DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment B0252.1 and btl

DIOPT Version :9

Sequence 1:	NP_495419.2	Gene:	B0252.1 / 174133	WormBaseID:	WBGene00015087	Length:	809	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	192/841 - (22%)
Similarity:	311/841 - (36%)	Gaps:	212/841 - (25%)

- Green bases have known domain annotations that are detailed below.

Worm    44 LVTVTPETDIRQFEDLL------------NSYGRLMPFNSTQQIKY-DFYFGSNYSTIVTTNDLI 95
            |:|...|..:.:..::|            |..||      |....| |.|..|:.:|:.||.
  Fly   304 LITRMDEPQVLRLGNVLMEDGGWYICIAENQVGR------TVAASYVDLYSPSDTTTVRTTT--- 359

Worm    96 KEISEWFNDTNYYPLLYASALTPSASNKQYE---TEALVSIGKTILDNVAKDNQQVL---TVYLK 154
                   ..|...|:..||  |...::...|   .||...:|..:.....|..|..|   ||.|.
  Fly   360 -------TTTVASPIPTAS--TGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLA 415

Worm   155 KQVVLLTDYAPLNITDIFNRNQNENTQRLALSYADDLTPLEEAAEFPVFKSDDEMNLSATRNIFQ 219
            ..|     |...|||                 :..|..||..  |..|:              .|
  Fly   416 CPV-----YGKANIT-----------------WTKDKKPLNR--ELGVY--------------VQ 442

Worm   220 ENRDFEFPAIIHEDKPSSDVY---------VFMTSFNVSQLMRVVESTINGPTCQMSQTKMYSQF 275
            :|....|.....||   |.:|         .....|:|    ::.:.|.:.|...:.|.:...
  Fly   443 KNWTLRFVEATSED---SGLYNCKVCNAWGCIQFDFSV----QINDRTRSAPIIVVPQNQTVK-- 498

Worm   276 VHSQIIKNGTVWQIILP---WLGQKTHSFSSNCLKSFNHMAAEPNCTAMKAQIYANFVEHVAAAN 337
            |:..::...||:..:.|   |......:.|.:.|||..  ....|.|.....:       |....
  Fly   499 VNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVE--IQNLNFTVTNDSV-------VLTLR 554

Worm   338 NQTFCYLFVGNAECATTTNLTTNIKDSTHIRLVMDEDLNDVYE-------DFTLPLVNLGFLDKT 395
            |.||..  .|...|..::.|..: ..|.::|:|......::|.       .|||..:.:
  Fly   555 NVTFDQ--EGWYTCLASSGLGRS-NSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITI------ 610

Worm   396 VDNQVIHNDMFYLQNYSTSCTDEIPMVPLLSA------RPWHRPKYLSIALDDMLTIFICATISV 454
                                   :.:..|.||      |...|.|.|.:.::         |:..
  Fly   611 -----------------------VALFLLGSAFITFMLRRLRREKLLKLRIE---------TVHQ 643

Worm   455 TTFGILIYRHVSRKHRQQVELLSELMLQPRIYKAPKECAKVA----------------RLP---- 499
            .|..::||    |...::....|...||..:.:..|:...|:                ..|
  Fly   644 WTKKVIIY----RPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSN 704

Worm   500 WEIKSENVHIDKEFLLGEGTISNVYLGKLKG--KSPIMQWIDRVEMKQYQDCAVAVR-VPSHFDE 561
            |||..:.:.:..  :||||....|.:.:.:|  :||           |..:..|||: |.....:
  Fly   705 WEIPRQQLSLGS--ILGEGAFGRVVMAEAEGLPRSP-----------QLAETIVAVKMVKEEHTD 756

Worm   562 PEEDQLQREIASMRQLRHHDHIALLLGWTNKNDLVCSLLELT-HMNLIKYLSQIRETAEQ--DNS 623
            .:...|.||:..|:.:..|.:|..|||..::...:..::|.. |.||..:|.|.|..|.|  .:|
  Fly   757 TDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDS 821

Worm   624 SGF---TPM---SRIPFQVLYKIIYEICDGIEYIHSRNLVHRDLTARNVLLTTGLRAKISGFGFC 682
            .|:   .|:   ..:..:.|.|..::|..|:||:.||..:||||.|||||::.|...||:.||..
  Fly   822 DGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLA 886

Worm   683 SEPDDPKFAANSLALRYLPVRWLAPECF-IGKFSVKSDSWSFGVLMYEMFSLGEQPYEDLIRPEE 746
            .:..|.::...:...| ||::|:|||.. ..|:..:||.||:|||::|:.:.|:|||..::..||
  Fly   887 RDIQDTEYYRKNTNGR-LPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEE 950

Worm   747 IIESIRKGRVPAHPKYCSKQTYKIMQSCYQSFMSRRPNFTQLKNAFH--VQSTNYYNNPAF 805
            :...:..|:....|..||...|.:|:.|:......||.|.:|..:|.  :|..:...|.|:
  Fly   951 LYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAY 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B0252.1	NP_495419.2	PKc_like	515..792	CDD:389743	90/289 (31%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	5/31 (16%)
		Ig	258..340	CDD:143165	8/41 (20%)
		I-set	394..479	CDD:254352	25/129 (19%)
		IGc2	408..469	CDD:197706	20/101 (20%)
		IG_like	492..583	CDD:214653	20/104 (19%)
		Ig	507..583	CDD:299845	18/87 (21%)
		PKc_like	700..1000	CDD:304357	95/313 (30%)
		TyrKc	712..996	CDD:197581	90/297 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810