KIIAAIREKP 611
            ....:..:|    |......|..:||:           .|..:|.    ..:|| ||:....|:.
  Fly   564 KINPLTRQK----FQWPTQPMIQKVKSFGCHVIPSGYAPKQGQNR----HRQLEWKIVFPEAERY 620

Human   612 IESSVIKADPTKGVDQTSKPDETGKSSVLTVSNVYSSKSSIKATVVSSPKAKSTPSKTESHSTFP 676
            :||.:                 ||              :.||..:::....|          ||.
  Fly   621 LESCL-----------------TG--------------TQIKIYMITVLLLK----------TFV 644

Human   677 KPVLREQIKAEKKVSAKEFGLLKNTRSGL---AESNSKSKPTQ------IGVNRGCSGRISALQC 732
            :|.|...:..        || |::.|:.|   .|:|..:.|..      :........||.....
  Fly   645 EPTLTPGLSM--------FG-LEHLRAHLFWQCETNYAAWPEDYLGEALLRFLNALLDRIKTHTL 700

Human   733 KDSKVDYKDITKQSQETE-----------TKPPIMKRDDSNNKALALQNTKNSKSTTDRSSKSKE 786
            .|..:..:::.:...|..           |:.|:|      :..:||:|.|...:......|.:.
  Fly   701 PDYFLPARNLFENVPERVLVELHKRIFRITENPVM------HLLIALRNLKLPSARLAFYPKVRI 759

Human   787 EPLFTFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKEALKISPSPELNLKKKKGKTSVPHSVEGE 851
            :.|::     |:.:|..::.|||
  Fly   760 KRLYS-----FLVIDNPLKIVNP------------------------------------------ 777

Human   852 LSFVTLDEIGEEEDATVQALVTVDEVIDEEELNMEEMVKNSNSLLTLDELIDQDDCIPHSGPKDV 916
                    :..:||..:.|     |..||.|.|..|:...|.:.....|:        .|..|..
  Fly   778 --------MLRDEDENLAA-----EDSDENEANEREIAVGSMAYYHQQEV--------ESRRKRT 821

Human   917 TVLSMAEEQDLQQERLVTVDEIGEVEESADITFATL----NAKRD-------------KRDSIGF 964
            .::.....:.|::||.|..:....| ||.|:||..|    |.:|.             .|.|.||
  Fly   822 RIVRFLVAEQLKKERAVQPERRQSV-ESIDLTFLPLKHMENLRRQLIYGLFVEHFIEMARVSGGF 885

Human   965 ISSQMPEDPSTLVTVDEIQDDSSDFHLMTLDEVTEEDENSLADFNNLKEELNFVTVDEVGDEEDG 1029
            .:..     ..|:.:.:.:   ...:|:..||..||....|.....|::||...:....
  Fly   886 RALN-----QALIYLRQAE---RLCNLLADDEGIEEARQFLTQIYGLRQELARASAKGA------ 936

Human  1030 DNDSKVELARGKIEHHTDKKGNRKRRAVDPKKSKLDSFSQVGPGSETVTQKDLKTMPERHLAVDD 1094
              |......|........::..|::.:|..:.||..:::.|.|.:.:...| .:..|:|..:.||
  Fly   937 --DRPALPKRTSTTERQQQQQQRRKVSVARQNSKRTTYTNVRPQTTSGGAK-RQQQPQRFFSPDD 998

Human  1095 AELKDSEPDEKRRKTQD 1111
            .:..:.|.:|:..:.:|
  Fly   999 EDEDEEEEEEEEHEWED 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DLX3	NP_005211.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..39		3/7 (43%)
		DLL_N	27..107	CDD:463567	19/75 (25%)
		COG5576	<109..232	CDD:227863	29/183 (16%)
		homeobox	129..188		10/58 (17%)
		Homeodomain	130..186	CDD:459649	10/55 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..287		27/128 (21%)
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	11/50 (22%)