DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdc-48.1 and TER94

DIOPT Version :9

Sequence 1:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	630/820 - (76%)
Similarity:	722/820 - (88%)	Gaps:	15/820 - (1%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MASVPTHQSEKEK------KNDELSTAILKDKVKPNRLIVDQSEQDDNSVIAVSQAKMDELGLFR 59
            |....:.|.||.|      |.::|:|||||.|.:||||||::::.|||||:::||||||||.|||
  Fly    11 MRGYHSEQDEKMKPKDSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFR 75

Worm    60 GDAVILKGKKRKESVAIIVSDESCPNEKVRMNRVVRNNLRIRLGDVVSITPAPNLSYGTRIHVLP 124
            ||.||||||:|||:|.|::||::||:||:||||||||||.:.|.||||:...|::.||.|:.:||
  Fly    76 GDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILP 140

Worm   125 IDDTIEGLTGNLFDVFLKPYFLEAYRPLHKGDIFTVQAAMRTVEFKVVETEPAPACIVSPDTMIH 189
            ||::.||:|||||:::|||||||||||:|.||.|.|:||||.:|||||.|:|.|.|||:|:|:|.
  Fly   141 IDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIF 205

Worm   190 YEGDPIKREEEEESMNDIGYDDLGGVRKQLAQIKEMVELPLRHPQLFKAIGIKPPRGILLFGPPG 254
            .:||||||||||||:|.:||||:||.||||||||||||||||||.||||||:|||||||::||||
  Fly   206 CDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPG 270

Worm   255 TGKTLIARAVANETGSFFFLINGPEVMSKMSGESESNLRKAFEECEKNQPAILFIDEIDAIAPKR 319
            |||||||||||||||:|||||||||:|||::|||||||||||||.|||.|||:||||||||||||
  Fly   271 TGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKR 335

Worm   320 EKTNGEVERRIVSQLLTLMDGVKGRSNLVVIAATNRPNSIDGALRRFGRFDREIDIGIPDAVGRL 384
            :||:|||||||||||||||||:|..|:|:|:||||||||||.|||||||||||||||||||.|||
  Fly   336 DKTHGEVERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRL 400

Worm   385 EILRIHTKNMKLADDVDLEQIANECHGFVGADLASLCSEAALQQIREKMELIDLEDDQIDAEVLN 449
            |:||||||||||.|||||||||.|.||.|||||||||||||||||||||:|||||||:||||||.
  Fly   401 EVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLA 465

Worm   450 SLAVTMENFRFAQGKSSPSALREAVVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGM 514
            ||||||||||:|..|||||||||.|||.|||||:|||||::||:|||||||||||||:|:|||||
  Fly   466 SLAVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGM 530

Worm   515 QPSRGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCV 579
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||:|||||:|||||
  Fly   531 QPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCV 595

Worm   580 LFFDELDSIAKARGGGAGGDGGGASDRVINQVLTEMDGMNAKKNVFIIGATNRPDIIDPAVLRPG 644
            |||||||||||||||.. ||.|||:||||||:|||||||.||||||||||||||||||||:||||
  Fly   596 LFFDELDSIAKARGGNV-GDAGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPG 659

Worm   645 RLDQLIYIPLPDEASRHQILKASLRKTPLSKDLDLTFLAKNTVGFSGADLTEICQRACKLAIRES 709
            ||||||||||||:.||..||||:|||:||:|::|||::||.|.||||||||||||||||||||::
  Fly   660 RLDQLIYIPLPDDKSREAILKANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQA 724

Worm   710 IEKEIRIEKERQDRQARGEELMEDDAVDPVPEITRAHFEEAMKFARRSVTDNDIRKYEMFAQTLQ 774
            ||.|||.||||.:.|....::.||   |||||||.||||||||||||||:|||||||||||||||
  Fly   725 IEAEIRREKERAENQNSAMDMDED---DPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQ 786

Worm   775 QSRGFGNNFKFPGEQRGSDAPSAPVPAQD-----DDDLYN 809
            ||||||.||:|||:...:......:|...     |||||:
  Fly   787 QSRGFGQNFRFPGQTGNTSGSGNNLPVNSPGDNGDDDLYS 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513	54/80 (68%)
		CDC48	52..775	CDD:273521	584/722 (81%)
		CDC48_2	137..197	CDD:215011	39/59 (66%)
		AAA	247..376	CDD:278434	110/128 (86%)
		AAA	520..654	CDD:278434	122/133 (92%)
		Vps4_C	<727..771	CDD:286426	33/43 (77%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	597/743 (80%)
		CDC48_N	47..129	CDD:280513	54/81 (67%)
		CDC48_2	153..213	CDD:215011	39/59 (66%)
		AAA	263..392	CDD:278434	110/128 (86%)
		AAA	536..669	CDD:278434	122/133 (92%)
		Vps4_C	<741..783	CDD:286426	33/44 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158377
Domainoid	1	1.000	229	1.000	Domainoid score	I1399
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1264	1.000	Inparanoid score	I79
Isobase	1	0.950	-	0	Normalized mean entropy	S74
OMA	1	1.010	-	-		QHG60945
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		otm14364
orthoMCL	1	0.900	-	-		OOG6_100525
Panther	1	1.100	-	-	O	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R182
SonicParanoid	1	1.000	-	-		X1760
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790