DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment T13H5.1 and Ptp36E

DIOPT Version :9

Sequence 1:	NP_001122640.1	Gene:	T13H5.1 / 174359	WormBaseID:	WBGene00011755	Length:	864	Species:	Caenorhabditis elegans
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	265/712 - (37%)
Similarity:	387/712 - (54%)	Gaps:	93/712 - (13%)

- Green bases have known domain annotations that are detailed below.

Worm   130 KPSKARKSKSVR--DAEPGLRSMLYGLSQKQEKEEAIAK-----KLAK-----------KMIIQE 176
            |..|.|...|.|  |.|           ::|.|..||..     ||:.           |:..::
  Fly    16 KTGKHRSRSSARYDDVE-----------KQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARD 69

Worm   177 E--KAMQAVPTSPVDASKFVAYVQERRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPD 239
            |  ...:.:|..|:|...|:.....|||..:|:|.|: .....:::|.||..:....:::|..|.
  Fly    70 ENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLEF-QTAAKVESNTCRHALKKNNLEKNQNPK 133

Worm   240 TLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNAEFWRMVWELGSNCIV 304
            .:|||||||:|.::.|.::|.|:|||||:|.|:..||:|||....:.:.| :|||||:...:.||
  Fly   134 CIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQA-YWRMVWQENISAIV 197

Worm   305 MLTKVFDFMRVMCLQYWP---LTKFQFREIEVETTEVKTYSHFVIRTFKLTRTT--PESIETRIV 364
            ||||.|||.:|||.||||   ....|:.:|.:.....:..::|.||||:|.:..  .|..:.|::
  Fly   198 MLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLI 262

Worm   365 KHFHFTEWELDSFPYISAFIELRRRVRQFM-----EKNPVEAPMVVHCSNGAGRSGAFLALDANL 424
            ..||:|||...|.|:.:|.:|.|||||..:     :::.:..|::||||:|.||||.::::||||
  Fly   263 LQFHYTEWYSHSCPFSNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANL 327

Worm   425 ELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ--PIEMHLLKERSSMYK 487
            ||.::....:.|.|.|.|..||..|:::||||.|||:.|.|.::|...  |:     .|.|...|
  Fly   328 ELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPV-----SELSDRLK 387

Worm   488 AKKNR----ELLETQETHENKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTL 548
            ||..|    ::.|.|..::.  :...||...|||||||||.:||.|||||:.||||:.||||.:.
  Fly   388 AKARRNSGTKMNEYQAEYDQ--ICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSF 450

Worm   549 HGESKDYT-YINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQ-RHYP 611
            .|.:  :| |||:|.|||:|:..|:||||||.:.|:..||:|:||..|..||.|....|| :.||
  Fly   451 QGNA--FTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYP 513

Worm   612 SFIHNKGK-ANYGP-FIVEIMNYHQYPAMTSHMVKVMKRPHQVPPMKVDPEGKGVSKLTFMISDI 674
            ||..||.| ..||| |.|..:....|..:.....|:.|:               :..||.|::.
  Fly   514 SFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKK---------------IVSLTEMMAG- 562

Worm   675 MATGAQNQQIDAEVRICCVIQVRMWPIENKVPLSTTGLIDVIKMARSWRKRAPDRPETKPTIVMS 739
                     :.|..|...:.|:..||:.:|||.||..|:.::.|...||.:.    :..|..|:|
  Fly   563 ---------VKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKV----DYGPVCVVS 614

Worm   740 HNGVSRVGVYIGANICIDQMDIDH-EVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYM 800
            .:|.||.|||..||.||:|: |.| |||||.|||.:|.:||||::...||||.||::||:.:
  Fly   615 PDGRSRAGVYCAANACIEQV-IQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
T13H5.1	NP_001122640.1	PTPc	206..465	CDD:214550	108/268 (40%)
		PTPc	233..465	CDD:238006	102/241 (42%)
		PTPc	517..797	CDD:214550	118/284 (42%)
		PTPc	528..796	CDD:304379	109/272 (40%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	102/243 (42%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	111/274 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165980
Domainoid	1	1.000	200	1.000	Domainoid score	I1765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I970
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48012
OrthoDB	1	1.010	-	-		D20096at33208
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	1	1.000	-	-		oto18701
orthoMCL	1	0.900	-	-		OOG6_121003
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810