DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kin-15 and btl

DIOPT Version :9

Sequence 1:	NP_741035.2	Gene:	kin-15 / 174498	WormBaseID:	WBGene00002199	Length:	488	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	342	Identity:	113/342 - (33%)
Similarity:	180/342 - (52%)	Gaps:	43/342 - (12%)

- Green bases have known domain annotations that are detailed below.

Worm   131 EF--DPRFEIDQAKLEISEDKLGSGFFGEVCYGLLSMRTSNTETDTLQKLSVAVKQSNDPTQENQ 193
            ||  |..:||.:.:|.:. ..||.|.||.|   :::.......:..|.:..||||...:...:..
  Fly   698 EFPLDSNWEIPRQQLSLG-SILGEGAFGRV---VMAEAEGLPRSPQLAETIVAVKMVKEEHTDTD 758

Worm   194 EKMIEDETKLMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLE-------EKKSI 251
            ...:..|.::|..||::.||:.::|..   |......:|||:...|:|..||:       :::|
  Fly   759 MASLVREMEVMKMIGKHINIINLLGCC---SQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRS- 819

Worm   252 FKDELVYEKNGYLLPKSIRRKTYMFNENEDDVIEESLDSLCTSDLLSFSYQIAEGMEYLASIPCV 316
                   :.:|||                ||....|...|...:|..|::|||.|||||||..|:
  Fly   820 -------DSDGYL----------------DDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCI 861

Worm   317 HRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYRITKGVGTPMPARWMAPEVMREGKCTEKSDV 381
            |||||.||||::....::||||||||..|...|||  |.....:|.:|||||.::|.|...:|||
  Fly   862 HRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYR--KNTNGRLPIKWMAPESLQEKKYDSQSDV 924

Worm   382 WSYGVSLYEMFSLGELPYSNV-SNSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRPSF 445
            |||||.|:|:.:.|:.||.:: |..:::.:::.|.::..|..|...:|..|:|.|:|::..||:|
  Fly   925 WSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTF 989

Worm   446 SKCVEFFEEHLSVSATN 462
            ::.||.|:..|..:::|
  Fly   990 AELVESFDGILQQASSN 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kin-15	NP_741035.2	STYKc	147..452	CDD:214568	104/312 (33%)
kin-15	NP_741035.2	PTKc	148..453	CDD:270623	104/312 (33%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	109/332 (33%)
		TyrKc	712..996	CDD:197581	105/316 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010