DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Foxk1 and FoxK

DIOPT Version :9

Sequence 1:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	219/633 - (34%)
Similarity:	277/633 - (43%)	Gaps:	215/633 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    50 PPALPAEPGPGPVPSTVATATTTAPALVAAAAASVRQSPGPALARLEGREFEFLMRQPSVT-IGR 113
            |||..:.....  .|:..:|.|..|   :|.|||...|..|....|...: |.|....:|| |||
  Fly   117 PPATSSTTNSS--SSSTTSANTNNP---SANAASTLTSSSPPYGELRFNQ-EVLPITDAVTVIGR 175

Mouse   114 NSSQGSVDLSMGLSSFISRRHLQLSF--QEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTF 176
            |||...|..::..::.:||:|.|:.:  :...|:::||.|||:|||...|||....|:|||:|.|
  Fly   176 NSSTSLVHFNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDDFLQRRNVDPLRLPQRCYF 240

Mouse   177 RFPSTAIKIQFTS----------------------------------------------LYHKEE 195
            |||||.|:|:|.|                                              |:|.::
  Fly   241 RFPSTEIRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQ 305

Mouse   196 ---------------------------------APASPLRPLY---------------------- 205
                                             .|.:|..||:
  Fly   306 QPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGA 370

Mouse   206 ---------PQI-SPLKIHIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNV-- 258
                     |.| |||||.||:.:.:   ||..|||||||..||||||||..      |:||.
  Fly   371 AAHLIAGDGPGIYSPLKISIPKKEQK---SPYLSPTGTISAANSCPASPRQG------FIQNQPN 426

Mouse   259 ---------TSDLQLAAEFAAKAASEQQADASGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTL 314
                     |.||......|:...:|               |||||||||||||||:|.|:||||
  Fly   427 NYNNYGNNNTQDLFQTPSTASYNHNE---------------KPPYSYAQLIVQAISAAPDKQLTL 476

Mouse   315 SGIYAHITKHYPYYR-TADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQ 378
            ||||:.|.||||||| ..:||||||||||||||||||||.|||:||||||||||||.|.|||::.
  Fly   477 SGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDH 541

Mouse   379 AFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGSPIPHDPDLGSKL 443
            :::|||||....||.|:|  ..||||.||:|..              .|||.||:   .|:
  Fly   542 SYKKRRQRSSQGFRPPYG--MPRSAPVSPSHMD--------------NSRESSPL---QDI---- 583

Mouse   444 ASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSGHAIHVVQQAPTV 508
                   ..|||||||.      |::..|.::         |..|..||  :.|     ||....
  Fly   584 -------VLQSAPGSPG------MSLEQRAAD---------PEIIYNSQ--NAH-----QQQQQQ 619

Mouse   509 TMVRVVTTSANSANGYILASQGS----TGTSHDTAGTAVLDLGNEARG 552
            ...:...|.:|::|.|   |.||    |..|...|.......|:.|.|
  Fly   620 QQQQQQQTLSNNSNQY---SSGSPYYVTNQSSGVATPQTHVEGSAASG 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67		4/16 (25%)
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		173/450 (38%)
		FHA	<88..190	CDD:224630	44/150 (29%)
		FHA	96..189	CDD:238017	41/95 (43%)
		Forkhead	291..377	CDD:278670	72/86 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		13/43 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	39/82 (48%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	72/86 (84%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4491
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm42535
orthoMCL	1	0.900	-	-		OOG6_104629
Panther	1	1.100	-	-	LDO	PTHR45881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	1	1.000	-	-		X1668
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860