DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DLG4 and dlg1

DIOPT Version :9

Sequence 1:	XP_011522001.1	Gene:	DLG4 / 1742	HGNCID:	2903	Length:	797	Species:	Homo sapiens
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	302/707 - (42%)
Similarity:	405/707 - (57%)	Gaps:	129/707 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    26 LLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQVNAPELVHVAERNLS 90
            ::.:..|.||||||||.::||.:|.:..| ..|.:....|:.:    .......:.|.:|:....
  Fly   334 VIRIFKSRLFQALLDIQEFYELTLLDDSK-SIQQKTAETLQIA----TKWEKDGQAVKIADNQRM 393

Human    91 HLEAG---------------HGVVGHAHLSPFKANSPPVIVNTDTLEAPGYVNGTEGEMEYEEIT 140
            .:|:.               ......:..||.:.| |.....:.:......|||.:..: ||:|.
  Fly   394 RIESDTENAKEPTVEQQQKQQQAQQRSSRSPQQQN-PQQQQGSKSRSGSQTVNGDDSWL-YEDIQ 456

Human   141 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 205
            ||||||||||||||||||||||.|.||:|||:|.|||||.||||.:||.|:.||:|.|.:|.|::
  Fly   457 LERGNSGLGFSIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHAS 521

Human   206 AVEALKEAGSIVRLYVMRRKPPA-------------------EKVMEIKLIKGPKGLGFSIAGGV 251
            ||:|||:||::|:|:|.|::..|                   .||:||.|:||.||||||||||:
  Fly   522 AVDALKKAGNVVKLHVKRKRGTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGI 586

Human   252 GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG----LEDVMHEDAVAALKNTYDVV 312
            |||||||||.|||||:::||||..||||.||||::||.:.|    ||:|.||.|||.||:..|.|
  Fly   587 GNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKV 651

Human   313 YLKVAK----------------PSNAYLSDSYAPPDITTSYSQHLDNEISH-------------S 348
            .|.:.|                .|...||.|.:  .:.||.||...::..|             |
  Fly   652 TLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQS--QLATSQSQSQVHQQQHATPMVNSQSTEPGS 714

Human   349 SYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 413
            .|..|:...|:.|.:||..|        .|||.||||.|.|.:|..||||||||||||:||::||
  Fly   715 RYASTNVLAAVPPGTPRAVS--------TEDITREPRTITIQKGPQGLGFNIVGGEDGQGIYVSF 771

Human   414 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIH 478
            |||||||||..||::|||:||||.|:|.:|:||:||.|||.:|..||::|||:||||:||||:|.
  Fly   772 ILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQ 836

Human   479 DLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW 543
            :|::|....:.||||. ||:..||..|:|||||||..:|.|..|:.|.|:.||:|||.:|||:||
  Fly   837 ELKQQAALGAGGSGTL-LRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEW 900

Human   544 WQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYAR 608
            ||||||..|:|.:.||.:|||||.||    :::|:|  .|...||                |.|
  Fly   901 WQARRVLGDNEDEQIGIVPSKRRWER----KMRARD--RSVKFQG----------------HAA- 942

Human   609 PIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKD 665
                       ||::|     ||..:    ..|.|:.:.. .|.:.|:.||::..:|
  Fly   943 -----------ANNNL-----DKQST----LDRKKKNFTF-SRKFPFMKSRDEKNED 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLG4	XP_011522001.1	L27	<26..49	CDD:413432	11/22 (50%)
		MAGUK_N_PEST	54..137	CDD:402306	13/97 (13%)
		PDZ	138..222	CDD:395476	57/83 (69%)
		PDZ	233..317	CDD:395476	57/87 (66%)
		PDZ_assoc	318..385	CDD:402299	23/95 (24%)
		PDZ	383..467	CDD:214570	56/83 (67%)
		SH3_DLG4	503..568	CDD:212963	38/64 (59%)
		Guanylate_kin	606..784	CDD:395500	13/60 (22%)
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	12/24 (50%)
		PDZ	454..540	CDD:214570	58/85 (68%)
		PDZ_signaling	566..655	CDD:238492	58/88 (66%)
		PDZ_signaling	742..820	CDD:238492	52/77 (68%)
		SH3_DLG-like	862..922	CDD:212795	35/59 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146065
Domainoid	1	1.000	124	1.000	Domainoid score	I5518
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	892	1.000	Inparanoid score	I392
Isobase	1	0.950	-	0	Normalized mean entropy	S1843
OMA	1	1.010	-	-		QHG52541
OrthoDB	1	1.010	-	-		D349551at33208
OrthoFinder	1	1.000	-	-		FOG0000833
OrthoInspector	1	1.000	-	-		otm40275
orthoMCL	1	0.900	-	-		OOG6_101347
Panther	1	1.100	-	-	O	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.760