Protein Alignment DLX3 and Hmx

DIOPT Version :10

• Sequence 1: NP_005211.1
• Gene: DLX3 / 1747
• HGNCID: 2916
• Length: 287
• Species: Homo sapiens
• Sequence 2: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 82/280 - (29%)
• Similarity: 111/280 - (39%)
• Gaps: 85/280 - (30%)

Human    30 PTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQ 94
            ||.|.||.:..|               |.::   |:|...:|.|..|        .|...:|..:
  Fly   397 PTTPTSSSSSGG---------------GSSL---THHPHPHLTGSHG--------GYLLPSSSNE 435

Human    95 YGAYREQPLPAQDPV---SVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLAL 156
            .....|:.:...|..   |....|..:     |..|:.:|.||::|..|:..|:..|...:||:.
  Fly   436 SDEEGEEIIEEDDGTDGPSDSSSPHGD-----GNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSS 495

Human   157 PERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNS------------ 209
            .|||.|||.|.||:|||||||||||:|:|:     ::..|....|..:||..:
  Fly   496 SERAGLAASLRLTETQVKIWFQNRRNKWKR-----QLAAELEAANMANMAHAAQRLVRVPVLYHD 555

Human   210 -------PPSPALWDTSSHSTP----APARSQLPPPLPYSA----------SPSYLDDPTNSWYH 253
                   ||.|      .|..|    |.||:..||..|.|:          :|..|..|.||..|
  Fly   556 GTTAGFVPPPP------PHHHPMQYYAAARNTSPPRPPLSSLVXGVGCLATAPMSLLKPPNSMAH 614

Human   254 AQNLSGPHLQQQPPQPATLH 273
            .     ||  .|||.||.||
  Fly   615 P-----PH--PQPPPPAPLH 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DLX3	NP_005211.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..39		5/8 (63%)
		DLL_N	27..107	CDD:463567	15/76 (20%)
		COG5576	<109..232	CDD:227863	47/148 (32%)
		homeobox	129..188		31/58 (53%)
		Homeodomain	130..186	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..287		31/112 (28%)
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	30/55 (55%)