DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DLG3 and SPBC1198.05

DIOPT Version :9

Sequence 1:	XP_006724688.1	Gene:	DLG3 / 1741	HGNCID:	2902	Length:	849	Species:	Homo sapiens
Sequence 2:	NP_595074.1	Gene:	SPBC1198.05 / 2539674	PomBaseID:	SPBC1198.05	Length:	202	Species:	Schizosaccharomyces pombe

Alignment Length:	182	Identity:	56/182 - (30%)
Similarity:	95/182 - (52%)	Gaps:	11/182 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   660 RPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDN 721
            :||::.||.   |..:...|:.:...|.|..|.||||..|..|.||.|||| |::|:.:|.:.:.
pombe    19 KPVVVFGPSGVGKSTLLKRLLKDHGDKLGFSVSHTTRTPRAGEKDGIDYHF-VTKEEFQKLVAEE 82

Human   722 KFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEM 786
            ||:|...|:.|:|||||.:::.:....|..|||:....:.:::.:.:....:|:.|.|||.|...
pombe    83 KFVEWAVFSGNMYGTSIMAIQELEAVNKKAILDIDLQGVLQVKASPIDAQYVFLAPPSIEQLEVR 147

Human   787 NRRQTYEQANKIYDKAMKLEQEFGEY------FTAIVQGDSLEEIYNKIKQI 832
            .|.:..|..:.|..:..:...|. ||      |.|::..|.:|:.|.:::.|
pombe   148 LRGRGTENESAILQRLERARAEI-EYSEKPGNFDALIVNDDVEKAYKQLEAI 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLG3	XP_006724688.1	MAGUK_N_PEST	52..130	CDD:402306
		PDZ_signaling	131..208	CDD:238492
		PDZ_signaling	224..310	CDD:238492
		PDZ_assoc	311..385	CDD:402299
		PDZ_signaling	384..462	CDD:238492
		SH3_DLG3	502..568	CDD:212962
		Guanylate_kin	658..836	CDD:395500	56/182 (31%)
SPBC1198.05	NP_595074.1	Gmk	17..201	CDD:223272	56/182 (31%)
SPBC1198.05	NP_595074.1	guanyl_kin	19..201	CDD:213788	56/182 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810